Evaluation of Serum <i>Aspergillus</i>‐Specific Immunoglobulin A by Indirect ELISA for Diagnosis of Feline Upper Respiratory Tract Aspergillosis

Taylor, Amanda R.; Peters, Iain R.; Dhand, Navneet K.; Whitney, Joanna; Johnson, Lynelle R.; Beatty, Julia A.; Barrs, Vanessa R.

doi:10.1111/jvim.14567

Cited by 8 publications

(2 citation statements)

References 34 publications

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“…No differences between the tested species were found. Assessing IgA titers did not improve the results obtained by IgG alone ( Taylor et al, 2016 ).…”

Section: Veterinary Infections Caused By Aspergillus mentioning

confidence: 99%

Diagnostic Aspects of Veterinary and Human Aspergillosis

Elad

Segal

2018

Front. Microbiol.

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The genus Aspergillus is composed of more than 300 species, a fraction of which are involved in animal or human infections mostly following environmental exposure. Various risk factors (i.e., immunosuppression, tuberculosis) have been recognized for human whereas for veterinary infections, unhygienic management, trauma, anatomical conformation of the skull, or suspected immunological deficiencies have been suggested. In animals, aspergillosis is mostly sporadic but in some circumstance such as infections on poultry farms may involve the whole flock. Since the high prevalence of immunosuppression in human patients has not been mirrored in veterinary medicine, and although to the best of our knowledge, no comprehensive data on the prevalence of aspergillosis in animals has been published, their epidemiology has not changed during the last decades. The impact of these infections may be economic or if they are incurable, sentimental. The objective of the first part is to describe the diagnosis of the main clinical entities caused by Aspergillus spp. in animals. It includes disseminated canine aspergillosis, canine and feline sino-nasal and sino-orbital aspergillosis, guttural pouch mycosis in horses, mycotic abortion in cattle, mycotic keratitis in horses, and avian aspergillosis. When pathogenesis and clinical aspects are relevant for diagnosis—they will be addressed as well. The second part deals with human aspergillosis, which is a multifaceted disease, manifested in a spectrum of clinical entities affecting one or more organs. Diagnosis is based on the clinical manifestation, supported and confirmed by laboratory means, involving the classical approach of demonstrating the etiological agent in the clinical specimens and in culture. Noncultural methods, such as antigen detection and/or molecular assays to detect fungal nucleic acids or protein profiles, are used as well. The isolation and identification of the fungus allows the determination of its susceptibility to antifungal drugs. Thus, antifungal susceptibility testing maybe considered as part of the diagnostic process, which is of relevance for management of the infection. In this review article, the part dealing with diagnostic aspects of aspergillosis in humans concentrates on susceptibility testing of Aspergillus spp. to antifungal drugs and drug combinations. The technologies and methods of susceptibility testing are described and evaluated.

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“…No differences between the tested species were found. Assessing IgA titers did not improve the results obtained by IgG alone ( Taylor et al, 2016 ).…”

Section: Veterinary Infections Caused By Aspergillus mentioning

confidence: 99%

Diagnostic Aspects of Veterinary and Human Aspergillosis

Elad

Segal

2018

Front. Microbiol.

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“…DNA extracted from the cultured fungus was subjected to PCR and Sanger sequencing of the partial betatubulin, calmodulin, RPB2 and actin genes, and definitively identified as A felis as previously described (GenBank accession numbers 95876‐95879) 8 . Serum collected on day 357 was positive for Aspergillus IgG on ELISA, titer of 288 EU/mL (positive >5 EU/mL) 9 …”

Section: Casementioning

confidence: 99%

Disseminated invasive aspergillosis caused by Aspergillus felis in a cat

Cormack

Donahoe

Talbot

et al. 2021

Veterinary Internal Medicne

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A 2‐year‐old male desexed Ragdoll cat with a 1‐year history of sneezing and nasal discharge presented with a large subcutaneous cervical mass, identified as the right medial retropharyngeal lymph node on computed tomography (CT). A right orbital mass, destructive sino‐nasal cavity disease and multiple pulmonary nodules were also identified. Aspergillus felis was cultured from the lymph node. After treatment with posaconazole and liposomal amphotericin B the lymph node enlargement and orbital mass resolved but left frontal sinus involvement and pulmonary lesions persisted despite additional caspofungin therapy. The cat was euthanized 14 months after diagnosis with dysphagia and chronic progressive exophthalmos. A meningeal granuloma with intravascular fungal hyphae was identified at post‐mortem and A felis was cultured from the left frontal sinus and a right retrobulbar fungal granuloma. This case demonstrates that disseminated disease is a possible sequel to invasive fungal rhinosinusitis caused by A felis in cats.

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Feline Aspergillosis

Barrs¹

2018

Emerging and Epizootic Fungal Infections in Animals

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Evaluation of Serum Aspergillus‐Specific Immunoglobulin A by Indirect ELISA for Diagnosis of Feline Upper Respiratory Tract Aspergillosis

Cited by 8 publications

References 34 publications

Diagnostic Aspects of Veterinary and Human Aspergillosis

Diagnostic Aspects of Veterinary and Human Aspergillosis

Disseminated invasive aspergillosis caused by Aspergillus felis in a cat

Feline Aspergillosis

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