Evaluation of sialic acid, malondialdehyde and glutathione levels in infertile male

Menevşe, Esma; Dursunoğlu, Duygu; Cetin, Nihal; Korucu, Emine Nedime; Erbayram, Fatma Zehra

doi:10.1016/j.androl.2021.05.002

Cited by 2 publications

(1 citation statement)

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“…At the same time, it has been found that infertile subjects lack sialylation in seminal samples [252], and sialylation as a biochemical indicator has moderate clinical value in infertile male patients [49]. Sialylation can be used as one of the biological markers of oligozoospermia [253][254][255]. Currently, sialic acid levels are commonly used as one of the indicators to evaluate male fertility in a large number of animal experiments [256][257][258][259][260][261][262].…”

Section: Sialylation and Male Infertilitymentioning

confidence: 99%

Sialylation: fate decision of mammalian sperm development, fertilization, and male fertility

Feng

Wang

et al. 2023

Biology of Reproduction

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Sperm development, maturation, and successful fertilization within the female reproductive tract are intricate and orderly processes that involve protein translation and post-translational modifications. Among these modifications, sialylation plays a crucial role. Any disruptions occurring throughout the sperm’s life cycle can result in male infertility, yet our current understanding of this process remains limited. Conventional semen analysis often fails to diagnose some infertility cases associated with sperm sialylation, emphasizing the need to comprehend and investigate the characteristics of sperm sialylation. This review re-analyzes the significance of sialylation in sperm development and fertilization, and evaluates the impact of sialylation damage on male fertility under pathological conditions. Sialylation serves a vital role in the life journey of sperm, providing negatively charged glycocalyx and enriching the molecular structure of the sperm surface, which is beneficial to sperm reversible recognition and immune interaction. These characteristics are particularly crucial during sperm maturation and fertilization within the female reproductive tract. Moreover, enhancing the understanding of the mechanism underlying sperm sialylation can promote the development of relevant clinical indicators for infertility detection and treatment.

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