Evaluation of skin sympathetic nervous activity for classification of intracerebral hemorrhage and outcome prediction

Xing, Yantao; Cheng, Hongyi; Yang, Chenxi; Xiao, Zhijun; Yan, Chang; Chen, FeiFei; Li, Jiayi; Zhang, Yike; Cui, Chang; Li, Jianqing; Liu, Chengyu

doi:10.1016/j.compbiomed.2023.107397

Cited by 3 publications

(5 citation statements)

References 49 publications

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“…The burst amplitude is correlated to both skin blood flow reduction rate and sweat rate change. As a non‐invasive sympathetic activity assessment method, SSNA has been widely used to predict sympathetic tone in cardiac diseases, neurological disorders, sleep apnea, etc 112–116 . The ICH classification and outcome prediction based on the SSNA signal had been proved to be a feasible method 114 .…”

Section: Assessmentmentioning

confidence: 99%

“…Skin sympathetic nerve activity (SSNA) is microneurographically recorded from the skin nerve fascicle in the peripheral nerves, which is characterized by burst activity followed by vasoconstriction and/or sweating, and usually elicited by mental stress and arousal stimulation. 112 , 113 , 114 It comprises vasoconstrictor (VC), sudomotor (SM) activity, and vasodilator (VD) activity. The burst amplitude is correlated to both skin blood flow reduction rate and sweat rate change.…”

Section: Assessmentmentioning

confidence: 99%

“…As a non‐invasive sympathetic activity assessment method, SSNA has been widely used to predict sympathetic tone in cardiac diseases, neurological disorders, sleep apnea, etc. 112 , 113 , 114 , 115 , 116 The ICH classification and outcome prediction based on the SSNA signal had been proved to be a feasible method. 114 Sympathetic skin response (SSR) is also a kind of epidermal potential that is related to sweat gland activity and reflects the function of sympathetic nervous system.…”

Section: Assessmentmentioning

confidence: 99%

“… 112 , 113 , 114 , 115 , 116 The ICH classification and outcome prediction based on the SSNA signal had been proved to be a feasible method. 114 Sympathetic skin response (SSR) is also a kind of epidermal potential that is related to sweat gland activity and reflects the function of sympathetic nervous system. 117 , 118 …”

Section: Assessmentmentioning

confidence: 99%

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Autonomic dysfunction and treatment strategies in intracerebral hemorrhage

Kang,

Shi,

Liu

et al. 2024

CNS Neurosci Ther

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AimsAutonomic dysfunction with central autonomic network (CAN) damage occurs frequently after intracerebral hemorrhage (ICH) and contributes to a series of adverse outcomes. This review aims to provide insight and convenience for future clinical practice and research on autonomic dysfunction in ICH patients.DiscussionWe summarize the autonomic dysfunction in ICH from the aspects of potential mechanisms, clinical significance, assessment, and treatment strategies. The CAN structures mainly include insular cortex, anterior cingulate cortex, amygdala, hypothalamus, nucleus of the solitary tract, ventrolateral medulla, dorsal motor nucleus of the vagus, nucleus ambiguus, parabrachial nucleus, and periaqueductal gray. Autonomic dysfunction after ICH is closely associated with neurological functional outcomes, cardiac complications, blood pressure fluctuation, immunosuppression and infection, thermoregulatory dysfunction, hyperglycemia, digestive dysfunction, and urogenital disturbances. Heart rate variability, baroreflex sensitivity, skin sympathetic nerve activity, sympathetic skin response, and plasma catecholamine concentration can be used to assess the autonomic functional activities after ICH. Risk stratification of patients according to autonomic functional activities, and development of intervention approaches based on the restoration of sympathetic‐parasympathetic balance, would potentially improve clinical outcomes in ICH patients.ConclusionThe review systematically summarizes the evidence of autonomic dysfunction and its association with clinical outcomes in ICH patients, proposing that targeting autonomic dysfunction could be potentially investigated to improve the clinical outcomes.

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Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Autonomic dysfunction and treatment strategies in intracerebral hemorrhage

Kang,

Shi,

Liu

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…The measurement of neurotransmitters, particularly catecholamines circulating in the blood can also serve as a diagnostic tool for evaluating the autonomic nervous system ( Zygmunt and Stanczyk, 2004 ). Recent studies have employed the usage of electrocardiogram (ECG) and skin sympathetic activity for predicting the outcome of intracerebral hemorrhage ( Xing et al, 2023 ). Microneurography is yet another emerging diagnostic tool in which separate recordings of sympathetic nerve activity to the muscles (reflects the vasoconstrictor signal to the muscle) and sympathetic nerve activity to the skin vessels are employed.…”

Section: Introductionmentioning

confidence: 99%

Clinical potential of sensory neurites in the heart and their role in decision-making

Tendulkar,

Dhanda

et al. 2024

Front. Neurosci.

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The process of decision-making is quite complex involving different aspects of logic, emotion, and intuition. The process of decision-making can be summarized as choosing the best alternative among a given plethora of options in order to achieve the desired outcome. This requires establishing numerous neural networks between various factors associated with the decision and creation of possible combinations and speculating their possible outcomes. In a nutshell, it is a highly coordinated process consuming the majority of the brain’s energy. It has been found that the heart comprises an intrinsic neural system that contributes not only to the decision-making process but also the short-term and long-term memory. There are approximately 40,000 cells present in the heart known as sensory neurites which play a vital role in memory transfer. The heart is quite a mysterious organ, which functions as a blood-pumping machine and an endocrine gland, as well as possesses a nervous system. There are multiple factors that affect this heart ecosystem, and they directly affect our decision-making capabilities. These interlinked relationships hint toward the sensory neurites which modulate cognition and mood regulation. This review article aims to provide deeper insights into the various roles played by sensory neurites in decision-making and other cognitive functions. The article highlights the pivotal role of sensory neurites in the numerous brain functions, and it also meticulously discusses the mechanisms through which they modulate their effects.

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Sensors and Devices Guided by Artificial Intelligence for Personalized Pain Medicine

Xing,

Yang,

et al. 2024

Cyborg Bionic Syst

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Personalized pain medicine aims to tailor pain treatment strategies for the specific needs and characteristics of an individual patient, holding the potential for improving treatment outcomes, reducing side effects, and enhancing patient satisfaction. Despite existing pain markers and treatments, challenges remain in understanding, detecting, and treating complex pain conditions. Here, we review recent engineering efforts in developing various sensors and devices for addressing challenges in the personalized treatment of pain. We summarize the basics of pain pathology and introduce various sensors and devices for pain monitoring, assessment, and relief. We also discuss advancements taking advantage of rapidly developing medical artificial intelligence (AI), such as AI-based analgesia devices, wearable sensors, and healthcare systems. We believe that these innovative technologies may lead to more precise and responsive personalized medicine, greatly improved patient quality of life, increased efficiency of medical systems, and reducing the incidence of addiction and substance use disorders.

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Evaluation of skin sympathetic nervous activity for classification of intracerebral hemorrhage and outcome prediction

Cited by 3 publications

References 49 publications

Autonomic dysfunction and treatment strategies in intracerebral hemorrhage

Autonomic dysfunction and treatment strategies in intracerebral hemorrhage

Clinical potential of sensory neurites in the heart and their role in decision-making

Sensors and Devices Guided by Artificial Intelligence for Personalized Pain Medicine

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