Evaluation of Shape of Foveal Avascular Zone by Optical Coherence Tomography Angiography in Eyes With Branch Retinal Vein Occlusion

Shiihara, Hideki; Terasaki, Hiroto; Sonoda, Shozo; Kakiuchi, Naoko; Sakamoto, Taiji

doi:10.1177/2474126418764977

Cited by 6 publications

(8 citation statements)

References 40 publications

(63 reference statements)

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“…OCT angiography (OCTA) is a new imaging technology that can obtain the images of the retinal vasculature non-invasively. The foveal avascular zone (FAZ) is a circular area with a diameter of 500 µm where the retinal capillaries are absent 11 , 12 . The clinical value of FAZ on OCTA has been extensively explored in many retinal diseases 11 – 15 .…”

Section: Introductionmentioning

confidence: 99%

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Association of foveal avascular zone with the metamorphopsia in epiretinal membrane

Shiihara

Terasaki

Sonoda

et al. 2020

Sci Rep

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This study was to investigate the relationship between the metamorphopsia and foveal avascular zone (FAZ) parameter in eyes with epiratinal membrane (ERM). We studied patients with an ERM visited retinal service unit at the Kagoshima University Hospital or Shirai Hospital. The best-corrected visual acuity (BCVA), and the degree of metamorphopsia by M -CHARTS™ were evaluated. The 3 × 3 mm optical coherence tomography angiography (OCTA) images of the superficial layer were obtained. Area (mm2), the circularity, eigen value were calculated using ImageJ software. The relationship between visual function, such as best corrected visual acuity (BCVA) and metamorphopsia, and FAZ parameters were studied by Pearson’s correlational coefficient. Fifty-four eyes of 51 patients (24 men and 27 women) with an ERM were studied. The mean age of the patients was 69.6 ± 8.20 years. The mean BCVA and metamorphopsia score was 0.31 ± 0.29 logMAR units and 0.49 ± 0.42. There was no significant relationship between BCVA and FAZ parameters. While, metamorphopsia score was significantly and negatively correlated with all of FAZ parameters (area R = − 0.491, P < 0.001; circularity R = − 0.385, P = 0.004; eigenvalue ratio R = − 0.341; P = 0.012). Multiple regression analysis showed the FAZ area was solely and significantly correlated with metamorphopsia score (β − 0.479, P < 0.001). The size but not the shape of the FAZ was significantly correlated with the degree of metamorphopsia suggesting that it could be an objective parameter of metamorphopsia in ERM patients.

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Section: Introductionmentioning

confidence: 99%

“…The foveal avascular zone (FAZ) is a circular area with a diameter of 500 µm where the retinal capillaries are absent 11 , 12 . The clinical value of FAZ on OCTA has been extensively explored in many retinal diseases 11 – 15 . There are several reports on FAZ in ERM 16 – 19 .…”

Section: Introductionmentioning

confidence: 99%

Association of foveal avascular zone with the metamorphopsia in epiretinal membrane

Shiihara

Terasaki

Sonoda

et al. 2020

Sci Rep

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“…The indices chosen to characterize the FAZ geometry were area, axial ratio, circularity, and roundness. 23,25 Circularity is a shape descriptor that can mathematically indicate the degree of similarity of the FAZ to a perfect circle. A value of 1.0 designates a perfect circle; thus, as the circularity value decreases, the shape is increasingly less circular.…”

Section: Geometric/morphologic Parameters Of the Foveal Avascular Zonementioning

confidence: 99%

“…The use of FAZ area as a biomarker for retinal diseases has been extensively studied in the literature. [21][22][23] However, measurements of even normal FAZ size can have large intersubject variability that correlates with a patient's age, sex, axial length, refractive error, and central macular thickness. 24 Foveal avascular zone geometry has been demonstrated to display good reproducibility and repeatability in normal subjects, possibly being a more reliable tool to detect vascular alterations when evaluating the SCP.…”

