Evaluation of sesame (Sesamum indicum L.) germplasm collection of Tamil Nadu for -linolenic acid, sesamin and sesamol content

Chellamuthu, Muthulakshmi; Sekar, P.; Subramanian, Selvi

doi:10.5897/ajb2016.15688

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…Wang et al [ 16 ] reported that seed sesamin and sesamolin mainly ranged from 0.88~11.05 mg/g and 0.93~6.96 mg/g, respectively, in a core collection conserved in China. In some Indian and Thai germplasms, seed sesamin ranged from 0.08~6.45 mg/g and 1.63~7.23 mg/g, respectively, and sesamolin from 0.28~3.76 mg/g and 0.48~2.25 mg/g, respectively [ 19 , 40 , 41 ]. The phenotype data from the two locations showed a significant positive correlation between sesamin and sesamolin content.…”

Section: Discussionmentioning

confidence: 99%

Fine Mapping of a Major Pleiotropic QTL Associated with Sesamin and Sesamolin Variation in Sesame (Sesamum indicum L.)

Zhou

Dossou

et al. 2021

Plants

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Deciphering the genetic basis of quantitative agronomic traits is a prerequisite for their improvement. Herein, we identified loci governing the main sesame lignans, sesamin and sesamolin variation in a recombinant inbred lines (RILs, F8) population under two environments. The content of the two lignans in the seeds was investigated by HPLC. The sesamin and sesamolin contents ranged from 0.33 to 7.52 mg/g and 0.36 to 2.70 mg/g, respectively. In total, we revealed 26 QTLs on a linkage map comprising 424 SSR markers, including 16 and 10 loci associated with sesamin and sesamolin variation, respectively. Among them, qSmin_11.1 and qSmol_11.1 detected in both the two environments explained 67.69% and 46.05% of the phenotypic variation of sesamin and sesamolin, respectively. Notably, qSmin11-1 and qSmol11-1 were located in the same interval of 127-127.21cM on LG11 between markers ZMM1776 and ZM918 and acted as a pleiotropic locus. Furthermore, two potential candidate genes (SIN_1005755 and SIN_1005756) at the same locus were identified based on comparative transcriptome analysis. Our results suggest the existence of a single gene of large effect that controls expression, both of sesamin and sesamolin, and provide genetic information for further investigation of the regulation of lignan biosynthesis in sesame.

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Section: Discussionmentioning

confidence: 99%

Fine Mapping of a Major Pleiotropic QTL Associated with Sesamin and Sesamolin Variation in Sesame (Sesamum indicum L.)

Zhou

Dossou

et al. 2021

Plants

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“…These authors found that white sesame seeds had higher levels of lignans than the other sesame genotypes. Likewise Shi et al [ 77 ], Dar et al [ 60 ], Muthulakshmi et al [ 78 ], and Kim et al [ 74 ] found that black-colored seeds contained larger quantities of sesamin and sesamolin contents. Dar et al [ 79 ] reported an average sesamolin content of 1.56–3.28 mg/g in black sesame, slightly higher than the range of 0.46–1.67 mg/g found in the present study.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Water Stress on Bioactive Compounds in Australian-Grown Black Sesame

Hoyos,

Johnson,

Mani

et al. 2024

Plants

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Sesame is an emerging crop of interest in Australia and has attracted widespread interest due to the health-benefitting properties of its bioactive compounds, including fatty acids, lignans, and polyphenols. This study aimed to investigate the impact of drought stress on these bioactive compounds, using eleven cultivars of black sesame seeds grown in Australia. Specific varieties responded positively to water deficit (WD) conditions, showing increased levels of TPC, FRAP, CUPRAC, and lignans. Varieties 1, 4, 7, and 12 showed significantly increased FRAP values ranging from 158.02 ± 10.43 to 195.22 ± 9.63 mg TE/100 g DW in the WD treatment compared to the well-watered (WW) treatment, whereas varieties 7, 10, 12, 13, and 18 demonstrated the highest CUPRAC values of all varieties (2584.86 ± 99.68–2969.56 ± 159.72 mg TE/100 g) across both WW and WD conditions, with no significant variations between irrigation regimes. Moreover, lignan contents (sesamin and sesamolin) were higher in varieties 1, 2, 5, and 8 grown in WD conditions. Compared to the optimal unsaturated to saturated fatty acid ratio (Σ UFA/Σ SFA ratio) of 0.45, all sesame genotypes showed superior ratios (ranging between 1.86 and 2.34). Moreover, the ω-6/ω-3 PUFA ratio varied from 33.7–65.5, with lower ratios in varieties 2, 4, 5, 8, and 18 under WD conditions. The high levels of phenolic compounds and healthy fats suggest the potential of black sesame to be incorporated into diets as a functional food. Furthermore, the enhanced phytochemistry of these cultivars in WD conditions is promising for widespread adoption. However, larger trial studies to confirm these findings across different geographic locations and seasons are warranted.

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“…[14] Sesame seed is a rich source of dietary lignans. [15] Lignan (sesamol, sesamin, and sesamolin) profile was identified in sesame seeds. [16][17] SM is the main reason for the oxidative stability of sesame seed oil.…”

Section: Introductionmentioning

confidence: 99%

Sesamol and its derivative investigated as antiandrogen - A potential prevention to prostate cancer in rats

Shah

et al. 2021

Preprint

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Androgen signaling is essential for the development of prostate cancer (PCa) initiated from prostatic basal cells with collocation of androgen receptor gene mutations. Phytoestrogens, the naturally occurring compounds are AR antagonist. These compounds downregulate prostate-specific antigen (PSA) expression and cell proliferation. Thus, this gives a track to research these compounds as a possible treatment for PCa. In this work, STITCH and molecular docking predict the conformation of ligands inside the suitable target binding site. Therefore, a study was planned to know the interactions among SM and its derivatives with AR. It was further, evaluated for in vitro evaluation on LNCaP, PC-3, and DU-145 using MTT studies. The two lead compounds shortlisted from MTT studies were further analyzed for androgen-regulated genes by using RT-PCR, western blot studies and an animal model of prostate cancer. We found that SM and its derivative (3’-MA) may prevent the development of PCa by androgen pathway.

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Evaluation of sesame (Sesamum indicum L.) germplasm collection of Tamil Nadu for -linolenic acid, sesamin and sesamol content

Cited by 9 publications

References 23 publications

Fine Mapping of a Major Pleiotropic QTL Associated with Sesamin and Sesamolin Variation in Sesame (Sesamum indicum L.)

Fine Mapping of a Major Pleiotropic QTL Associated with Sesamin and Sesamolin Variation in Sesame (Sesamum indicum L.)

The Effect of Water Stress on Bioactive Compounds in Australian-Grown Black Sesame

Sesamol and its derivative investigated as antiandrogen - A potential prevention to prostate cancer in rats

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