Evaluation of serum M30 and M65 activity in patients with stage-I endometrial cancer

Camuzcuoğlu, Aysun; Sezgin, Burak; Çelik, Hakim; Camuzcuoğlu, Hakan

doi:10.1080/01443615.2019.1586855

Cited by 2 publications

(4 citation statements)

References 24 publications

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“…Moreover, as in our previous and Wu's et al . study, high levels of apoptotic markers were found in early‐stage endometrial cancer 21,24 . However, as Driák et al .…”

Section: Discussionmentioning

confidence: 79%

“…23 Moreover, as in our previous and Wu's et al study, high levels of apoptotic markers were found in early-stage endometrial cancer. 21,24 However, as Driák et al stated in their study, premalignant and malignant states of endometrium are not affected merely by changes in apoptosis. 25 In the present study, the ratios of DNT and DTT were found to be significantly higher in the endometrial cancer group.…”

Section: Discussionmentioning

confidence: 84%

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Assessment of thiol disulfide balance in early‐stage endometrial cancer

Sezgin

Pirinççi

Camuzcuoğlu

et al. 2020

J of Obstet and Gynaecol

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Aim: We carried out this research to assess thiol disulfide balance in patients with early-stage endometrial cancer. Methods: Fifty-seven endometrial cancer patients and 60 age-matched healthy subjects volunteered for this study. Thiol disulfide parameters and the ratios of these parameters were examined using a colorimetric system. We also evaluated total antioxidant capacity, total oxidant capacity and oxidative stress index. Results: Subjects with endometrial cancer had statistically significantly lower serum native thiol and total thiol levels (224.2 [122.8-267.5] and 270.5 [171.6-323.2], respectively) than healthy subjects (281.35 [213.45-358.9] and 339. 55 [274.1-425.95], respectively) (P = 0.001, P < 0.001). Subjects with endometrial cancer had statistically significantly higher serum disulfide/native thiol and disulfide/total thiol ratios (12.22 [8.77-17.61] and 9.82 [7.46-13.02], respectively) than healthy subjects (8.9 [6.79-16.35] and 7.36 [5.9-12.32], respectively) (P = 0.038, P = 0.028). Disulfide/native thiol ratio appeared to be strongly and positively correlated with the stage of endometrial cancer (r = 0.827, P < 0.001). Conclusion: This is an initial report related to thiol disulfide balance in endometrial cancer patients. We believe that oxidative stress contributes both to the evolution and to the progression of the disease. We conclude that deterioration of thiol disulfide balance due to oxidative stress is likely to contribute to the etiopathogenesis of endometrial cancer.

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“…Moreover, as in our previous and Wu's et al . study, high levels of apoptotic markers were found in early‐stage endometrial cancer 21,24 . However, as Driák et al .…”

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 84%

Assessment of thiol disulfide balance in early‐stage endometrial cancer

Sezgin

Pirinççi

Camuzcuoğlu

et al. 2020

J of Obstet and Gynaecol

Self Cite

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“…It has been observed that antioxidative activity is reduced with increasing levels of oxidative stress markers in women with early-stage EC [ 13 ]. An analysis of the prognostic values of oxidative stress parameters (oxidative stress index OSI, total oxidant status TOS) and M30/65 apoptotic markers concentration in the blood serum of 52 women diagnosed with EC indicated that the markers were significantly higher in the sick patients, as compared to the control group, while the levels of antioxidative markers (total antioxidant status—TAS) in the serum were significantly lower [ 14 ]. Although impaired apoptotic activity plays a key role in EC aetiopathogenesis, oxidative stress may be a major factor in the malignant transformation.…”

Section: Oxidative Stress In Endometrial Cancermentioning

confidence: 99%

“…They are all diseases whose physiological markers entail functional disorders of the antioxidant system and progressing inflammation [ 10 , 11 , 12 ]. Moreover, given the fact that the physiological markers of EC also include antioxidative system disorders and inflammation [ 13 , 14 , 15 ], the primary form of dietary pharmacotherapy supplementation should involve foods rich in substances aiding the organism’s response to this type of disorder, in particular ones that are suitable for lifelong consumption. Tea satisfies those requirements thanks to its proven antioxidative, anti-inflammatory, anti-obesogenic, and antidiabetic properties.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer

Olcha

Winiarska-Mieczan

Kwiecień

et al. 2022

IJMS

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Endometrial cancer (EC) is second only to cervical carcinoma among the most commonly diagnosed malignant tumours of the female reproductive system. The available literature provides evidence for the involvement of 32 genes in the hereditary incidence of EC. The physiological markers of EC and coexisting diet-dependent maladies include antioxidative system disorders but also progressing inflammation; hence, the main forms of prophylaxis and pharmacotherapy ought to include a diet rich in substances aiding the organism’s response to this type of disorder, with a particular focus on ones suitable for lifelong consumption. Tea polyphenols satisfy those requirements due to their proven antioxidative, anti-inflammatory, anti-obesogenic, and antidiabetic properties. Practitioners ought to consider promoting tea consumption among individuals genetically predisposed for EC, particularly given its low cost, accessibility, confirmed health benefits, and above all, suitability for long-term consumption regardless of the patient’s age. The aim of this paper is to analyse the potential usability of tea as an element of prophylaxis and pharmacotherapy support in EC patients. The analysis is based on information available from worldwide literature published in the last 15 years.

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Evaluation of serum M30 and M65 activity in patients with stage-I endometrial cancer

Cited by 2 publications

References 24 publications

Assessment of thiol disulfide balance in early‐stage endometrial cancer

Assessment of thiol disulfide balance in early‐stage endometrial cancer

Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer

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