Evaluation of Serum Iron Parameters among Men Performing Regular Physical Activity—A Preliminary Study

Zamelska, Klaudia; Rzepka, Mateusz; Olszewska−Słonina, Dorota; Woźniak, Alina; Szewczyk-Golec, Karolina; Hołyńska-Iwan, Iga

doi:10.3390/life13030670

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Some studies have shown an association between physical activity and iron biomarkers which differed between sexes. Zamelska et al in 2023 found that lower serum ferritin concentration concerns men with regular physical activity [ 37 ]. In our study, further adjustment for physical activity did not materially change our findings.…”

Section: Discussionmentioning

confidence: 99%

Potential Mediating Role of Iron Biomarkers in the Association of Sex With Glucose, Insulin, and Type 2 Diabetes

Khatami,

Lange,

Groothof

et al. 2024

Journal of the Endocrine Society

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Context Sex-specific prevalence and incidence of type 2 diabetes (T2D) have been reported, but the underlying mechanisms are uncertain. Objective In this study, we aimed to investigate whether iron biomarkers mediate the association between biological sex and glucose metabolism and the incidence of T2D. Methods We used data from the general population enrolled in the prospective Prevention of REnal and Vascular ENd-stage Disease study in Groningen, Netherlands. We measured ferritin, transferrin saturation (TSAT), hepcidin, soluble transferrin receptor (sTfR), fasting plasma glucose (FPG), fasting plasma insulin (FPI) levels, and incidence of T2D. We used multivariable regression and mediation analyses to investigate our hypothesis. All iron biomarkers, FPG, and FPI were log-transformed. Results The mean (SD) age of the 5,312 (51.3% female) individuals was 52.2 (11.6) years. Compared with males, females had lower FPG (β= -0.01; 95%CI = -0.02, -0.01) and FPI (β= -0.03; 95%CI = -0.05, -0.02) levels. Ferritin, hepcidin, and sTfR showed potential mediating effects on the association between sex and FPG, 21%, 5%, and 7.1%, respectively. Furthermore, these variables mediated 48.6%, 5.7%, and 3.1% of the association between sex and FPI, respectively. Alternatively, TSAT had a suppressive mediating role in the association of sex with FPG and FPI. The incidence of T2D was lower in females than in males (HR = 0.58; 95%CI = 0.44, 0.77), with 19.2% of this difference being mediated by ferritin. Conclusion Iron biomarkers may partially mediate the association between sex and glucose homeostasis. Future studies addressing the causality of our findings are needed.

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Section: Discussionmentioning

confidence: 99%

Potential Mediating Role of Iron Biomarkers in the Association of Sex With Glucose, Insulin, and Type 2 Diabetes

Khatami,

Lange,

Groothof

et al. 2024

Journal of the Endocrine Society

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Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations

Majewski,

Piwko,

Ordak

et al. 2024

JCM

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In recent years, a series of articles has been published concerning magnetic resonance imaging (MRI) studies in a group of patients exposed to manganism, specifically factory workers, welders, and individuals with liver diseases, as well as those abusing home-produced ephedrone. Some potential symptoms of manganese toxicity include motor disturbances, neurocognitive problems, sleep disorders, and psychosocial changes. Despite various publications on MRI research in individuals with an elevated risk of manganism, there is a noticeable absence of a comprehensive review in this field. The detection of the accumulation of manganese in the brain through MRI can confirm the diagnosis and guide appropriate treatment. Due to the high cost of determining manganese ion levels in biological material, an additional aim of the manuscript was to identify simple medical laboratory parameters that, when performed concurrently with MRI, could assist in the diagnosis of manganism. Among these types of parameters are the levels of bilirubin, magnesium, liver enzymes, creatinine, hemoglobin, and hematocrit.

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Indicators of iron metabolism in regular donors of blood platelets and plasma

Danilova,

Kovtunov,

Nazarova

et al. 2024

Gematologiâ i transfuziologiâ

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Introduction. The high frequency of medical withdrawals from donatio ns due to a decrease in hemoglobin levels and the negative impact on the motivation and return to donation of temporarily withdrawn individuals dictates the need to study the effect of exfusion of blood and its components on iron metabolism.Aim: to evaluate the iron metabolism indicators in regular donors of platelets and plasma.Materials and methods. 99 platelet donors and 90 blood plasma donors who regularly participated in donations were examined. The comparison group consisted of 158 healthy individuals who had not previously donated blood and its components. Hemoglobin concentration, hematocrit, erythrocyte count and erythrocyte indices were assessed. The concentration levels of ferritin, iron, transferrin in blood serum as well as the values of total and unsaturated iron-binding capacity of se rum were studied, and the saturation coefficient of transferrin was calculated.Results. In men who donated platelets, a statistically significant decrease in the red blood cells count (p = 0.001), hematocrit (p = 0.014) and ferritin concentration (p < 0.001) were found relative to those in the comparison group: 4.8×1012/l, 42.0 %, 28.9 ng/ml versus 5.0×1012/l, 44.0 %, 74.2 ng/ml respectively. In regular donors a significant increase in the medium of hemoglobin of red blood cells was noted: 30.8 pg (p = 0.008) and 31.4 pg (p < 0.001) in men and 30.2 pg (p = 0.030) and 31.0 pg (p < 0.001) in women with platelet and plasma exfusions respectively compared to 29.4 pg in men and 29.6 pg in women who participated in donation for the first time. In plasma donors of both sexes, the values of hemoglobin and its average concentration in the erythrocyte were significantly higher than in first-time donors: 154.0 g/l (p = 0.008), 35.7 g/dl (p < 0.001) and 138.0 g/l (p < 0.001), 35.2 g/dl (p < 0.001) versus 146.0 g/l, 33.6 g/dl and 129.0 g/l, 33.8 g/dl in men and women, respectively.Conclusion. To prevent the development of iron deficiency in donors of blood components it is necessary to monitor the con-centration of serum ferritin and correct its reduced values by changing the donation regimen or prescribing iron-containing drugs. When selecting donors, attention should be paid to the frequency of apheresis, especially in men who regularly donate platelets.

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Evaluation of Serum Iron Parameters among Men Performing Regular Physical Activity—A Preliminary Study

Cited by 3 publications

References 35 publications

Potential Mediating Role of Iron Biomarkers in the Association of Sex With Glucose, Insulin, and Type 2 Diabetes

Potential Mediating Role of Iron Biomarkers in the Association of Sex With Glucose, Insulin, and Type 2 Diabetes

Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations

Indicators of iron metabolism in regular donors of blood platelets and plasma

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