Evaluation of sesamum gum as an excipient in matrix tablets

Abstract

In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated.

The use of visible and UV dissolution imaging for the assessment of propranolol hydrochloride in liquisolid compacts of Sesamum radiatum gum

“…Here, the authors focus on a polysaccharide that has been extracted and characterised in our lab (Sesamum radiatum) and reported (Nep et al, 2016a). Sesamum gum is a very abundant natural polymer extracted from the leaves of Sesamum radiatum and has been reported for having the potential for retarding drug release from matrix systems as well as having the ability to withstand hydroalcoholic media effects (Ngwuluka, Nep, Ochekpe, Odumosu, & Olorunfemi, 2014;Nep et al, 2016;2018). It has also been used to improve the dissolution behaviour of ibuprofen and as a binder (Shaboun et al, 2018;Allagh et al, 2005).…”

Hydro-alcoholic media effects on theophylline release from sesamum polysaccharide gum matrices

“…(insert Figure 4 near here). This suggests that SGp is a highly compactible polymer as it formed the hardest compacts relative to HPMCp matrices [21,22]. In addition, there was a reduction in the porosity, and hardness of formulated compacts (SGf and HPMCf) relative to their pure polymers.…”

“…Gum from the leaves of Sesamum indicum have been evaluated as a binder in paracetamol tablets [18] and as matrix former in tablet formulations [19]. In addition, the binding properties of gum [20] extracted from its closest specie -Sesamum radiatum and its matrices has been reported [21]. The structural properties of Sesamum radiatum gum (SG) has been elucidated and it showed that the gum from the leaves of this plant is a branched glucuronomannan [22].…”

Mechanical and release behaviour of theophylline from matrix tablets containing psyllium powder in combination with grewia polysaccharides

“…Transport across this layer is by diffusion, but erosion can also occur when the polymer chains begin to untangle, as this happens the drug begins to be released [3]. The natural polymers have been used as matrices for sustained release [4][5][6][7][8][9][10][11][12] stabilizers or suspending agents in liquid dosage forms [13] and in bioadhesive drug delivery systems [14,15]. Apart from the fact that the natural materials are biocompatible, they have the additional advantages of being low cost and relatively abundant [16][17][18] compared to their synthetic counterparts.…”