Evaluation of Serum Superoxide Dismutase Activity, Malondialdehyde, and Zinc and Copper Levels in Patients With Keratoconus

Kılıç, Raşit; Bayraktar, Aslihan Cavunt; Bayraktar, Serdar; Kurt, Ali; Kavutçu, Mustafa

doi:10.1097/ico.0000000000001018

Cited by 19 publications

(12 citation statements)

References 28 publications

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“…A 2012 study found increased superoxide dismutase (SOD) and reduced MMP-2 and zinc in KC patient blood (Ortak et al, 2012). However, this conflicts with a 2016 report which found no difference in SOD activity, although zinc was reduced in their cohort as well, corroborating a potential role for zinc deficiency (Kilic et al, 2016). Prolidase was found to be reduced in KC patient blood in a 2015 study which also found elevated oxidative stress markers (Goncu et al, 2015).…”

Section: Discussionmentioning

confidence: 97%

Prolactin-Induced Protein is a novel biomarker for Keratoconus

Sharif

Bak‐Nielsen

Sejersen

et al. 2019

Experimental Eye Research

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Purpose-The purpose of the study was to investigate the role of Prolactin-Induced Protein (PIP) as a predictive biomarker for Keratoconus (KC). Participants-This study included one hundred and forty-seven patients with KC (105 male, 42 female), and sixty healthy controls (27 male, 33 female). Methods-Tears, plasma and saliva samples were collected from all participants. In both KC and healthy groups all collected samples were divided into four age subgroups (15-24y), (25-34y), (35-44y) and (45y and up). Samples were analyzed using western blot (WB) and enzyme-linked immunosorbent assay (ELISA). Areas under the receiver operating characteristic curves (AUROCs) were used to evaluate diagnostic accuracy for distinguishing between KC and healthy eyes.

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Section: Discussionmentioning

confidence: 97%

Prolactin-Induced Protein is a novel biomarker for Keratoconus

Sharif

Bak‐Nielsen

Sejersen

et al. 2019

Experimental Eye Research

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“…Fenton reaction can generate the highly ROS implicating metals as iron or cupper increased in samples of keratoconus (iron ring at the basis of cone entitled Fleischer sign) (Rabinowitz 1998; Kiliç et al. 2016; Bamdad et al. 2018; Zarei‐Ghanavati et al.…”

Section: Discussionmentioning

confidence: 99%

Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis

Navel

Malecaze

Pereira

et al. 2020

Acta Ophthalmologica

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Purpose To conduct a systematic review and meta‐analysis on the levels of oxidative stress markers and antioxidants in keratoconus compared to healthy subject. Method The PubMed, Cochrane Library, Embase, Science Direct and Google Scholar databases were searched on 1st June 2020 for studies reporting oxidative and antioxidative stress markers in keratoconus and healthy controls. Main meta‐analysis was stratified by type of biomarkers, type of samples (tears, cornea, aqueous humour and blood) and type of corneal samples (stromal cells, epithelium and endothelium). Results We included 36 articles, for a total of 1328 keratoconus patients and 1208 healthy controls. There is an overall increase in oxidative stress markers in keratoconus compared with healthy controls (standard mean deviation (SMD) = 0.94, 95% confidence interval (95% CI) 0.55–1.33), with a significant increase in reactive oxygen and nitrogen species (1.09, 0.41–1.78) and malondialdehyde (1.78, 0.83–2.73). There is an overall decrease in antioxidants in keratoconus compared with healthy controls (−0.63, −0.89 to −0.36), with a significant decrease in total antioxidant capacity/status (−1.65, −2.88 to −0.43), aldehyde/NADPH dehydrogenase (−0.77, −1.38 to −0.17), lactoferrin/transferrin/albumin (−1.92, −2.96 to −0.89) and selenium/zinc (−1.42, −2.23 to −0.61). Oxidative stress markers were higher in tears and in cornea of keratoconus than in aqueous humour, and antioxidants were decreased in tears, aqueous humour and blood without difference between sample type. Oxidative stress markers increased in stromal cells and antioxidants decreased in endothelium. Conclusion Oxidative stress markers and antioxidants were dysregulated in keratoconus, involving an imbalance of redox homeostasis in tears, cornea, aqueous humour and blood.

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“…In line with this hypothesis, KC patients display lower serum levels of Cu, Se, and Zn [46,[59][60][61]. Moreover, Cu deficiency can be exacerbated in KC by increased tear alkalinity.…”

Section: Mineralsmentioning

confidence: 77%

Nutritional and Metabolic Imbalance in Keratoconus

et al. 2022

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Keratoconus (KC) is a progressive corneal degeneration characterized by structural changes consisting of progressive thinning and steepening of the cornea. These alterations result in biomechanical weakening and, clinically, in vision loss. While the etiology of KC has been the object of study for over a century, no single agent has been found. Recent reviews suggest that KC is a multifactorial disease that is associated with a wide variety of genetic and environmental factors. While KC is typically considered a disease of the cornea, associations with systemic conditions have been well described over the years. In particular, nutritional and metabolic imbalance, such as the redox status, hormones, metabolites, and micronutrients (vitamins and metal ions), can deeply influence KC initiation and progression. In this paper, we comprehensively review the different nutritional (vitamins and minerals) and metabolic (hormones and metabolites) factors that are altered in KC, discussing their possible implication in the pathophysiology of the disease.

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Evaluation of Serum Superoxide Dismutase Activity, Malondialdehyde, and Zinc and Copper Levels in Patients With Keratoconus

Abstract: There is imbalance in the systemic oxidant/antioxidant status where Zn deficiency also plays a role in patients with keratoconus.

Cited by 19 publications

References 28 publications

Prolactin-Induced Protein is a novel biomarker for Keratoconus

Prolactin-Induced Protein is a novel biomarker for Keratoconus

Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis

Nutritional and Metabolic Imbalance in Keratoconus

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