Evaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers

Abstract

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Sourcing, thermodynamics, and ring-opening (co)polymerization of substituted δ-lactones: a review

“…28,33,34 While increasing the biobased content in such (co)polyesters, poly(substituted δ-lactone)s were proven to induce a better encapsulation of hydrophobic drugs facilitating their formulation in water. 35,36 In comparison with unsubstituted δ-valerolactone, these lactones possess harsh thermodynamic parameters due to the…”

“…A comparison with a commercially available drug carrier (Soluplus®) showed a 334-fold increment in aqueous solubility of clotrimazole using particles of carboxyl terminated p(δ-JL) copolymer. 36 Nanoemulsion in PBS using Pluronic F-68 as a surfactant and pDL as the oil phase was shown to greatly increase the aqueous solubility of various hydrophobic drugs from 3 to 10 times compared to surfactant micelles alone. 34 Moreover, good stability and a similar toxicity were induced by the use of pDL instead of classical oils.…”

“…28,33,34 While increasing the biobased content in such (co)polyesters, poly(substituted δ-lactone)s were proven to induce a better encapsulation of hydrophobic drugs facilitating their formulation in water. 35,36…”

Functional block copolymer micelles based on poly (jasmine lactone) for improving the loading efficiency of weakly basic drugs

“…Thereaer, we introduced hydroxyl, amine and carboxyl groups via UV mediated thiol-ene click chemistry. 30,31 Due to the presence of free functional groups, we believe that this novel polymer could be a promising alternative to improve the drug loading content within PMs.…”

“…Soluplus® was reported to increase the aqueous solubility of various hydrophobic drugs such as estradiol, carbamazepine and griseofulvin. 31 …”