Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS)

Ślebioda, Zuzanna; Krawiecka, Ewa; Szponar, Elżbieta; Dorocka‐Bobkowska, Barbara

doi:10.1186/s12903-017-0450-x

Cited by 22 publications

(17 citation statements)

References 28 publications

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“…Serum zinc concentration indicates recent consumption of zinc or regular zinc intake, indicating that, in populations with low zinc diet, the serum zinc level is lower, which shows a high zinc deficiency risk. These studies showed that, the best time to measure serum zinc is whilst fasting in morning [ 23 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Individuals suffering from other mucosal disease such as oral lichen planus, recurrent aphthous stomatitis, xerostomia and burning mouth syndrome have also been recognized as having lower serum zin concentrations compared to healthy individuals [ 28 , 33 ]. In the case of other viral diseases and body minerals, in a study conducted by Okwara et al [ 34 ], 51 adult patients with human immunodeficiency viral infection (HIV) and 48 healthy people were included.…”

Section: Discussionmentioning

confidence: 99%

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Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

et al. 2020

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Background Recurrent herpes labialis (RHL) is a common recurrent infective vesiculoulcerative disease. Topical and systemic administration of Zinc compounds has been indicated to have preventive and therapeutic effects. The purpose of this study was to evaluate the serum level of zinc in the patients with RHL and healthy individuals and also to investigate the correlation of this level with various parameters of the patient and disease course. Methods This cross-sectional study was performed on 43 patients with a history of recurrent herpers labialis and 42 subjects without any previous experience of the lesion. Blood samples were taken, and serum zinc level was measured using colorimetry (spectrophotometry) method. Chi-Square test was used to compare the qualitative relationships, and for comparing the quantitative relationships, independent T-test was used. To observe the relationship of quantitative factors including serum zinc level, the number of relapses, and recovery rates, correlation test was taken. Results The results show that, serum zinc level has no significant difference between healthy subjects and the patients (p > 0.05). Also, zinc level was not related to age and sex factors and frequency of relapse (p > 0.05). However surprisingly, there was a significant relationship between zinc level and recovery period in the RHL patients. The lower the serum zinc level, the higher the duration of recovery (p = 0.009). Conclusion The results of this study indicate that, zinc deficiency can be considered as a risk factor for increasing the duration of herpes labialis lesions. Therefore, the evaluation of serum zinc level in the subjects with RHL and subsequent administration of zinc are recommended in these kind of patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

et al. 2020

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“…Other agents like zinc supplements have also been reported in the recovery of aphthous ulcers [10]. However, based on several clinical trials, it seems that systemic zinc supplement therapy in RAS is still a matter of debate [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of zinc sulfate mucoadhesive formulation on recurrent aphthous stomatitis: a randomized double-blind, placebo-controlled clinical trial

et al. 2020

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Background: Recurrent aphthous stomatitis (RAS) is a common lesion that affects the oral mucosa. There are several methods to treat RAS, including systemic and topical formulations. This study was conducted to evaluate the anti-inflammatory effect of topical zinc sulfate and its efficacy in the treatment of RAS. Methods: A double-blind randomized clinical trial was conducted on 46 patients with RAS. They were randomly assigned into two groups to receive a zinc sulfate mucoadhesive tablet or placebo for 7 days. The pain severity was measured at baseline and daily while the diameter of the lesion was measured at baseline and on days 3, 5, and 7. The obtained data were analyzed in SPSS V.16. Results: There was no significant difference in the mean diameter of lesions and pain at baseline between the two groups (P = 0.643 and P = 0.842, respectively). However, on the third, fifth, and seventh days of the study, the diameter of the lesion significantly reduced in the intervention group (P = 0.001) and the pain intensity became significantly different between groups from the fourth day of the study (P = 0.001). Conclusion: Zinc sulfate mucoadhesive tablet was effective in recovery and reducing the pain and diameter of the aphthous lesion and could be considered for the treatment of RAS. Trial registration: Evaluation of the effectiveness of zinc sulfate mucoadhesive tablet in the improvement of recurrent aphthous stomatitis (RAS), IRCT20151109024975N9.

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“…These studies showed that the best time to measure serum zinc was whilst fasting in morning. (17,23) In another article, published by Femiano et al in 2005, they examined the effect of zinc on RHL. In this paper, 20 patients (including 12 women and 8 men) with an average age of 26.6 with a history of RHL more than 6 times per year and a recovery period of more than 8-14 days were treated with zinc sulfate 22.5 mg twice daily for 4 months.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

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Zahed

Ranjbar

et al. 2020

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Background: Recurrent herpes labialis (RHL) is one of the most common recurrent infective vesiculoulcerative lesions. Topical and systemic administration of Zinc compounds has been found to have preventive and therapeutic effects. The purpose of this article is to evaluate the serum level of zinc in patients with RHL and healthy individuals.Methods: This cross-sectional study was performed on 43 patients with the history of recurrent herpers labialis and 42 healthy subjects with no history of the lesion. Blood samples were taken and serum zinc level was measured. Chi-Square test was used to compare the qualitative relationships and to compare the quantitative relationships independent T-test was used. To observe the relationship of quantitative factors including serum zinc level, the number of relapses and recovery rates correlation test was taken.Results: The results show that serum zinc level has no significant difference in healthy subjects and patients (p> 0.05). Also, zinc level was not related to age and sex factors and frequency of relapse (P> 0.05). But surprisingly in the patients group, there was a significant relationship between zinc level and recovery period. As the serum zinc level was lower, the duration of recovery was significantly higher (p =0.009). Conclusion:The results of this study indicate that zinc deficiency is a risk factor for increasing the duration of herpes labialis lesions. Therefore, the evaluation of serum zinc level in subjects with recurrent herpes labialis and subsequent administration of zinc is recommended in such patients. Background:Herpes simplex virus type 1 (HSV-1) a member of the herpes virus family is the etiologic factor of a variety of diseases. It generally affects the upper parts of the human body. The primary infection appears after fluid or skin contact with contaminated individuals. The virus tends to remain in the sensory ganglions or skin epithelium after the initial infection, in most cases. Factors such as sunlight, shock, stress, fever, and hormonal changes can trigger a secondary or recurrent lesion such as herpes labialis.(1, 2) Herpes labialis appears primarily as a vesicle in the skin area around the oral cavity, lips, nose or the

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Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS)

Cited by 22 publications

References 28 publications

Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

Evaluation of zinc sulfate mucoadhesive formulation on recurrent aphthous stomatitis: a randomized double-blind, placebo-controlled clinical trial

Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

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