Evaluation of sickle cell aggregation by ultrasound backscattering

Quantitative Measurement of Erythrocyte Aggregation as a Systemic Inflammatory Marker by Ultrasound Imaging: A Systematic Review

“…Ultrasound imaging is the other promising approach for measuring erythrocyte aggregation. Though research on ultrasound for measuring erythrocyte aggregation has a long history (Boynard et al 1987(Boynard et al , 1988Shung 1988a, 1988b), these methods have not been widely accepted by hemorheologists and the clinical community in general, probably because of the complexity of acoustic modelling, quantitative approaches, data analyses, and the subjective nature of the image interpretation (i.e., the lack of physical interpretability of reported data). Several attempts have been made to provide interpretable physical indices of erythrocyte aggregation to the scientific community and clinicians (Fontaine et al 1999(Fontaine et al , 2002Franceschini et al 2008Franceschini et al , 2010Recchia and Wickline 1993;Sennaoui et al 1997;Yu and Cloutier 2007).…”