Evaluation of Serum Midkine as a Marker of Hepatocellular Carcinoma in Cirrhotic Patients

Elnakeeb, N.A; Khayyal, Ahmed E.; Osman, Mohamed Ramadan; ElGhandour, Ahmed Mohamed

doi:10.21608/ejhm.2020.105927

Cited by 1 publication

(1 citation statement)

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“…However, there was a statistically significant difference between group B and group A in terms of serum albumin and platelet count (P = 0.003, 0.001, respectively). These results were consistent with those of Elnakeeb et al [16] who reported that there were highly significant difference in serum levels of AST, ALT, Albumin, Bilirubin, PT and Platelet count with increased severity of liver function tests in HCC group more than other groups of the study (HCV cirrhotic patients without HCC and control group of apparently healthy subjects with no past history of HCC or HCV cirrhosis).…”

Section: Discussionsupporting

confidence: 92%

Hypovitaminosis D and Hepatocellular Carcinoma in Patients with Liver Cirrhosis

Rizk¹,

Mohamed²,

El-Alfy³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: The most frequent primary liver cancer in those with cirrhosis and chronic liver disease is hepatocellular carcinoma (HCC). Anti-infective and immune-modulating capabilities have been discovered for the multifunctional steroid hormone known as vitamin D. Vitamin D deficiency was found to be linked with advancement of Chronic liver disease (CLD) as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), as well as the hepatitis C virus (HCV). Objective: The aim of the current work was to investigate the association between vitamin D deficiency and HCC in patients with liver cirrhosis. Patients and Methods: Ninety individuals with liver cirrhosis (LC) participated in this trial. The included subjects were divided into two groups; Group A consisted of 45 cirrhotic patients without HCC, and Group B consisted of 45 cirrhotic patients with HCC. Results: Liver function tests: INR, ALT, AST, total bilirubin were all statistically substantially higher in group B than in group A (P=0.001, 0.001, 0.001, and 0.011, respectively). However, group B's serum albumin and platelet count were considerably lower than group A's (P=0.003 and 0.001, respectively) compared to each other. In comparison to group A's alphafetoprotein (AFP) of 8.69±1.84, group B's AFP of 254.33±32.69 was statistically substantially higher (P = 0.001).Vitamin D levels in group B were substantially lower (19.33±4.68) than in group A (26.31±4.95) (P= 0.00). With an area under the curve (AUC) of 0.802, vitamin D was significant at a cutoff level of ≤ 20.5 ng/ml with a sensitivity of 80.3% and a specificity of 75% for increasing the risk of HCC. Conclusion: It could be concluded that it is crucial to maintain an optimum blood level of vitamin D in cirrhotic individuals since our findings indicate a substantial correlation between vitamin D levels and HCC risk.

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Section: Discussionsupporting

confidence: 92%