The September 6, 2018, earthquake in the eastern part of Hokkaido, Japan, caused extensive slope failures in Atsuma-town, Hokkaido, Japan. In this study, the authors performed in situ investigations, including trenching and portable dynamic cone penetration tests, on weathered fallen pumice sediments, which are one of the causes of the slope failures. In addition, we performed direct box shear tests on undisturbed samples collected from an undisturbed area under various shear conditions to characterize mechanical properties of the soil. The parameters obtained from the mechanical tests were used to evaluate slope stability under normal and seismic conditions with an infinite-length slope model. The results showed that the slopes where seismic failures occurred had a fragile layer from the surface to a depth of approximately 1.5 m, which generally corresponded to the depth of failure. Weathered pumice deposits with extremely high-water content existed at the boundary between the weak layer and the basement layer, and their shear strength was velocity dependent. It has been shown that an infinite-length slope stability analysis can be performed by using mechanical parameters for which velocity dependence of horizontal acceleration and shear strength due to seismic motion are accounted for.