Evaluation of serum and aqueous humor klotho levels in pseudoexfoliation syndrome, pseudoexfoliation and primary open-angle glaucoma

Tokuç, Ecem Önder; Yüksel, Nurşen; Kır, Hale Maral; Acar, Esra

doi:10.1007/s10792-021-01790-5

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Citicoline has been used in the treatment of Primary Open Angle Glaucoma (POAG) since the late 1980s, in order to enhance both retinal and visual functions [ 11 , 12 , 13 , 14 , 15 ]. In this regard, citicoline in oral solution was registered in four European countries as a “Food for Special Medical Purposes” with the therapeutic indication “for glaucomatous patients, pharmacologically-stabilized and with a progressive loss of the visual field”.…”

Section: Introductionmentioning

confidence: 99%

“…Given the complex nature of POAG, it is also necessary to consider IOP-independent therapeutic targets in order to prevent RGC death, including the trabecular meshwork (TM), mitochondria and cell membranes [ 15 ]. As known, the TM represents the first barrier to the outflow of aqueous humor (AH) through the conventional pathway of the human eye.…”

Section: Introductionmentioning

confidence: 99%

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Citicoline Eye Drops Protect Trabecular Meshwork Cells from Oxidative Stress Injury in a 3D In Vitro Glaucoma Model

Vernazza

Passalacqua

Tirendi

et al. 2022

IJMS

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Intraocular pressure (IOP) is considered an important modifiable risk factor for glaucoma, which is known as the second leading cause of blindness worldwide. However, lowering the IOP is not always sufficient to preserve vision due to other non-IOP-dependent mechanisms being involved. To improve outcomes, adjunctive therapies with IOP-independent targets are required. To date, no studies have shown the effect of citicoline on the trabecular meshwork (TM), even though it is known to possess neuroprotective/enhancement properties and multifactorial mechanisms of action. Given that reactive oxygen species seem to be involved in glaucomatous cascade, in this present study, an advanced millifluidic in vitro model was used to evaluate if citicoline could exert a valid TM protection against oxidative stress. To this end, the cellular behavior, in terms of viability, apoptosis, mitochondrial state, senescence and pro-inflammatory cytokines, on 3D human TM cells, treated either with H2O2 alone or cotreated with citicoline, was analyzed. Our preliminary in vitro results suggest a counteracting effect of citicoline eye drops against oxidative stress on TM cells, though further studies are necessary to explore citicoline’s potential as a TM-target therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Citicoline Eye Drops Protect Trabecular Meshwork Cells from Oxidative Stress Injury in a 3D In Vitro Glaucoma Model

Vernazza

Passalacqua

Tirendi

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

Klotho: A new therapeutic target in diabetic retinopathy?

Puddu¹,

Maggi²

2023

World J Diabetes

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The prevalence of diabetes mellitus is increasing in resource limited settings. Simultaneously, there has been an increase in the number of novel therapies for the management of diabetes mellitus. However, use of novel antidiabetic therapies is limited because of major market access challenges in resource limited settings. Niching products to those patients with the highest absolute risk for major adverse cardiovascular outcomes, and thus most likely to benefit from the therapy, are less likely to have negative budget impact for funders. To improve access, and reduce morbidity and mortality, requires alignment amongst key stakeholders including patient advocacy groups, health care professional councils, national departments of health, the pharmaceutical industry, treasury and finance departments.

show abstract

Evaluation of serum and aqueous humor klotho levels in pseudoexfoliation syndrome, pseudoexfoliation and primary open-angle glaucoma

Cited by 2 publications

References 34 publications

Citicoline Eye Drops Protect Trabecular Meshwork Cells from Oxidative Stress Injury in a 3D In Vitro Glaucoma Model

Citicoline Eye Drops Protect Trabecular Meshwork Cells from Oxidative Stress Injury in a 3D In Vitro Glaucoma Model

Klotho: A new therapeutic target in diabetic retinopathy?

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