Evaluation of serum feline trypsin-like immunoreactivity for the diagnosis of pancreatitis in cats

Swift, Nigel C.; Marks, Stanley L.; Maclachlan, Nigel J; Norris, Carol R.

doi:10.2460/javma.2000.217.37

Cited by 102 publications

(150 citation statements)

References 16 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…Serum tTLI values show a poor correlation with the severity of AP. Furthermore, the high rate of false negative results (low sensitivity) may be due to fast removal of trypsinogen and trypsin from the bloodstream due to the small size of the molecule and also to the binding and removal by proteinase inhibitors in the serum (28). Moreover, trypsin synthesis from damaged acinar cells may be decreased, and overall serum TLI concentration may be normal, despite the ongoing pancreatic inflammation (3).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Investigation of Experimental Acute Pancreatitis in the Cat

Zavros¹,

Rallis²,

Koutinas³

et al. 2008

Eur J Inflamm

View full text Add to dashboard Cite

The main objective of this study is the serial evaluation of clinical and laboratory changes in cats with experimentally-induced acute pancreatitis (AP). A total of 16 clinically healthy young adult DSH cats were included in the study. Acute pancreatitis was induced in 10 (AP group) by infusing oleic acid into the pancreatic duct, while the other 6 cats served as sham-operated controls (C group). Depression or lethargy, anorexia, abdominal pain, and a palpable mass in the anterior abdomen were the main clinical findings in cats of the AP group. Laboratory data revealed non-regenerative anaemia, mild hypoalbuminaemia, transient hyperglycaemia, and hypertriglyceridaemia. Serum lipase activity, feline trypsin-like immunoreactivity (ITLI) concentration, and feline pancreatic lipase immunoreactivity (fPLI) concentration increased significantly within the first 24 hours after the infusion of oleic acid, with time-dependent positive correlation. In both group of cats urine amylase-creatinine ratio and amylase-creatinine clearance ratio were increased. In cats of the AP group, abdominal ultrasonography revealed a hypoechogenic and enlarged pancreas, along with peripancreatic fluid accumulation. Peritoneal effusion was consistent with a sterile exudate, with higher lipase but lower amylase activities when compared to their serum counterparts in all AP group cats. The induction of AP was confirmed by pancreatic histopathology. AP is characterized by vague symptomatology. Increases in serum ITLI and fPLI concentrations occur early in cats with pancreatitis. In general the two analytes run a parallel course, but fPLI may be increased longer than ITLI. The measurement of lipase activity in the peritoneal fluid could be considered diagnostic.Despite the fact that acute pancreatitis (AP) in the cat is difficult to diagnose, it is widely accepted that it is a rather commonly occurring though underdiagnosed disease (1-2). The aetiopathogenesis of feline AP is poorly understood, although it has been attributed to several causative and risk

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Investigation of Experimental Acute Pancreatitis in the Cat

Zavros¹,

Rallis²,

Koutinas³

et al. 2008

Eur J Inflamm

View full text Add to dashboard Cite

show abstract

“…Several articles that discuss the clinical aspects of pancreatitis occasionally provide minimal information on the histopathology of pancreatitis in the cat. 19,26,30,39 The histopathology of experimentally induced chronic pancreatitis in the cat, either by intraductal or intraparenchymal injection of ethanol or by ligation of the pancreatic duct, has been described. 43,44 Total obstruction, caused by intraductal damage by ethanol or ligation of the pancreatic duct, resulted initially in an acute necrotizing pancreatitis that progressed to a pronounced and progressive atrophy of both endocrine and exocrine tissues associated with prominent ductular dilation.…”

mentioning

confidence: 99%

Prevalence and Histopathologic Characteristics of Pancreatitis in Cats

et al. 2007

View full text Add to dashboard Cite

Abstract. Despite the high prevalence of feline pancreatic disease, no detailed description on the histopathologic nature of this disease is currently available in the literature. In this study we characterize the distribution and histopathologic changes commonly found in feline pancreases, correlate the lesions with age and gastrointestinal GI and extra-gastrointestinal disease, and compare the pancreatic lesions in cats with those in humans. The entire pancreas was removed and examined from 115 cats presented for necropsy irrespective of the cause of death. Histologic sections from left limb, right limb, and body were scored for lesions of acute (AP) and chronic pancreatitis (CP) with a scoring system based on similar systems used in human and veterinary literature. The lesions of CP in cats resemble CP in humans, with fibrosis being more prominent than inflammatory changes. Cystic degeneration gradually increased as other lesions of CP were more prominent. A distinct nodular change of zymogen depletion and acinar cell dysplasia not associated with pancreatitis was prominent in 15.6% of the pancreases. Histologically, AP consisted of neutrophilic inflammation associated with interstitial edema and necrosis of mesenteric fat.An overall prevalence of 67%, and 45% in clinically normal animals, was identified. CP was found in 69 (60.0%) pancreases, and 58 (50.4%) had CP only, with a significant correlation between age and occurrence of CP. There was a statistically significant higher prevalence of CP in the left limb in animals with gastrointestinal disease. AP was present in 18 animals (15.7%) of which 7 animals had AP only (6.1%).

show abstract

“…Γάτες κάθε ηλικίας, φυλής και γένους μπορεί να εμ φανίσουν παγκρεατίτιδα (Macy 1989, Hill and Van Winkle 1993, Akol et al 1993, Swift et al 2000, Gerhardt et al 2001, Kimmel et al 2001, Ferreri et al 2003, Forman et al 2004. Οι περισσότερες μελέτες δείχνουν ότι στην πλειοψηφία των περιπτώσεων προ σβάλλονται γάτες της φυλής κοινή ευρωπαϊκή, ενώ σε μια μελέτη (Hill and Van Winkle 1993) η φυλή Siamese εμφάνιζε προδιάθεση.…”

Section: ιστορικο και κλινικη εικοναunclassified

“…Η τελευταία, σε ορισμένες περιπτώσεις, είναι δυνατό να οφείλεται σε συνυπάρχοντα σακχαρώδη διαβήτη (Hess et al 1999, Ferreri et al 2003. Σε αντί θεση με το σκΰλο, μια από τις πιο συχνές και κλινικά σημαντικές ηλεκτρολυτικές διαταραχές σε γάτες με παγκρεατίτιδα είναι η υπασβεστιαιμια (3%-5% των σκύλων, 45%-65% των γατών) (Hill and Van Winkle 1993, Hess et al 1998, Hess et al 1999, Swift et al 2000, Kimmel et al 2001, Ferreri et al 2003. Η πα ρουσία υπασβεστιαιμιας (ολικό ή/και ιονισμένο ασβέ στιο) σε γάτες με συμβατή κλινική εικόνα θα πρέπει πάντα να εγείρει την υποψία παγκρεατίτιδας.…”

Section: εργαστηριακες εξετασεις αιματολογική εξέταση απλή βιοχημικήunclassified

Current concepts in the diagnosis of pancreatitis in dags and cats

Xenoulis

Steiner

2017

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

show abstract

Evaluation of serum feline trypsin-like immunoreactivity for the diagnosis of pancreatitis in cats

Abstract: In cats with clinical signs of pancreatitis, serum fTLI concentration is poorly associated with histopathologic diagnosis.

Cited by 102 publications

References 16 publications

Clinical and Laboratory Investigation of Experimental Acute Pancreatitis in the Cat

Clinical and Laboratory Investigation of Experimental Acute Pancreatitis in the Cat

Prevalence and Histopathologic Characteristics of Pancreatitis in Cats

Current concepts in the diagnosis of pancreatitis in dags and cats

Contact Info

Product

Resources

About