Evaluation of solid breast lesions with power Doppler sonography

Kook, Shin Ho; Park, Hae Won; Lee, Young‐Rae; Lee, Young-Uk; Pae, Won Kil; Park, Yong-Lai

doi:10.1002/(sici)1097-0096(199906)27:5<231::aid-jcu2>3.0.co;2-p

Cited by 86 publications

(79 citation statements)

References 22 publications

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“…Currently, ultrasonography (US) and mammography are the most frequently used non-invasive methods for detecting breast cancer [1][2][3], while Doppler techniques may be used in parallel to provide additional information [4,5] and obtain better diagnostic accuracy [6,7]. Complementary to these methods, elastography adds supplementary information regarding differences in elasticity and stiffness between different tissues [8][9][10][11].…”

Section: Introductionsupporting

confidence: 57%

Qualitative strain elastography – strain ratio evaluation - an important tool in breast cancer diagnostic

et al. 2016

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Aims: To assess the quality of real time elastography as a differential diagnosis tool for breast nodules and to compare it with standard ultrasonography. Material and methods: In this prospective study we enrolled 174 patients in which 174 dominant breast nodules were considered for the final diagnosis. The results of ultrasonography and real time elastography, both qualitative and quantitative, were compared with pathology findings from the biopsy specimens. Results: Pathology examinations determined 102 nodules were benign and 72 malignant. Qualitative elastography had a better diagnostic performance (82.4% sensitivity and 81.9% specificity) than ultrasonography plus Doppler evaluation (70.3% sensitivity and 73.5% specificity). Quantitative elastography, assessed using the fat-to-lesion ratio, was a good discriminant for malignancy (AUROC = 0.93, p < 0.001). Our results pointed to an optimal threshold for malignancy of > 4.88; by using this threshold, the diagnostic reliability of the fat-to-lesion ratio was better than both ultrasonography and qualitative elastography (86.5% sensitivity and 90.4% specificity). Conclusion: Real time elastography is superior to ultrasonography in diagnosing malignant breast nodules. The evaluation of nodules using a fat-to-lesion ratio was a better discriminant for malignancy than qualitative elastography.

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Section: Introductionsupporting

confidence: 57%

Qualitative strain elastography – strain ratio evaluation - an important tool in breast cancer diagnostic

et al. 2016

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“…For the quantification of tumor vascularization, we used power Doppler sonography as a method developed in vivo in small animals. Power Doppler sonography was used for the first time in human breast tumor studies 20 years ago and has been validated in providing overall assessment of tumor vascularization (30). This noninvasive technique offers many advantages, such as high sensitivity, simplicity of use, and repeatability (31).…”

Section: Discussionmentioning

confidence: 99%

Sensitization by Dietary Docosahexaenoic Acid of Rat Mammary Carcinoma to Anthracycline: A Role for Tumor Vascularization

Colas

Mahéo

Denis

et al. 2006

Clinical Cancer Research

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Purpose: To investigate whether dietary docosahexaenoic acid (DHA), a peroxidizable polyunsaturated N-3 fatty acids, sensitizes rat mammary tumors to anthracyclines and whether its action interferes with tumor vascularization, a critical determinant of tumor growth. Experimental Design: Female Sprague-Dawley rats were initiated by N-methylnitrosourea to develop mammary tumors and then assigned to a control group (n = 18), receiving a supplementation of palm oil, or to a DHA group (n = 54), supplemented with a microalgae-produced oil (DHASCO, 1.5 g/d). The DHA group was equally subdivided into three subgroups with addition of different amounts of a-tocopherol. Epirubicin was injected weekly during 6 weeks after the largest tumor reached 1.5 cm 2 , and subsequent changes in the tumor surface were evaluated. Tumor vascularization was assessed by power Doppler sonography before and during chemotherapy.Results: DHA and a-tocopherol were readily absorbed and incorporated into rat tissues. Epirubicin induced a 45% mammary tumor regression in the DHA-supplemented group, whereas no tumor regression was observed in the control group. In the DHA group, before chemotherapy was initiated, tumor vascular density was 43% lower than in the control group and remained lower during chemotherapy. Enhancement of epirubicin efficacy by DHA was abolished in a dosedependent manner by a-tocopherol, and the same trend was observed for DHA-induced reduction in tumor vascular density. Conclusions: Dietary DHA supplementation led to a reduction in tumor vascularization before the enhancement of any response to anthracyclines, suggesting that DHA chemosensitizes mammary tumors through an inhibition of the host vascular response to the tumor.

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“…(17) Since PDUS measures the amplitude of blood flow, it is angle-independent and avoids aliasing artefacts. (18,19) Although PDUS has shown great potential in predicting malignancy, (16,19,20) its use is limited by the lack of standard interpretation guidelines.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of solid breast lesions with power Doppler: value of penetrating vessels as a predictor of malignancy

Ibrahim¹,

Rahmat²,

Fadzli³

et al. 2016

smedj

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METHODSGreyscale ultrasonography (US) and PDUS were prospectively performed on 91 women in Malaysia with histopathologically proven breast lesions. The diagnostic accuracy of greyscale US, PDUS, and both greyscale US and PDUS was calculated and compared. RESULTSThe 91 women had 102 breast lesions (55 benign, 47 malignant). Of the 47 malignant lesions, 36 demonstrated intratumoural penetrating vessels. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of greyscale US findings in diagnosing malignancy were 100.0%, 71.4%, 74.1% and 100.0%, respectively. The presence of calcification in the breast lesion and the margin, shape and posterior acoustic features of the lesion were significant parameters in predicting malignancy (p < 0.01). The sensitivity, specificity, PPV and NPV of the presence of intratumoural penetrating vessels in predicting malignancy were 76.5%, 80.0%, 76.5% and 80.0%, respectively. When both greyscale US and PDUS were used, there was a significant correlation in predicting malignancy (p < 0.05). The specificity and PPV values of the combined greyscale US and PDUS method (89.0% and 85.7%, respectively) were higher than those of greyscale US or PDUS alone.CONCLUSION Flow patterns revealed by PDUS can be useful for differentiating benign and malignant breast lesions.The visualisation of penetrating vessels in solid breast lesions can be used to complement greyscale US findings in predicting malignancy.

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Evaluation of solid breast lesions with power Doppler sonography

Cited by 86 publications

References 22 publications

Qualitative strain elastography – strain ratio evaluation - an important tool in breast cancer diagnostic

Qualitative strain elastography – strain ratio evaluation - an important tool in breast cancer diagnostic

Sensitization by Dietary Docosahexaenoic Acid of Rat Mammary Carcinoma to Anthracycline: A Role for Tumor Vascularization

Evaluation of solid breast lesions with power Doppler: value of penetrating vessels as a predictor of malignancy

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