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confidence: 99%

Optical Coherence Tomography Angiography Morphology After Rhegmatogenous Retinal Detachment Repair

Melo¹,

Francisconi²,

Marafon³

et al. 2023

Retina

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Purpose: To compare foveal avascular zone (FAZ) geometric indices using optical coherence tomography angiography (OCTA) in pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). FAZ morphology was assessed as a possible imaging feature of retinal displacement.Methods: This ALIGN post hoc analysis included primary fovea-off RRDs that underwent successful PnR or PPV, and performed OCTA, and fundus autofluorescence at (FAF) 3 months postoperatively at St. Michael's Hospital, Toronto, Canada. FAZ area (mm 2 ), axial ratio, circularity, and roundness were measured, and FAF images were assessed for retinal displacement.Results: Seventy-two patients were included, 78% (56/72) were male mean age was 60 6 9 years, and 60% (43/72) were phakic. Sixty-five percent (47/72) and 35% (25/72) underwent PnR and PPV, respectively. The mean baseline logarithm of the minimum angle of resolution visual acuity was 1.49 6 0.76. FAZ circularity was lower after PPV (0.629 6 0.120) versus PnR (0.703 6 0.122); P = 0.016. Sixty-six patients had gradable FAF images. Retinal displacement was present in 29% (19/66), 84.2% (16/19) of which had displacement in the macula. FAZ circularity was lower in eyes with displacement in the macula (0.613 6 0.110) versus those without displacement (0.700 6 0.124); P = 0.015. There was a moderate negative correlation between 12-month aniseikonia and FAZ circularity(r = 20.262; P = 0.041).Conclusion: FAZ circularity was lower after PPV and in eyes with retinal displacement in the macula. Circularity was negatively correlated with 12-month aniseikonia scores. FAZ circularity may be another imaging feature to consider postoperatively after RRD repair.

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“…Using OCTA, Shiihara et al [129] studied the relationship between morphological parameters (axial ratio and acircularity index) of the FAZ and BCVA in eyes with BRVO. Results demonstrated that acirculatory index is not significantly correlated to BCVA in RVO.…”

Section: Retinal Vein Occlusionmentioning

confidence: 99%

A Comprehensive Review of Retinal Vascular and Optical Nerve Diseases Based on Optical Coherence Tomography Angiography

et al. 2021

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The optical coherence tomography angiography (OCTA) is a noninvasive imaging technology which aims at imaging blood vessels in retina by studying decorrelation signals between multiple sequential OCT B-scans captured in the same cross section. Obtaining various vascular plexuses including deep and superficial choriocapillaris, is possible, which helps in understanding the ischemic processes that affect different retina layers. OCTA is a safe imaging modality that does not use dye. OCTA is also fast as it can capture high-resolution images in just seconds. Additionally, it is used in the assessment of structure and blood flow. OCTA provides anatomic details in addition to the vascular flow data. These details are important in understanding the tissue perfusion, specifically, in the absence of apparent morphological change. Using these anatomical details along with perfusion data, OCTA could be used in predicting several ophthalmic diseases. In this paper, we review the OCTA techniques and their ability to detect and diagnose several retinal vascular and optical nerve diseases, such as diabetic retinopathy (DR), anterior ischemic optic neuropathy (AION), age-related macular degeneration (AMD), glaucoma, retinal artery occlusion and retinal vein occlusion. Then, we discuss the main features and disadvantages of using OCTA as a retinal imaging method.

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Evaluation of Shape of Foveal Avascular Zone by Optical Coherence Tomography Angiography in Eyes With Branch Retinal Vein Occlusion

Cited by 6 publications

References 40 publications

Association of foveal avascular zone with the metamorphopsia in epiretinal membrane

Association of foveal avascular zone with the metamorphopsia in epiretinal membrane

Optical Coherence Tomography Angiography Morphology After Rhegmatogenous Retinal Detachment Repair

A Comprehensive Review of Retinal Vascular and Optical Nerve Diseases Based on Optical Coherence Tomography Angiography

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