Evaluation of sleep quality in spouses of people with epilepsy

Hamamcı, Mehmet; Hacımusalar, Yunus; Karaaslan, Özgül; İnan, Levent Ertuğrul

doi:10.1016/j.yebeh.2019.03.027

Cited by 10 publications

(11 citation statements)

References 35 publications

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“…Therefore, the changes observed inside the group of epileptic animals after surgery could be due to the intrinsic relationship between sleep and epilepsy [35,36] as well as to the impact of the sleep-wake cycle on the development of seizures. This is consistent with evidence found in human patients [37,38].…”

Section: Behavioural Neurologysupporting

confidence: 93%

Changes in Physiological and Pathological Behaviours Produced by Deep Microelectrode Implantation Surgery in Rats: A Temporal Analysis

Chiprés-Tinajero

Núñez-Ochoa

Medina‐Ceja

2020

Behavioural Neurology

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Physiological behaviours such as the sleep-wake cycle and exploratory behaviours are important parameters in intact and sham-operated animals and are usually thought to be unaffected by experimental protocols in which neurosurgery is performed. However, there is insufficient evidence in the literature on the behavioural and cognitive effects observed after deep microelectrode implantation surgery in animal models of neurological diseases. Similarly, in studies that utilize animal models of neurological diseases, the impact of surgery on the pathological phenomena being studied is often minimized. Based on these considerations, we performed a temporal analysis of the effects of deep microelectrode implantation surgery in the hippocampus of rats on quiet wakefulness, sleep, and exploratory activity and the pathological behaviours such as convulsive seizures according to the Racine scale. Male Wistar rats (210-300 g) were used and grouped in sham and epileptic animals. Single doses of pilocarpine hydrochloride (2.4 mg/2 μl; i.c.v.) were administered to the animals to generate spontaneous and recurrent seizures. Deep microelectrode implantation surgeries in both groups and analysis of Fast ripples were performed. Physiological and pathological behaviours were recorded through direct video monitoring of animals (24/7). Our principal findings showed that in epileptic animals, one of the main behaviours affected by surgery is sleep; as a consequence of this behavioural change, a decrease in exploratory activity was also found as well as the mean time spent daily in seizures of scale 4 and the number of seizure events of scales 4 and 5 was increased after surgery. No significant correlations between the occurrence of FR and seizure events of scale 4 (rho 0.63, p value 0.25) or 5 (rho -0.7, p value 0.18) were observed. In conclusion, microelectrode implantation surgeries modified some physiological and pathological behaviours; therefore, it is important to consider this fact when it is working with animal models.

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Section: Behavioural Neurologysupporting

confidence: 93%

Changes in Physiological and Pathological Behaviours Produced by Deep Microelectrode Implantation Surgery in Rats: A Temporal Analysis

Chiprés-Tinajero

Núñez-Ochoa

Medina‐Ceja

2020

Behavioural Neurology

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“…The prevalence of anxiety and depressive disorders among PWE has been reported to be between 20 and 50% 23,24,25 . In the literature, depression and anxiety have also been reported to be more common among the spouses of PWE, in relation to the control group 4,13,26 . In the study by Hamamci et al, the BDI and BAI rates were 50 and 66.7% 13 .…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, depression and anxiety have also been reported to be more common among the spouses of PWE, in relation to the control group 4,13,26 . In the study by Hamamci et al, the BDI and BAI rates were 50 and 66.7% 13 . We found that BDI and BAI scores were notably higher than normal among the spouses of PWE, at rates of 68.3 and 77%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Higher levels of depression and anxiety have been found among the caregivers of PWE, in comparison with the control group, in several recent reports 6,7,8 . However, although studies on sleep quality indexes among PWE have already been conducted 9,10,11,12 , research addressing the sleep quality of the caregivers of PWE is extremely rare 13,14 .…”

Section: Introductionmentioning

confidence: 99%

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Depression, anxiety levels and sleep quality indexes among the spouses of people with epilepsy

Önder

Ulusoy

Baydar

et al. 2021

Arq. Neuro-Psiquiatr.

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Background: Psychiatric problems and sleep disturbances are comorbidities that are frequently encountered among people with epilepsy. However, their presence among the spouses of peoples with epilepsy remains to be elucidated. Objective: The objective of this study was to evaluate the spouses of people with epilepsy (PWE), with and without a history of seizures during sleep, in terms of depression, anxiety and sleep quality. Methods: This prospective, cross-sectional study was conducted in three groups of 18 to 65-year-olds. Group 1 consisted of healthy spouses of 127 healthy volunteers without any known neurological disease; group 2 comprised spouses of 63 PWE who had no history of seizure during sleep; and group 3 consisted of spouses of 63 PWE who had a history of at least one seizure during sleep in the course of the previous year. Questionnaires seeking demographic data and the Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory and Beck Anxiety Inventory were applied to all participants. Results: The depression scores of the group of spouses of PWE were higher than those of the control group and were higher in group 3 than in group 2 (p = 0.017). The anxiety scores of the group of spouses of PWE were significantly higher than those of the control group, but no difference in anxiety scores was found between group 2 and group 3 (p = 0.170). The mean PSQI score of group 3 was higher than that of group 2 (p = 0.029). However, regression analyses did not show any difference between these groups. Conclusion: We found that the PSQI scores, which reflected sleep quality, were higher among the spouses of PWE who had seizures during sleep and who had more severe epilepsy.

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“…An individual's sleep quality may be affected by his/her spouse's health condition; uncontrolled and severe sleep disorders may have negative impacts on spouses' health and caring burden. For example, Hamamci et al reported that the Pittsburgh Sleep Quality Index (PSQI) score, which reflects sleep quality, was higher in spouses of people with epilepsy, who had seizures during sleep [1]. Recently, Say et al reported that sleep quality of spouses of patients with restless legs syndrome (RLS), a sensorimotor disorder that mainly occurs during nocturnal sleep period, was significantly worse compared with healthy volunteers, and that deteriorated sleep quality, insomnia and elevated daytime sleepiness of the spouses were correlated with RLS severity of the patients [2].…”

mentioning

confidence: 99%

The bidirectional relationship between patients’ sleep disorders and their spouses’ sleep quality

Inoue

2021

Sleep Biol. Rhythms

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Evaluation of sleep quality in spouses of people with epilepsy

Cited by 10 publications

References 35 publications

Changes in Physiological and Pathological Behaviours Produced by Deep Microelectrode Implantation Surgery in Rats: A Temporal Analysis

Changes in Physiological and Pathological Behaviours Produced by Deep Microelectrode Implantation Surgery in Rats: A Temporal Analysis

Depression, anxiety levels and sleep quality indexes among the spouses of people with epilepsy

The bidirectional relationship between patients’ sleep disorders and their spouses’ sleep quality

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