Evaluation of serum irisin levels in patients with endometrial hyperplasia: A controlled cross-sectional study

Abstract

Aim: Irisin, which is proteolytically splited form of fibronectin type III domain containing 5 (FNDC5), is a protein with 112 amino acid. Irisin is an exercise-induced hormone excreted primarily by cardiac muscle and skeletal cells which can be described as an exercise hormone and a new potential target for the treatment of metabolic diseases and obesity. Our goal was to evaluate the serum irisin levels in patients with endometrial hyperplasia (EH). Methods: An observational study is planned. The study population consisted of two groups: 1) the EH group (study group), consisting of participants who had been histopathologically diagnosed with simple EH without atypia and 2) the control group, consisting of healthy participants admitted to the clinic for an annual examination without any complaints or symptoms. Primary outcome of the study was evaluation irisin status. Serum irisin levels were determined by an enzyme-linked immunosorbent assay (ELISA) method. Results: After sample size analysis, 52 participants enrolled into the study as study group (EH group) (n=26) and control group (n=26). The mean age was 39.5±3.8 years in the EH group and 40.7±2.4 years in the control group (p=0.258). Mean BMI was 28.8±2.1 kg/m 2 in the EH group and 28.5±1.2 kg/m 2 in the control group (p=0.666). Gravidity, parity, systolic blood pleasure, diastolic blood pleasure, fasting glucose levels, smoking status, alcohol use were similar for both groups (p=0.499, p=0.278, p=0.248, p=0.424, p=0.646, p=0.486 and p=0.153, respectively). In control group regular exercise rates was significantly higher than EH group (26.9%, 3.84%, respectively p<0.001). The mean serum irisin level was 1.9±0.7 μg/ml in the EH group and 3.5±2.0 μg/ml in the control group. Serum irisin levels were found to be significantly lower in the EH group compared to the control group (p<0.001). Conclusion: The data from the current study indicate that serum irisin levels were significantly decreased in patients with endometrial hyperplasia. Serum irisin levels may open up new horizons for therapeutic targets for the treatment of patients with EH.

Retrospective examination of endometrial sampling results in women with abnormal uterine bleeding

“…One-third of outpatient visits to the gynecology and obstetrics outpatient clinic and more than 70% of the patients are AUB [8]. It is seen that OCD increases with age and is effective in the transformation of age into a risky condition, especially endometrial cancer [3,6,8,12]. In the study by Şahin et al, in order to compare the endometrial thickness and histopathological results measured by transvaginal ultrasonography in premenopausal patients with abnormal uterine bleeding, it was observed that the mean age of women was 40 years and above, and they were in the premenopausal period [6].…”

“…It is seen that OCD increases with age and is effective in the transformation of age into a risky condition, especially endometrial cancer [3,6,8,12]. In the study by Şahin et al, in order to compare the endometrial thickness and histopathological results measured by transvaginal ultrasonography in premenopausal patients with abnormal uterine bleeding, it was observed that the mean age of women was 40 years and above, and they were in the premenopausal period [6]. Aker et al examined the endometrial results in women with abnormal uterine bleeding, and in their study involving 765 cases, it was observed that the mean age of women was 43.14±7.92 in the premenopausal group and 60.7±7.88 in the postmenopausal group [3].…”

“…Careful evaluation of AUBs is of great importance for early diagnosis and treatment of endometrial cancer. Especially in the pre and post-menopausal period, women who apply with the complaint of AUB should be carefully evaluated [6].…”

Cervical Mucus SLPI is a Predictive Biomarker for Timing of Delivery in Nulliparous Term Pregnancies with Unfavorable Cervix

“…The cervical mucus was sampled as previously described [4]. The samples were obtained with the women in the lithotomy position prior other vaginal maneuvers.…”

“…Secretory leukocyte protease inhibitor (SLPI) is a low molecular-weight secretory protein found in the alveolar face of the lung, intestinal mucosa, and mucosal surface of the reproductive system [4]. The antimicrobial, anti-inflammatory, and antiprotease functions of SLPI have been demonstrated and they provide antiprotease activity with several types of serine proteases, including neutrophil elastase, cathepsin G, and trypsin [5].…”