Evaluation of simple inflammatory blood parameters in patients with migraine

Yazar, Hülya Olgun; Yazar, Tamer; Aygün, Ali; Kaygısız, Şükran; Kırbaş, Dursun

doi:10.1007/s11845-019-02136-y

Cited by 37 publications

(33 citation statements)

References 47 publications

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“…The principal findings of the present study were that CAR, NAR, NLR, PLR, MLR, RDW, and MPV were peripheral inflammatory markers that were increased in a relatively large sample of patients with schizophrenia compared with healthy controls. Despite CAR values having been recently reported in patients with Parkinson disease, 19 restless leg syndrome, 18 and migraine, 17 this is the first study to examine CAR and NAR in patients with with schizophrenia.…”

Section: Discussionmentioning

confidence: 88%

“…15,16 Previously, CAR has been studied in several neurological illnesses including Parkinson's disease, migraine, and restless leg syndrome, and these studies have suggested that CAR might reflect increased inflammatory status in such neurological conditions. [17][18][19] In a recent study, the association between depression severity and CAR has been examined in patients diagnosed lung cancer. 20 However, to date, CAR has not been studied in schizophrenia or other psychotic disorders.…”

Section: Introductionmentioning

confidence: 99%

“…CAR has been proposed to reflect enhanced inflammatory tonus and increased levels of this biomarker are suggestive for poor prognosis and worse treatment outcomes in patients with systemic illnesses [ 15 , 16 ]. Previously, CAR has been studied in several neurological illnesses including Parkinson’s disease, migraine, and restless leg syndrome, and these studies have suggested that CAR might reflect increased inflammatory status in such neurological conditions [ 17 - 19 ]. In a recent study, the association between depression severity and CAR has been examined in patients diagnosed lung cancer [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia

Balcıoğlu

Kırlıoğlu

2020

Psychiatry Investig

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Objective Peripheral biomarker studies in schizophrenia are insufficient to correspond to whether inflammatory markers are trait- or state-related. The main objective of this study was to compare novel biomarkers C-reactive protein/albumin ratio (CAR), neutrophil/albumin ratio (NAR), and complete blood count-derived inflammatory markers; neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), red-cell distribution width (RDW), and mean platelet volume (MPV) between patients with acutely exacerbated and remitted schizophrenia and healthy controls.Methods Anonymous data of a total of 618 patients with schizophrenia (179 in remission, 439 with acute exacerbation) and 445 psychiatrically and medically healthy subjects admitted to outpatient units were included. One-way ANOVA with Tukey’s HSD post-hoc test, Pearson’s correlation test, receiver operating characteristic analysis, and binomial logistic regression analysis were performed.Results CAR, NAR, NLR, PLR, MLR, RDW, MPV values were found higher in patients with schizophrenia than in healthy subjects. Except for NAR (p=0.007), none of the markers differed between acute exacerbation and remission. As a cut-off value of CAR, 0.388 differentiated patients with schizophrenia from controls (sensitivity 81%, specificity 81%). CAR, NAR, and MPV significantly predicted the diagnosis of schizophrenia.Conclusion CAR and NAR are reliable biomarkers of inflammation and a combination of inflammatory markers including CAR and NAR could be used to reflect the increased inflammatory status in schizophrenia, regardless of relapse or remission.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia

Balcıoğlu

Kırlıoğlu

2020

Psychiatry Investig

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“…Episodic and chronic migraine various inflammatory biomarkers and migraines have been investigated by several researchers [3,19,20]. Many researchers have investigated the relationships between the features of headaches and inflammation using hematologic parameters [3,6,10,13,[21][22][23]. The main goal of these studies is to evaluate the inflammatory processes using hematological markers and to investigate the association of these markers with clinical parameters of headaches, and their utility in discriminating headache syndromes from other diseases [10,24].…”

Section: The Results Of the Comparisons Of Nlr Between The Patient Grmentioning

confidence: 99%

May Neutrophil to Lymphocyte Ratio Serve a Role in the Prediction of Clinical Features of Migraine?

