Evaluation of Skin Tumors by Magnetic Resonance Imaging

Rajeswari, Moganty R.; Jain, Aklank; Sharma, Ashok; Singh, Dinesh Kumar; Jagannathan, Naranamangalam R.; Sharma, Uma; Degaonkar, Mahaveer

doi:10.1097/01.lab.0000088767.45565.27

Cited by 18 publications

(10 citation statements)

References 17 publications

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“…However, the introduction of microscopy surface coils has enabled its use in the evaluation of more superficial structures with better image quality and high resolution (1). Numerous studies have shown the usefulness of high-resolution MRI with microscopy coils (HR-MRI) in the evaluation of patellar cartilage, soft tissue tumors of the hand and foot, and ocular lesions including ocular melanomas (2-4).…”

Section: Introductionmentioning

confidence: 99%

Accuracy of Preoperative MRI with Microscopy Coil in Evaluation of Primary Tumor Thickness of Malignant Melanoma of the Skin with Histopathologic Correlation

et al. 2013

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ObjectiveThe purpose of this study was to evaluate the accuracy of a preoperative MRI with microscopy coils in determining the primary tumor thickness of malignant melanoma with histopathologic correlation.Materials and MethodsEleven patients with histopathologically confirmed malignant melanoma were included in this study. MR images of the tumors were obtained with a 47-mm microscopy coil on 1.5T MR scanners and were evaluated by two radiologists, who assessed the thickness of the primary tumor on T2-weighted images (T2WI) and gadolinium-enhanced T1-weighted images with fat suppression (Gd-T1WI) and compared the results with the histopathologic findings as the reference standard. Correlations between tumor thickness on MRI and histopathologic examination were assessed using concordance correlation coefficients (CCCs). Inter- and intraobserver variabilities of tumor measurements were also assessed by intraclass correlation coefficient (ICC).ResultsAmong the 11 cases included in the study, 10 cases from the same number of patients were managed with surgical excision and one case was confirmed with punch biopsy. The primary tumor thickness measured on T2WI showed better correlation with histopathologic results, as compared with measurements taken on Gd-T1WI: the CCC of measurements on T2WI ranged from 0.64 to 0.78, indicating a substantial agreement, whereas the CCC of measurements on Gd-T1WI ranged from 0.50 to 0.61, indicating a moderate to substantial agreement. Inter- and intraobserver agreements of readers 1 and 2 were excellent for both T2WI and Gd-T1WI, with ICC ranging from 0.86 to 0.99.ConclusionMR imaging with microscopy coils may be an accurate technique in the preoperative assessment of tumor thickness in malignant melanoma, especially on T2-weighted images.

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Section: Introductionmentioning

confidence: 99%

Accuracy of Preoperative MRI with Microscopy Coil in Evaluation of Primary Tumor Thickness of Malignant Melanoma of the Skin with Histopathologic Correlation

et al. 2013

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“…Because such observation depends on personal experience of the physician, lesions may be falsely considered benign, may not undergo biopsy, and therefore may not be subjected to the reference diagnostic gold standard i.e. histo-pathology [2]. Currently, full diagnosis of suspicious skin lesions implies excision-biopsy of the lesion followed by anatomo-pathological examination.…”

Section: Introductionmentioning

confidence: 99%

Bimodal spectroscopic evaluation of ultra violet-irradiated mouse skin inflammatory and precancerous stages: instrumentation, spectral feature extraction/selection and classification (k-NN, LDA and SVM)

Díaz-Ayil

Amouroux

Blondel

et al. 2009

Eur. Phys. J. Appl. Phys.

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et al.. Bimodal spectroscopic evaluation of ultra violet-irradiated mouse skin inflammatory and precancerous stages: instrumentation, spectral feature extraction/selection and classification (k-NN, LDA and SVM).Abstract. This paper deals with the development and application of in vivo spatially-resolved bimodal spectroscopy (AutoFluorescence AF and Diffuse Reflectance DR), to discriminate various stages of skin precancer in a pre-clinical model (UV-irradiated mouse): Compensatory Hyperplasia CH, Atypical Hyperplasia AH and Dysplasia D. A programmable instrumentation was developed for acquiring AF emission spectra using 7 excitation wavelengths: 360, 368, 390, 400, 410, 420 and 430 nm, and DR spectra in the 390-720 nm wavelength range. After various steps of intensity spectra preprocessing (filtering, spectral correction and intensity normalization), several sets of spectral characteristics were extracted and selected based on their discrimination power statistically tested for every pair-wise comparison of histological classes. Data reduction with Principal Components Analysis (PCA) was performed and 3 classification methods were implemented (k-NN, LDA and SVM), in order to compare diagnostic performance of each method. Diagnostic performance was studied and assessed in terms of Sensibility (Se) and Specificity (Sp) as a function of the selected features, of the combinations of 3 different inter-fibres distances and of the numbers of principal components, such that: Se and Sp ≈ 100% when discriminating CH vs. others; Sp ≈ 100% and Se > 95% when discriminating Healthy vs. AH or D; Sp ≈ 74% and Se ≈ 63% for AH vs. D.

