Evaluation of Serum Levels of Renin Angiotensin System Components in Asthmatic Patients

Abstract

Objective: Asthma is a chronic inflammatory lung disease. The renin-angiotensin system (RAS) targets several tissues and maintains fluid homeostasis. It is also known that RAS plays a role in inflammatory processes. Angiotensin-converting enzyme (ACE) and its product angiotensin II (AngII), which are the components of RAS, regulate the known effects of RAS. The other components of RAS, ACE2 and its product Ang 1-7, regulate the counter-effects of RAS. That is why the activation or inhibition of RAS can offer new therapeutic strategies for treating several diseases. We aimed to investigate the serum level of RAS components such as angiotensinogen (AGT), ACE, AngII, ACE2, and Ang 1-7 in asthma and control groups. Materials and Methods:This study was performed on 27 asthma and 23 healthy individuals. The serum levels of AGT, ACE, AngII, ACE2, and Ang 1-7 were measured by human enzyme-linked immunosorbent assay (ELISA) kits.Results: There were no statistically significant differences for the serum levels of AGT and ACE between the groups. The serum levels of AngII, ACE2, and Ang 1-7 were significanlty higher in the asthma group than those in the control group. Conclusion:Our results indicate that two tails of RAS, i.e., the ACE and ACE2 pathways, are activated in asthma compared to are activated more in the asthma group than in the control group. We suppose that the activation of ACE2 tail of RAS occurs because of the homeostatic balance requirements of this system. We believe that the activation of ACE2 pathway, in addition to the inhibition of the ACE pathway, can provide clinical benefits in treating asthma.

Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation

“…A similar change was observed for plasma Ang II ( Fig. 8 A ), which was consistent with a previous report ( Ayada et al, 2015 ). Importantly, there was a significant positive correlation between plasma Ang II and ILC2 proportion in asthmatic patients ( Fig.…”

The Possible Dual Role of the ACE2 Receptor in Asthma and Coronavirus (SARS-CoV2) Infection

“…IL-4 and IL-13, which are cytokines highly produced in Th2/eosinophilic asthma, can downregulate ACE2 expression in airway epithelial cells (Kimura et al, 2020;Song et al, 2020), whereas, TNF, IL-12, and IL-17A, which are cytokines highly produced in Th17/neutrophilic asthma and COPD (Alcorn et al, 2009), can upregulate ACE2 expression in in vitro BEAS-2B cells (Song et al, 2020). In addition, circulating soluble angiotensinconverting enzyme 2 (sACE2) is upregulated in the blood of asthmatic patients (Ayada et al, 2015); hence, sACE2 could act as a competitive interceptor, limiting SARS-CoV-2 attachment to airway cell membranes (Batlle et al, 2020).…”