Evaluation of silver and copper oxide NANOPARTICLES release from different prosthetic materials incorporated with nanoparticles

Abstract

The purpose of this study was to evaluate the amount of released of silver and copper oxide nanoparticles when they were incorporated in heat cured acrylic resin denture, chemical cured soft liner, and cream type adhesive. Material and methods:A total number of 240 samples were prepared, 80 denture base samples, 80 liner, and 80 adhesives, and 10 samples from each material were free from nanoparticles that act as a control. The remaining samples were divided into two groups: (Group I) contained denture base, liner and adhesive samples modified with copper-oxide nanoparticles concentration by (0.1%, 0.3%, and 0.5%, 10 sample each), and (Group II) has the same number of samples but modified with same silver nanoparticles concentrations. The samples were placed in distilled water for one week and the amount of release was measured by spectrophotometer. The recordings data were analyzed using Two-way repeated measures Analysis of Variance (ANOVA) to compare between the three groups as well as to study the effect of time within each group. Bonferroni's post-hoc test was used for pair-wise comparisons. P< 0.05 was considered.Results: Release was higher in denture adhesive followed by denture liner and denture base respectively in the two groups. The amount of release increased with increasing nanoparticles concentration in denture base and adhesive but not in denture liner. There was no significant difference between Group I, and Group II. Conclusion:Nanoparticle release was affected by the type of prosthetic material, nanoparticle concentration, but not nanoparticles type.

Correlation between the water sorption and the flexural strength in heat-cured acrylic resin with different fillers

“…Second: there are a few studies regarding the toxicity, safety, whether the amount of leaching of nanoparticles from acrylic at the concentrations in this study is less than the toxic level or not. However, the amount of nanoparticles release from the denture base is less than the denture liner and the denture adhesive irrespective of the type of nanoparticle (33) . Third: the medium in this study didn't stimulate oral fluid conditions.…”

One-year clinical investigation of the effect of inclusion of three nanoparticles in the heat-cured acrylic resin denture base on the adhesion with the silicone soft-liner

“…Nanoparticles were added to the denture base because it had lower values of nanoparticle release. A comparative study of nanoparticle release from denture base, liner, and adhesive showed that the release was higher in the denture adhesive followed by liner and denture base (32) . Increase release of the nanoparticle may cause systemic toxicity, especially to the CNS (33) .…”

Application of Copper Nanoparticles in Dentistry

“…However, the release of these ions may vary. A study showed that the denture base and adhesive had higher releases compared with the denture liner [ 80 ]. Researchers may explore the controlled and optimum therapeutic release of copper ions for an optimum clinical outcome.…”