Evaluation of six candidate genes for dilated cardiomyopathy in Irish wolfhounds

Philipp, Ute; Vollmar, Andrea; Distl, O.

doi:10.1111/j.1365-2052.2007.01684.x

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…Philipp et al [23] used a total of 190 individuals, and in the present study 379 DNA samples were collected but following more stringent inclusion criteria 95 individuals could be included in the genetic association analysis. The age an individual can be considered healthy for DCM genetic association purposes varies between breeds, but it has not previously been based on clear justification [23, 28, 39]. The analysis in the present study shows the age that an unaffected male can be included in the healthy group was younger than an unaffected female (Figure 2).…”

Section: Discussionmentioning

confidence: 52%

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Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy

Simpson

Dunning

Brownlie

et al. 2016

BioMed Research International

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Cardiac disease is a leading cause of morbidity and mortality in dogs and humans, with dilated cardiomyopathy being a large contributor to this. The Irish Wolfhound (IWH) is one of the most commonly affected breeds and one of the few breeds with genetic loci associated with the disease. Mutations in more than 50 genes are associated with human dilated cardiomyopathy (DCM), yet very few are also associated with canine DCM. Furthermore, none of the identified canine loci explain many cases of the disease and previous work has indicated that genotypes at multiple loci may act together to influence disease development. In this study, loci previously associated with DCM in IWH were tested for associations in a new cohort both individually and in combination. We have identified loci significantly associated with the disease individually, but no genotypes individually or in pairs conferred a significantly greater risk of developing DCM than the population risk. However combining three loci together did result in the identification of a genotype which conferred a greater risk of disease than the overall population risk. This study suggests multiple rather than individual genetic factors, cooperating to influence DCM risk in IWH.

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Section: Discussionmentioning

confidence: 52%

“…Previous IWH DCM genetic association studies have either not reported the age of their unaffected IWHs or used arbitrary ages to define the unaffected control group [23, 28, 39]. Brownlie and Cobb [32] found a difference between the sexes in the age of onset of DCM in IWH in 39 individuals.…”

Section: Introductionmentioning

confidence: 99%

Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy

Simpson

Dunning

Brownlie

et al. 2016

BioMed Research International

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“…Another 6 genes (cardiac muscle actin alpha, cysteine and glycine-rich protein 3, desmin, phospholamban, sarcoglycan delta, and tropomodulin 1) were eliminated as candidates for association with DCM in Irish Wolfhounds by Philipp et al (2007b). The same authors also showed that the tafazzin (TAZ) gene has no influence on the development of DCM in this breed (Philipp et al, 2007a).…”

Section: Human Genetic Markers Of Heart Disease In Dogsmentioning

confidence: 84%

Genomic and genetic aspects of heart failure in dogs — A review

Łój

Garncarz

Jank

2012

Acta Veterinaria Hungarica

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The most common causes of heart failure in dogs are valvular disease, predominantly endocardiosis, and myocardial disease, predominantly dilated cardiomyopathy. They are related to changes in the expression of several genes in the heart muscle and in peripheral blood nuclear cells which could be considered as prognostic or diagnostic markers of heart disease in dogs. Since many human genetic markers of heart failure have turned out to be useless in dogs, the screening for genomic markers of canine heart failure could give more insight into the molecular pathology of these diseases and aid the development of new treatment strategies.

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“…Le mode de transmission monogénique de la maladie a été rejeté (Distl et al 2007). L'évaluation de plusieurs gènes candidats, incluant la tafazzine situé sur le chromosome sexuel X, n'a pas permis jusqu'à maintenant de trouver des mutations impliquées dans la maladie (Philipp, 2007a(Philipp, , 2007b. La recherche d'association génétique sur une population non apparentée de malades et de témoins a alors été réalisée dans le cadre du projet LUPA.…”

Section: éTude De La Cmd Chez Le Lévrier Irlandaisunclassified

La cardiomyopathie dilatée du chien : résultats de l’étude européenne LUPA

Thomas¹

2013

bavf

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Plusieurs races de chiens sont prédisposées à la cardiomyopathie dilatée. Certaines, comme le Lévrier Irlandais, le Dobermann ou encore le Boxer, sont bien documentées sur le plan clinique. Dans le cadre du projet européen LUPA, ces races ont fait l'objet d'études génétiques afin de rechercher les bases moléculaires associées à cette maladie. Plusieurs régions génomiques d'intérêt ont été cernées. Dans le même temps, deux mutations ont été décrites pour deux races distinctes aux Etats-Unis. Leur pertinence diffère selon l'appartenance géographique des populations testées. Cet article a pour objet de présenter l'avancée des connaissances génétiques dans le domaine de la cardiomyopathie dilatée canine obtenues grâce au projet LUPA. Mots-clés : chien, cardiomyopathie dilatée, génétique, mutation, modèle animal. RÉSUMÉDilated cardiomyopathy is a common disease in several canine large breeds. The clinical characteristics are very well described for some breeds like the Irish Wolfhound, the Doberman pinscher or the Boxer. In the frame of the European project LUPA, genetic studies were lead on these breeds to determine the molecular basis of the disease. Several genomic areas were highlighted. During the project, two mutations were described for two different canine breeds in the United States. According to the geographical origin of the population, the relevance of the mutations varies. This article presents the results of the LUPA project on genetic knowledge in dilated cardiomyopathy.

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Evaluation of six candidate genes for dilated cardiomyopathy in Irish wolfhounds

Cited by 9 publications

References 6 publications

Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy

Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy

Genomic and genetic aspects of heart failure in dogs — A review

La cardiomyopathie dilatée du chien : résultats de l’étude européenne LUPA

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