Evaluation of serum Midkine as a novel biomarker for the diagnosis of hepatocellular carcinoma

Osman, Osama B.S.; Mohammed, Ebtsam F; Mahran, Zeinab G; Bakr, Asmaa; Mohareb, Dina A; Nasr, Esraa N. Abd-El Hakim

doi:10.4103/jcmrp.jcmrp_153_18

Cited by 2 publications

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“…This may be due to increased hepatocyte regeneration after HCVinduced cellular death.30 Fluctuating AFP levels in cirrhotic patients may reflect HCV exacerbation and flaring of the underlying liver disease. 31 In addition, high serum AFP level in HCC patients can be explained by the multiple roles of AFP in HCC progression associated with cellular proliferation, angiogenesis as well as apoptosis.32,33 It has been also reported that AFP can block the apoptotic pathway in HCC by binding to caspase-3.34 In addition, AFP has an immunosuppressive effect via inhibiting the proliferative ability of Tlymphocytes and natural killer cells. 35 The present study unveiled an important correlation in HCC patients between serum AREG level and portal vein thrombosis besides metastasis.…”

Section: Disscusionmentioning

confidence: 99%

Biochemical Studies on Amphiregulin protein in Hepatitis C virus patients

et al. 2023

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Background: Hepatocellular carcinoma (HCC) is the most common primary malignant liver cancer and the sixth most common form of cancer worldwide. The number of its patients are growing all over the world as it affects half a million patients yearly. The main indication of HCC is the secretion of Alfa Feto Protein which may be normal in only 40 % of its patients. Amphiregulin protein has been identified as one of the 10-gene signatures in close association with the occurrence of liver metastasis in colorectal cancer patients. The expression of AREG in normal livers is undetectable; however, it is induced during acute and chronic liver injury AREG is an early response growth factor during liver regeneration. It also contributes to the transformed phenotype of human hepatocellular carcinoma cells. Objectives: The aim of the study is biochemical investigation of amphiregulin protein in Hepatitis C virus patients. Patients and Methods: This study involved 90 participants in 3 groups: Group (1): Control group composed of 30 healthy subjects. Group (2): Cirrhosis group which is composed of 30 patients with chronic liver disease (cirrhosis). Group (3): HCC group which is composed of 30 patients with hepatocellular carcinoma on top of HCV-related liver cirrhosis. All patients were subject to an assessment of AFP and AREG. Besides, HCC patients went clinically through a full estimation of liver biochemical profile, viral indications, and finally US and triphasic abdominal CT. Results: There is a statistically significantly higher age, Amphiregulin, AST, and INR in HCC > cirrhosis > control. AFP was statistically significantly higher in HCC and cirrhosis vs. control. Though, AFP was higher in HCC vs. control, and this difference was not statistically significant. There is a statistically significantly lower serum albumin in HCC > cirrhosis > control. WBCs and platelet counts were statistically significantly lower in HCC vs. cirrhosis. There is statistically significantly higher ALT and total bilirubin in HCC and cirrhosis vs. control, and a statistically significantly lower hemoglobin level in HCC and cirrhosis vs. control. Conclusion: The result exhibit There is the diagnostic performance is good for AREG and when use to gather with AFP is perfect.

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Section: Disscusionmentioning

confidence: 99%