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“…For example, MRI of the skin surface requires an enlarged field of view and increased sensitivity, lending itself to potential inaccuracy in determination of the margins of the subcutaneous tissues, and possible inaccurate estimation of the depth from skin to epidural space. 19 …”

Section: Discussionmentioning

confidence: 99%

Assessing the Agreement Between Radiologic and Clinical Measurements of Lumbar and Cervical Epidural Depths in Patients Undergoing Prone Interlaminar Epidural Steroid Injection

Jones

Singh

Nidecker

et al. 2017

Anesthesia &Amp; Analgesia

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Background Fluoroscopy-guided epidural steroid injection (ESI) is commonly performed to treat radicular pain, yet can lead to adverse events if the needle is not advanced with precision.1, 2, 3 Accurate preoperative assessment of the distance from the skin to the epidural space holds the potential for reducing the risks of adverse effects from ESI. It was hypothesized that the distance from the skin to the epidural space as measured on preoperative magnetic resonance imaging (MRI) would agree with the distance traveled by a Touhy needle to reach the epidural space during midline, interlaminar ESI. This study compared the final needle depth measurement at the point of loss of resistance (LOR) from cervical or lumbar ESI to the distance from the skin to the anterior and posterior borders of the epidural space on the associated cervical and lumbar preoperative MRI. Methods This retrospective chart review analyzed the procedure notes, MRI, and demographic data of patients who received a prone, interlaminar ESI at an outpatient chronic pain clinic between June 1, 2013 and June 1, 2015. The following data were collected: BMI, age, gender, intervertebral level of the ESI, and LOR depth. We then measured the distance from the skin surface to the anterior border of the ligamentum flavum (ligamentum flavum depth, or LFD) and dura (dura depth, or DD) on MRI. A total of 335 patients were categorized into the following patient subgroups: age ≥ 65 years, age < 65 years, BMI ≥ 30 kg/m2 (obese), BMI < 30 kg/m2 (non-obese), male, and female. Secondary analyses were then performed to compare the agreement between LOR depth and DD with that between LOR depth and LFD within each patient subgroup. Intra-class correlation coefficient (ICC) and Bland-Altman plot were used to assess the agreement between DD or LFD and LOR depth. Results Data from 335 ESIs were analyzed, including 147 cervical ESIs and 188 lumbar ESIs. Estimated ICC values for the agreement between LOR depth and LFD for all lumbar and cervical measurements were 0.88 (95% CI 0.85 – 0.91) and 0.72 (95% CI 0.64 – 0.79), respectively. Estimated ICC values for the agreement between LOR depth and DD for all lumbar and cervical measurements were 0.86 (95% CI 0.82 – 0.89) and 0.69 (95% CI 0.60 – 0.77), respectively. Conclusions This study assessed the agreement between MRI-derived measurements of epidural depth and those determined clinically. MRI-derived measurements from the skin to the anterior border of the ligamentum flavum, which represents the most posterior aspect of the epidural space, revealed stronger agreement with LOR depths than did measurements to the dura, or the most anterior aspect of the epidural space. These results require further analysis and refinement before supporting clinical application.

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Evaluation of Skin Tumors by Magnetic Resonance Imaging

Cited by 18 publications

References 17 publications

Accuracy of Preoperative MRI with Microscopy Coil in Evaluation of Primary Tumor Thickness of Malignant Melanoma of the Skin with Histopathologic Correlation

Accuracy of Preoperative MRI with Microscopy Coil in Evaluation of Primary Tumor Thickness of Malignant Melanoma of the Skin with Histopathologic Correlation

Bimodal spectroscopic evaluation of ultra violet-irradiated mouse skin inflammatory and precancerous stages: instrumentation, spectral feature extraction/selection and classification (k-NN, LDA and SVM)

Assessing the Agreement Between Radiologic and Clinical Measurements of Lumbar and Cervical Epidural Depths in Patients Undergoing Prone Interlaminar Epidural Steroid Injection

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