Evaluation of skin test reactivity to environmental allergens in healthy cats and cats with atopic dermatitis

Schleifer, Sebastian G.; Willemse, Ton

doi:10.2460/ajvr.2003.64.773

Cited by 30 publications

(42 citation statements)

References 28 publications

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“…It was recently reported that the irritancy thresholds for IDT allergens in cats may need to be changed and that many ‘positive allergen reactions’ may in fact be due to irritant reactions 18 . However, in another study, no evidence of irritancy was found 19 . In the study reported here, if the positive reactions were caused by irritancy, it seems reasonable that a similar proportion of normal cats would have had false‐positive allergen reactions, but this was not the case.…”

Section: Discussionmentioning

confidence: 98%

Pilot study: prevalence of positive aeroallergen reactions in 10 cats with small‐airway disease without concurrent skin disease

Moriello

Stepien

Henik

et al. 2007

Veterinary Dermatology

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The purpose of this study was to determine the prevalence of positive allergen reactions in cats with small-airway disease (i.e. 'feline asthma', 'feline allergic bronchitis', 'feline bronchial disease'). Intradermal skin tests (IDT) and serum immunoglobulin E (IgE) tests were performed in 10 cats with idiopathic small-airway disease and in 10 normal cats without a history of respiratory disease. None of the cats had a history of skin disease or clinical signs of skin disease at the time of testing. Significantly more individual positive allergen reactions were found on serum IgE tests than on IDT in both groups of cats. Affected cats had significantly more individual positive allergen reactions on both tests than unaffected cats. Both IDT and serum IgE tests resulted in more individual positive allergen reactions to weeds, trees, grasses, and/or moulds in affected cats than in normal cats. Significantly more positive allergen reactions to house dust mites were found in affected compared to non-affected cats by IDT but not by serum IgE testing. One unexpected obstacle to inclusion of more affected cats in the study was the concurrent presence or history of suspect or known allergic skin disease. Concurrent allergic skin disease has not been reported in association with small-airway disease in cats. The increased prevalence of individual positive allergen reactions in affected cats may be due to increased immunological reactivity in these cats. Further studies are needed to answer this question and to determine what role, if any, aeroallergens have in the pathogenesis of this complex feline disease.

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Section: Discussionmentioning

confidence: 98%

Pilot study: prevalence of positive aeroallergen reactions in 10 cats with small‐airway disease without concurrent skin disease

Moriello

Stepien

Henik

et al. 2007

Veterinary Dermatology

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“…Among the animals of atopic dermatitis, the mouse, guinea pig (Fukuda et al, 2003), cat (Schleifer and Willemse, 2003), dog (Mueller et al, 2004) and horse (Lorch et al, 2001) are used. Mouse model of atopic dermatitis gets wider acceptance.…”

Section: Discussionmentioning

confidence: 99%

Mouse model of DNCB-induced atopic dermatitis

Hamad

Han

Rather

2017

Bangladesh J Pharmacol

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Atopic dermatitis is a skin disease characterized by allergic skin inflammation, redness and itching. The animal model is necessary to find out new drugs. The DNCB-induced animal model of atopic dermatitis includes the following steps: 1) Selection of animals; 2) Shaving of dorsal skin; 3) Applying DNCB once in 24 hours for three days; 4) Monitoring the development of atopy on day 4 post DNCB application. Further, the efficacy of reference drug can be determined by applying on the atopy skin, depends on the nature and aim of the work.

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“…Different species including mice, dogs, cats and horses have been reported to develop AE-like skin lesions [13, 14, 15]. AE-like symptoms in dogs, cats or horses are diseases present in these domestic companions and are treated as disease states by veterinarians.…”

Section: Mouse Models Of Aementioning

confidence: 99%

Mouse Models of Atopic Eczema Critically Evaluated

Gutermuth¹,

Ollert

Ring³

et al. 2004

Int Arch Allergy Immunol

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Atopic eczema (AE) is a chronic relapsing inflammatory skin disorder with increasing prevalence in Western societies. Even though we have made considerable progress in understanding the cellular and molecular nature of cutaneous inflammation, the precise pathomechanisms of AE still remain elusive. Experimental animal models are indispensable tools to study the pathogenic mechanisms and to test novel therapeutic approaches in vivo. For AE a considerable number of mouse models have been proposed and have been used to study specific aspects of the disease, such as genetics, skin barrier defects, immune deviations, bacteria–host interactions or the role of cytokines or chemokines in the inflammatory process. While some models closely resemble human AE, others appear to reflect only specific aspects of the disease. Here we review the currently available mouse models of AE in light of the novel World Allergy Organization classification of eczematous skin diseases and evaluate them according to their clinical, histopathological and immunological findings. The pathogenetic analogies between mice and men will be discussed.

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Evaluation of skin test reactivity to environmental allergens in healthy cats and cats with atopic dermatitis

Abstract: Skin test reactivity in cats should be evaluated after IV administration of 10% fluorescein solution by means of a Prausnitz-Küstner test to differentiate among IgE-mediated, IgG-mediated, and nonspecific reactions.

Cited by 30 publications

References 28 publications

Pilot study: prevalence of positive aeroallergen reactions in 10 cats with small‐airway disease without concurrent skin disease

Pilot study: prevalence of positive aeroallergen reactions in 10 cats with small‐airway disease without concurrent skin disease

Mouse model of DNCB-induced atopic dermatitis

Mouse Models of Atopic Eczema Critically Evaluated

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