Önder

Deliktas

2020

J Neurol Res

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Background: We aimed to investigate the possible association between the value of neutrophil to lymphocyte ratio (NLR) and some specific features of migraine. Methods:We have included initially all the patients with migraine who applied to our neurology clinic in Yozgat City Hospital during December 2019 and agreed to participate in this study. The demographic and clinical characteristics including migraine subtype (episodic/chronic), headache frequency per month, headache characteristics of all patients were interrogated. Besides, the presence of fibromyalgia (FM) and chronic fatigue syndrome (CFS) was also noted. The severity of migraine was assessed using the headache impact test (HIT-6) and the severity of chronic fatigue was assessed using the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scale. A hemogram was performed upon admission to the clinic. The patients with migraine attacks during the clinic visits were excluded from the study.Results: Ultimately, 52 migraineurs were included in this study. The mean age was 37.34 ± 11.80 and the female/male (F/M) ratio was 49/3. Thirty-six patients (69%) were diagnosed with episodic migraine (EM), and 16 of them (31%) were diagnosed with chronic migraine (CM). The results of the comparative analyses between EM and CM groups showed that the NLR did not differ between groups. To evaluate the possible association of the NLR with other clinical parameters, additional comparative analyses evaluating the presence of FM, CFS, cognitive symptoms and tinnitus were also conducted, which showed no significant differences. The results of the correlation analyses to evaluate the possible associations between the NLR value and other clinical parameters were also unremarkable. Conclusions:We suggest that the NLR cannot be a specific marker to be used in the differential diagnosis or prediction of any features of migraines during the interictal period. However, in light of the previous reports, the utility of this value in the differentiating of migraine attacks from other causes of headache attacks can be investigated in future related studies.

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“…Recently, CAR, which is a marker for systemic inflammation, has been investigated as an independent prognostic marker in patients with infectious and other diseases (26). Similar to NLR, CAR has previously been shown to be high in migraine patients and it has been emphasized that peripheral inflammation may play a role in migraine pathogenesis (27). Similarly in our study, CRP and CAR were significantly higher in the COVID-19 patients with headache than those without headache, and according to our results, inflammation may play a role in the pathogenesis of headache in COVID-19.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Hastalarında Başağrısının Enflamatuvar Serum Parametreleri ve Hastalık Şiddeti ile İlişkisi

Bilge

Can

Alay

2020

Düzce Tıp Fakültesi Dergisi

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Aim: Most of the coronavirus disease 2019 (COVID-19) patients have respiratory symptoms; however, various neurological symptoms, such as headache, can be seen. The pathophysiological mechanism of headache in COVID-19 is unknown completely. In our study, we aimed to investigate the relationship between headache and inflammatory markers and disease severity in COVID-19 patients. Material and Methods: Two hundred and three hospitalized patients with a polymerase chain reaction (PCR)-confirmed COVID-19 diagnosis between 15 March and 01 June 2020 were retrospectively investigated. A total of 62 patients with headache symptoms (n=31) and without headache symptoms (n=31), who were age and gender-matched, were included in the study. The demographic characteristics, inflammatory serum parameters, neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP)/albumin ratio (CAR), hospitalization times, and disease severity were determined. Results: Of the 203 COVID-19 patients, 36 (17.7%) had a headache, and it was the fourth most common symptom. Headache accompanied other symptoms in all patients. Of the patients with headache, 14 (45.2%) were female, 17 (54.8%) were male, and the mean age was 37.74±16.65 years. In our COVID-19 patients, the neutrophil count, NLR, CRP, CAR were significantly higher, and hospital stay was longer in patients with headache than those without headache (p=0.023, p=0.041, p=0.034, p=0,048 and p=0.049, respectively). Conclusion: As a result, the increased inflammatory response may play a role in the pathogenesis of headache in COVID-19 patients. Our study is the first study that evaluated the relationship between headache symptom and inflammation in COVID-19 patients. Further research is needed on this subject.

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Evaluation of simple inflammatory blood parameters in patients with migraine

Cited by 37 publications

References 47 publications

C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia

C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia

May Neutrophil to Lymphocyte Ratio Serve a Role in the Prediction of Clinical Features of Migraine?

COVID-19 Hastalarında Başağrısının Enflamatuvar Serum Parametreleri ve Hastalık Şiddeti ile İlişkisi

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