Evaluation of Serum Zinc Status and Glycated Hemoglobin of Type 2 Diabetes Mellitus Patients in a Tertiary Care Hospital of Assam

From many points of view, zinc is one of the most important trace elements in biological systems. Many articles describe the well-known role of this metal in human physiology and pathophysiology, but in the related literature, there is a lack of current and reliable reviews of the role of zinc deficiency in many diseases. In this article, we describe the role of zinc deficiency in the oxidative stress control, immune response, proliferation, and pathogenesis and pathophysiology of selected diseases such as depression, cardiovascular diseases, diabetes mellitus, Alzheimer’s disease, and Wilson’s disease.

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“…However, in type-1 diabetes, studies have reported a negative effect of zinc supplementation on glucose homeostasis [104]. …”

Section: Deficiency Of Zinc In Diabetes Mellitusmentioning

confidence: 99%

Biological consequences of zinc deficiency in the pathomechanisms of selected diseases

et al. 2014

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“…In the present study cohort with prediabetes, baseline serum zinc concentrations at the initiation of the clinical trial were below normal. The presence of hypozincemia in established T2DM has been demonstrated by numerous studies, and zinc deficiency is postulated to be at least partially responsible for the high diabetes epidemicity observed in developing countries, especially in the Asia–Pacific region . However, whether hypozincemia precedes diabetes or vice versa (i.e.…”

Section: Discussionmentioning

confidence: 99%

Zinc supplementation in prediabetes: A randomized double‐blind placebo‐controlled clinical trial

Ranasinghe

Wathurapatha

Galappatthy

et al. 2018

Journal of Diabetes

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“…1 According to the data published by International Diabetes Federation in their 5th edition of Diabetes Atlas, people living with diabetes is expected to rise from 366 million in 2011 to 552 million by 2030. 2 It is identified that zinc plays an important role in synthesis, storage and secretion of insulin in response to carbohydrate intake and plays an important role in energy production. It also maintains the structural integrity of insulin.…”

Section: Introductionmentioning

confidence: 99%

Study of serum Zinc status among type 2 diabetes mellitus patients

et al. 2017

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Background: Both microvascular and macrovascular complications in diabetes are related to oxidative stress. Zinc which has antioxidant property, delays diabetic complications. The present study was conducted with the objective to study the relationship between serum Zinc level and HbA1C level in newly diagnosed type 2 diabetes mellitus and to compare serum Zinc level with its risk factors. Methods: The present study was a cross sectional study, conducted on 100 patients attending the outpatient department at Rajiv Gandhi Government General Hospital and Madras Medical College, Chennai during the period from May 2015 to October 2015. Of them 50 were newly diagnosed type 2 diabetics and considered as diabetic group and other 50 were considered as controls, who attended the master health check-up. All patients were subjected to thorough general and systemic examination. Under strict aseptic precautions blood sample was collected from all the patients and the serum was investigated for creatinine, urea, zinc, HbA1c, cholesterol, triglycerides and fasting blood glucose. The data obtained were analysed using Microsoft excel software. Correlation was found out in SPSS by using regression equation. Results: The body mass index (BMI) and mean systolic blood pressure (SBP) was significantly higher (p<0.001) in diabetic group as compared to controls. Serum levels of HbA1C and fasting blood glucose (FBG) levels were found to be significantly higher in diabetic group than in controls (p<0.001). Serum zinc levels were significantly higher in control group (p<0.001). Mean zinc value decreases with increase in HbA1c, FBG, BMI, SBP, DBP, triglycerides and cholesterol and the difference was statistically significant (p value <0.01). The relation between Pearson correlation coefficient for zinc and the above parameters were higher in diabetics than controls. Conclusions: Lower serum zinc levels were found to be responsible for the development of macrovascular complications in type-2 diabetics. Hence there is a need for zinc supplementation in diabetic patients to prevent long term complications associated with it.

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Evaluation of Serum Zinc Status and Glycated Hemoglobin of Type 2 Diabetes Mellitus Patients in a Tertiary Care Hospital of Assam

Cited by 27 publications

References 21 publications

Biological consequences of zinc deficiency in the pathomechanisms of selected diseases

Biological consequences of zinc deficiency in the pathomechanisms of selected diseases

Zinc supplementation in prediabetes: A randomized double‐blind placebo‐controlled clinical trial

Study of serum Zinc status among type 2 diabetes mellitus patients

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