Evaluation of serum ferritin in in type II diabetes mellitus: a hospital based observational study from Dibrugarh, Assam, India

Borah, Meghna; Goswami, Rohini Kanta

doi:10.18203/2320-6012.ijrms20163791

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…A significant positive correlation is seen between cases with high FBS, high PPBS, increased HbA1c% and serum ferritin cases of the study. The prevalence of hyperferritenemia is 74.2% in the diabetic cases in the present study which is similar to the findings in the study of Meghna Borah et al 16 To conclude this study clearly explains that there is a significant increase in the serum ferritin in cases of diabetes mellitus compared to normal controls and hyperferritenemia may be one of the causes for decreased insulin production and development of insulin resistance in diabetic individuals. It was also observed that poorly controlled diabetic cases with elevated HbA1c% had significant hyper ferritenemia.…”

Section: Discussionsupporting

confidence: 91%

A study on estimation of serum ferritin in type 2 diabetes mellitus cases on oral hypoglycemic agents

2020

IJCBR

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Introduction: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and associated micro and macro vascular complications on long duration. Insulin resistance is associated with onset of type 2 DM and various studies point its connection to iron overload in the body. Hyperinsulinemia due to resistance to insulin may be responsible for increasing serum Ferritin. Objectives: The present study was carried out to determine the relationship between serum Ferritin and type 2 diabetes mellitus and to establish correlation between serum Ferritin and fasting blood glucose as well as with HbA1c. Materials and Methods: An observational study for one year at a tertiary care hospital was carried on 50 diabetic male cases and 50 age matched controls. BMI, serum ferritin, HbA1c, FBS and PPBS were estimated on all the cases and controls as per standard guidelines and compared between cases and controls. P value less than 0.05 was considered statistically significant. Results: In the present study, 41-50 years was the common age group, and BMI (kg/m 2), Fasting blood sugar, Post prandial blood sugar parameters were statistically significant between cases and controls. The mean HbA1c% in cases was 9.48 ± 2.65 and greater than controls and significant correlation with serum ferritin levels which was 359.11 ± 87.18 was observed. Greater levels of Serum ferritin was observed in cases with elevated levels of HbA1c%. A strong positive correlation was found between serum ferritin and HbA1c, FBS and PPBS levels in the study. Discussion: This study clearly explains that there is a significant increase in the serum ferritin in cases of diabetes mellitus compared to normal controls and hyperferritenemia may be one of the causes for decreased insulin production and development of insulin resistance in diabetic individuals. Study of iron and related parameters may be a useful offshoot of the conventional studies on diabetes and its complications. Hence monitoring the prevalence of serum ferritin is beneficial in long rum among the diabetics.

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Section: Discussionsupporting

confidence: 91%

A study on estimation of serum ferritin in type 2 diabetes mellitus cases on oral hypoglycemic agents

2020

IJCBR

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“…However, it is pertinent to note that the plasma levels of the antioxidants (enzymatic and nonenzymatic) studied (superoxide dismutase, reduced glutathione and catalase) did not show any significant differences between DM patients and controls. While our data on superoxide dismutase is at variance with that reported by Mizobuchi et al (19), the plasma levels of ferritin observed is in tandem with other reported studies elsewhere (20,21). Plasma ferritin levels, related to body iron stores is influenced by several diseases and these have been increasingly connected to insulin resistance in Type 2 DM.…”

Section: Discussionsupporting

confidence: 83%

Plasma Ferritin Levels, Oxidative Stress and Nephropathy in Diabetes

Azenabor

Kolawole

Williams

et al. 2018

JBMS

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Background: Elevated plasma levels of ferritin and oxidative stress have been associated with diabetic nephropathy; the onset of which is insidious. The early stages of glomerular hyper filtration often go unnoticed in the majority of subjects. This limit the precision of creatinine based glomerular filtration rate estimates. Objective: We sought to document the role of plasma ferritin and oxidative stress markers in the early detection of nephropathy in diabetes mellitus (DM). Subjects and Methods: This was a cross sectional analytical study conducted on 360 participants, comprising of 220 with DM and 140 age matched apparently healthy control individuals. Fasting blood samples were collected for the estimations of glucose, plasma ferritin, urea, creatinine and oxidative stress markers (malondialdehyde, superoxide dismutase, reduced glutathione and catalase). Results: The mean ferritin levels in DM (83.77 ± 4.18 ng/ml) was significantly higher than the controls (55.60 ± 10.41ng/ml) (p = 0.004) . A significant correlation of ferritin and malondiadehyde (r = 0.422, p = 0.050) was observed in DM. Inverse associations of creatinine and superoxide dismutase (r = -0.298, p = 0.011), as well creatinine and catalase (r = -0.270, p = 0.022) were observed in DM. Possible predictors of nephropathy include ferritin, superoxide dismutase, catalase and reduced glutathione. Conclusion: Elevated plasma ferritin levels in addition to some antioxidant enzymes, notably superoxide dismutase and catalase, contribute to the pathogenesis of nephropathy in DM.

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“…People with high ferritin levels were found to be at a higher risk of DM. In addition, a positive correlation was demonstrated in previous studies between serum ferritin and glycemic control in T2DM patients measured by FBG, fructosamine, or HbA1c [16][17][18][19]. Our study showed that serum ferritin was not associated with glycemic control in patients with T2DM.…”

Section: Discussionsupporting

confidence: 65%

The association between serum ferritin and bilirubin with glycemic control among patients with type 2 diabetes mellitus

Al Argan,

Alkhafaji,

Al Elq

et al. 2023

JMedLife

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Previous evidence has shown an association between serum ferritin and bilirubin levels in the development of type 2 diabetes mellitus (T2DM) and glycemic control. However, the evidence is scarce in Saudi Arabia. In this study, we aimed to evaluate the association between serum ferritin and bilirubin levels with glycemic control in patients with T2DM. This was a cross-sectional study that involved 153 patients with T2DM recruited from outpatient diabetes clinics. Participants were categorized into two groups: well-controlled and uncontrolled T2DM, based on their glycemic status. We focused on comparing the iron profile and bilirubin levels between these two groups and examining the influence of antidiabetic medications on these parameters. A total of 153 patients with T2DM were included (58.2% women and 41.8% men). In both univariate and multivariate analyses, ferritin levels did not have a statistically significant association with glycemic control. However, patients with well-controlled T2DM had a significantly higher median level of total bilirubin and direct bilirubin than those with uncontrolled T2DM. Only direct bilirubin showed a statistically significant association with FBG less than 130 mg/dl and HbA1c level less than 7.0%. Ferritin level was not associated with glycemic control in patients with T2DM. On the other hand, direct bilirubin level was an independent predictor of better glycemic control. Monitoring direct bilirubin levels could aid in predicting glycemic control in T2DM and could be a potential target for developing antidiabetic medications.

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Evaluation of serum ferritin in in type II diabetes mellitus: a hospital based observational study from Dibrugarh, Assam, India

Cited by 9 publications

References 17 publications

A study on estimation of serum ferritin in type 2 diabetes mellitus cases on oral hypoglycemic agents

A study on estimation of serum ferritin in type 2 diabetes mellitus cases on oral hypoglycemic agents

Plasma Ferritin Levels, Oxidative Stress and Nephropathy in Diabetes

The association between serum ferritin and bilirubin with glycemic control among patients with type 2 diabetes mellitus

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