Evaluation of some new heterocycles bearing 2‐oxoquinolyl moiety as immunomodulator against highly pathogenic avian influenza virus (H₅N₈)

Abstract

The hydrazide obtained from furan‐2(3H)‐one integrated with a quinolin‐2(1H)‐one core reported previously by our research group was utilized as a building block synthon to obtain some pyrrolone, pyridazinone, oxadiazole, and triazole derivatives through treating with some carbon electrophilic reagents, for example, chloroacetyl chloride, benzoyl chloride, acetic anhydride, carbon disulfide, 3,4‐dimethoxybenzaldehyde, and 2‐oxoquinolin‐3‐carbaldehyde to achieve the target heterocycles. The newly synthesized compounds were evaluated as immunomodulator against highly pathogenic avian influenza virus (H5N8). The compounds 1, 11, and 17 displayed the highest potency (100% protection).

Synthesis and antioxidant, antimicrobial, and antiviral activity of some pyrazole-based heterocycles using a 2(3H)-furanone derivative

“…Pyrazoles represent important classes of the heterocyclic systems because of their synthetic and pharmacological properties including antiviral, anticancer, antioxidant, insecticidal, and antimicrobial activities [ 1 – 9 ]. The 2(3 H )-furanones, which are widely recognized as essential components of natural products, were easily converted into a variety of nitrogen heterocycles [ 10 – 14 ]. Also, pyrrolones offered a broad range of pharmacological properties [ 15 ].…”