Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis, severe sepsis, and septic shock

Heper, Yasemin; Akalin, Enver; Mıstık, Reşit; Akgöz, Semra; Töre, Okan; Göral, Güher; Oral, Barbaros; Budak, Ferah; Helvacı, Safiye

doi:10.1007/s10096-006-0168-1

Cited by 101 publications

(105 citation statements)

References 30 publications

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“…Among the potentially useful sepsis markers, tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 8 (IL-8), and interleukin-10 (IL-10) have been proposed to be the most promising candidates [1,2,9].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of C-reactive protein, procalcitonin, tumor necrosis factor alpha, interleukin-6, and interleukin-8 as diagnostic parameters in sepsis-related fatalities

et al. 2011

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The aims of this study were to investigate the usefulness of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, interleukin-6, and interleukin-8 as postmortem markers of sepsis and to compare C-reactive protein and procalcitonin values in serum, vitreous humor, and cerebrospinal fluid in a series of sepsis cases and control subjects, in order to determine whether these measurements may be employed for the postmortem diagnosis of sepsis. Two study groups were formed, a sepsis group (eight subjects coming from the intensive care unit of two university hospitals, with a clinical diagnosis of sepsis in vivo) and control group (ten autopsy cases admitted to two university medicolegal centers, deceased from natural and unnatural causes, without elements to presume an underlying sepsis as the cause of death). Serum C-reactive protein and procalcitonin concentrations were significantly different between sepsis cases and control cases, whereas serum tumor necrosis factor alpha, interleukin-6, and interleukin-8 values were not significantly different between the two groups, suggesting that measurement of interleukin-6, interleukin-8, and tumor necrosis factor alpha is non-optimal for postmortem discrimination of cases with sepsis. In the sepsis group, vitreous procalcitonin was detectable in seven out of eight cases. In the control group, vitreous procalcitonin was clearly detectable only in one case, which also showed an increase of all markers in serum and for which the cause of death was myocardial infarction associated with multiorganic failure. According to the results of this study, the determination of vitreous procalcitonin may be an alternative to the serum procalcitonin for the postmortem diagnosis of sepsis.

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Section: Introductionmentioning

confidence: 99%

“…They found that procalcitonin and IL-10 were more useful in discriminating between sepsis and severe sepsis, whereas TNF-α and IL-10 were more useful in predicting which cases were likely to have a fatal outcome [9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of C-reactive protein, procalcitonin, tumor necrosis factor alpha, interleukin-6, and interleukin-8 as diagnostic parameters in sepsis-related fatalities

et al. 2011

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“…Another study by Heper et al (2006) expressed the sensitivity and specificity for procalcitonin by 88 and 70% respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, several biomarkers are being introduced. For example different types of cytokine, such as TNF-a, IL10 and CRP and also procalcitonin which are more suggested by the useful recent studies and have been able to become a head of other markers (Heper et al, 2006;Charalampos and Vincent, 2010).…”

Section: Ajidmentioning

confidence: 99%

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Procalcitonin as a Marker for Early Diagnosis of Sepsis

Raoofi¹,

Salmani²,

Moradi³

et al. 2014

American Journal of Infectious Diseases

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Sepsis is a critical condition often caused by bacterial infection and associated with death and mortality. The prognosis of this disease depends on early diagnosis and proper treatment. Definite diagnosis of sepsis is positive blood culture and this test needs a long time to perform, so other biochemical parameters such as procalcitonin serum level has been introduced. To determine sensitivity, specificity, positive and negative predictive value of procalcitonin serum level at first time and 72 h after admission and to compare it with blood culture test for diagnosis of sepsis. Blood sample for blood culture, prepheral blood smear at first time and procalcitonin serum level measuring by semi quantitative method at first and 72 h after admission were sampled. Nine patients had positive blood cultures. Peripheral blood smear was positive in 38 patients, (29 patients: gram stain positive, 6 patients: gram stain negative and 3 patients: both gram positive and gram negative). At first time 76.8% had positive procalcitonin (>0.5 ng mL −1 ) and after 72 h 65% of patients had positive procalcitonin. Sensitivity, specificity, positive and negative predictive value of procalcitonin at the first time were 100, 16,16 and 100% and for procalcitonin after 72 h respectively were 75, 35, 15 and 90%. This study showed that sensitivity of procalcitonin serum level can be used for diagnosis of sepsis. Procalcitonin increased as severity of sepsis and this study suggests high serum level of procalcitonin after 72 h might indicate poor outcome.

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Serum amyloid A does not predict non‐survival in hospitalised adult horses with acute colitis

et al. 2023

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Background Predicting non‐survival in horses with acute colitis improves early decision making. Therefore, this study aimed to determine the prognostic value of serum amyloid A (SAA) and other clinicopathological and clinical variables in adult horses with acute colitis. Methods Clinical variables, SAA and other blood biomarkers, including plasma L‐lactate (lactate), were assessed in 176 horses with acute colitis. A multivariate model for the prediction of non‐survival was constructed. Icelandic horses were analysed separately. Results Admission SAA was similar in survivors (median 548 mg/L; range 0–5453 mg/L) and non‐survivors (396 mg/L; 0–5294) (p = 0.43). A model for non‐survival included year of admission, lactate, heart rate, age and colic duration of more than 24 hours. Icelandic horses had a relative risk of 2.9 (95% confidence interval = 2.2–3.8) for acute colitis compared to other breeds. Lactate in Icelandic horses was higher than that in other breeds in both survivors (4.0 mmol/L, range 1.0–12.7 vs. 2.0, 0.7–12.5) and non‐survivors (10.0, 1.5–26 vs. 5.4, 0.8–22) (p < 0.001). Limitations The prognostic value of repeated measurements of SAA could not be assessed in this study, as 71% of the non‐surviving horses died within a day of admission. Conclusion Admission SAA did not predict non‐survival. Breed needs consideration when lactate is evaluated as a predictor for non‐survival in horses with colitis.

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Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis, severe sepsis, and septic shock

Cited by 101 publications

References 30 publications

Evaluation of C-reactive protein, procalcitonin, tumor necrosis factor alpha, interleukin-6, and interleukin-8 as diagnostic parameters in sepsis-related fatalities

Evaluation of C-reactive protein, procalcitonin, tumor necrosis factor alpha, interleukin-6, and interleukin-8 as diagnostic parameters in sepsis-related fatalities

Procalcitonin as a Marker for Early Diagnosis of Sepsis

Serum amyloid A does not predict non‐survival in hospitalised adult horses with acute colitis

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