Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions

Joseph, Sonja; Bunjes, Heike

doi:10.1016/j.ejpb.2013.11.010

Cited by 43 publications

(29 citation statements)

References 42 publications

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“…Bunjes et al prepared nanoemulsions by PME with droplet size lower or around 200 nm with narrow size distribution with polymeric membranes and SPG membranes for volumes up to 10 mL. [10,14,15]. In a previous work, we reported the production of O/W nanoemulsions by PME and SPG membranes at high flowrate and relatively large volumes up to 500 mL [16].…”

Section: Introductionmentioning

confidence: 87%

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Influence of viscosity for oil-in-water and water-in-oil nanoemulsions production by SPG premix membrane emulsification

Alliod

Messager

Fessi

et al. 2019

Chemical Engineering Research and Design

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Oil-in-water and water-in-oil nanoemulsions are interesting carriers for respectively oil soluble and water soluble actives. In this study, oil-in-water (O/W) and water-in-oil (W/O) nanoemulsions were prepared by premix membrane emulsification. A coarse emulsion (premix) was injected thanks to a high pressure pump through a Shirasu Porous Glass (SPG) membrane with pore size of 0.5 µm in order to reduce and homogenize the droplet size. The effect of viscosities on the pressure and droplet size was investigated: the water phase viscosity by increasing glycerol concentration, the oil phase viscosity with mineral oils of different viscosities and the overall emulsion viscosity by increasing the dispersed phase content of the emulsion. The pressure required to break up the droplets inside the membrane pores ∆P dis did not depend on viscosities, while the pressures generated by the flows through the pipe ∆P pipe and the membrane ∆P f low were proportional to the viscosity of the overall emulsion. W/O nanoemulsions were more difficult to produce and to characterize but thanks to the original setup working at pressures up to 65 bar and high flowrates, W/O mineral oil nanoemulsions were produced with mean droplets size around 600 nm and flow rate of 50 mL/min.

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Section: Introductionmentioning

confidence: 87%

“…DME shows limitations at nano-scale to preserve the monodispersity and small size of the droplets. In addition, flowrates of the dispersed phase are very low [10] which may not be suitable for scale-up.…”

Section: Introductionmentioning

confidence: 99%

Influence of viscosity for oil-in-water and water-in-oil nanoemulsions production by SPG premix membrane emulsification

Alliod

Messager

Fessi

et al. 2019

Chemical Engineering Research and Design

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“…For the production of nanoemulsions, PME is of great interest. Bunjes et al prepared nanoemulsions by PME with droplet sizes lower or around 200 nm with a narrow size distribution [18,19,20]). This result was explained by the high pore tortuosity and thickness of the Shirasu Porous Glass (SPG) membranes which are the most commonly used membranes for emulsification.…”

Section: Introductionmentioning

confidence: 99%

“…Using these SPG membranes and PME, Bunjes and Joseph produced a few milliliters of nanoemulsion [18,19,21]. The production of nanoemulsions by membrane emulsification remains a challenging undertaking [18] especially for large volumes at high flowrates.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Three Processes for Parenteral Nanoemulsion Production: Ultrasounds, Microfluidizer, and Premix Membrane Emulsification

Alliod

Almouazen

Nemer

et al. 2019

Journal of Pharmaceutical Sciences

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Nanoemulsions are of great interest for pharmaceutical applications, including parenteral dosage forms. However, their production is still limited and requires more efficient and adaptive technologies. The more common systems are high-shear homogenization like microfludizers (MF) at industrial scale and ultrasounds at research scale, both based on high energy limiting their application for sensitive drugs. Recently, a process based on premix membrane emulsification (PME) was developed to produce nanoemulsions. These three processes have been compared for the production of a model parenteral nanoemulsion containing all-transretinoic acid, a thermolabile molecule which is used in the treatment of acute promyelocytic leukemia in a parenteral form. Droplet size and active integrity were studied because of their major interest for efficacy and safety assessment. Regarding droplet size, PME produced monodispersed droplets of 335 nm compared to the other processes which produced nanoemulsions of around 150 nm but with the presence of micron size droplets detected by laser diffraction and optical microscopy. No real difference between the three processes was observed on active degradation during emulsifcation. However, regarding stability, especially at 40 o C nanoemulsions obtained with the microfluidizer showed a greater molecule degradation and unstable nanoemulsion with a 4 times droplet size increase under stress conditions.

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“…This is certainly the case when using miniemulsions generated by ultrasonication for such templating purposes—aside from the economical aspect, such high energy input may not be suitable when sensitive substances are being encapsulated, as they may lose their functional properties . For example, ultrasonication can induce heating phenomena as well as radical formation, which may lead to oxidation of sensitive materials . This may limit the range of substances that can be encapsulated within polydopamine capsules by miniemulsion templating.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of polydopamine capsules via SPG membrane emulsion templating: Tuning of capsule size

Zhai

Ishizuka

Stenzel

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

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Monodisperse polydopamine capsules with thin shells are synthesized by dopamine polymerization using toluene emulsion droplets as templates. Aqueous emulsions of monodisperse toluene droplets stabilized by the anionic surfactant sodium dodecyl sulfate are prepared by use of Shirasu porous glass membrane emulsification. This approach allows convenient tuning of the polydopamine capsule size via the membrane emulsification pore size, as exemplified by providing access to well‐defined capsules with diameters in the submicron – micron‐size range.

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Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions

Cited by 43 publications

References 42 publications

Influence of viscosity for oil-in-water and water-in-oil nanoemulsions production by SPG premix membrane emulsification

Influence of viscosity for oil-in-water and water-in-oil nanoemulsions production by SPG premix membrane emulsification

Comparison of Three Processes for Parenteral Nanoemulsion Production: Ultrasounds, Microfluidizer, and Premix Membrane Emulsification

Synthesis of polydopamine capsules via SPG membrane emulsion templating: Tuning of capsule size

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