Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus

Abstract

ObjectivePeople with type 2 diabetes are at an increased risk of hypertension, arteriosclerosis, heart disease, and stroke. Glucose intolerance (insulin resistance) is the main feature of type 2 diabetes. Obesity leads to insulin resistance, dyslipidemia, etc. The aim of this study was to assess the biochemical parameters and measures of obesity in type 2 diabetes mellitus (T2DM).MethodsA total of 2,273 males and 6,547 females previously healthy volunteers (aged 41–95 years old) were recruited by open invitation. The basic information, including age, sex, height, weight, body mass index (BMI), waistline, hipline, menstrual cycle, and medical history, was collected by questionnaire survey and physical examination. Serum lipid profile, liver transaminase, blood glucose, postprandial blood glucose, and hemoglobin A1c were obtained after 12 hours of fasting.ResultsAccording to our results, diabetic patients presented serum lipid abnormality. Elevated triglyceride (TG) levels (≥1.7 mmol/L) were noted in 19.69% of males and 20.40% of females, and reduced high-density lipoprotein cholesterol (HDL-C) levels (≤1.15 mmol/L) were noted in 21.96% of males and 15.74% of females. The combination of elevated TG and reduced HDL-C was the most prevalent of the combined lipid abnormalities. In contrast, no differences were observed in the levels of low-density lipoprotein cholesterol and total cholesterol. Moreover, there were statistically significant differences in the levels of BMI and waistline between T2DM and non-T2DM participants. After adjustment for BMI, logistic regression analysis revealed that the subjects with BMI ≤20 kg/m2 and >30 kg/m2 had a significantly elevated hazard ratio of T2DM compared with participants having a BMI range of 20–30 kg/m2 in both males and females. However, there was a significant difference between T2DM patients and non-T2DM patients in waistline (χ2=8.57, P<0.001) than in BMI parameter (χ2=6.29, P<0.001).ConclusionThe present study shows for the first time that low levels of HDL-C, high levels of TG, and abnormal levels in BMI and waistline increase the risk of type 2 T2DM in Chinese people.

Dyslipidaemia was correlated to the posterior circulation infarction in non-diabetic populations

“…Dyslipidaemia was prone to happening in the diabetic populations [ 17 , 18 ], which played important role in the pathogenesis of AIS. Insulin resistance (IR) existed in many diabetic population and altered the lipids and lipoprotein metabolism [ 6 , 19 , 20 ]. Through a series of signaling pathways adjusting, the decrease in HDL available for participation in reverse cholesterol transport may finally caused the atherogenicity in AIS [ 21 ].…”

“…Diabetes mellitus had obvious impact on the lipids, which mainly reflects in the rise of Triglyceride (TG) and fall of High density lipoprotein cholesterol (HDL-C) [ 6 , 7 ]. Both the blood glucose and lipids would play the important role on the occurrence of arteriosclerosis, while lipids would play the more direct role [ 8 , 9 ].…”

Multivariate analysis of genomics data to identify potential pleiotropic genes for type 2 diabetes, obesity and dyslipidemia using Meta-CCA and gene-based approach

“…These three disorders are closely connected. Firstly, clinical observation and epidemiological data show that a number of type 2 diabetes patients are obese with dyslipidemia before receiving intervention or therapy [ 9 ]. Secondly, these three disorders have common risk factors and pathophysiological bases.…”

Comparison of Glycemic Variability in Chinese T2DM Patients Treated with Exenatide or Insulin Glargine: A Randomized Controlled Trial

“…Standardized weight is an important part of integrated T2DM management because weight loss is associated with improvements in β-cell function and insulin action, it makes long-term glycemic control management easier, and it may favorably affect other comorbid diseases such as dyslipidemia, hypertension, and hyperuricemia [ 15 ]. An increasing waist circumference contributes to central obesity and is an independent risk factor for T2DM, dyslipidemia, hypertension, and CVD [ 26 , 37 ]. In the present study, waist circumference only decreased in the exenatide-treated group.…”