Evaluation of some Pharmacodynamic Effects ofMentha longifoliaExtracts

Abstract

Huinulus lupulus L. (hop) (Cannabidaceae) has been reported to have hypnotic and sedative effects (1-3). But there have been few recent reports concerning the detailed behavioral effects of the hop. Thus, we have investigated the CNS effects of Humulus lupulus (hop) extract using several behavioral tests, such as spontaneous locomotor activity, rotarod test, potentiation of pentobarbital-induced sleep, hypothermic, analgesic, and anticonvulsant tests in mice. Hop extracts (Emil Flachsmann AG) was administered to ICR mice (30-40 g, 6-8 weeks of age) at the doses of 100, 250, or 500 mg/kg i.p., thirty minutes before each test. 1: Spontaneous locomotor activity: Spontaneous locomotor activity (Rhema-Lahoratechnic, Karl KoIb Co.) measured for 1 h was dose-dependently suppressed at doses above 250 mg/kg i.p.. 2: Rotarod performance: The time which mice were able to remain on the rotarod (13 rev. min1, diameter of 5.5 cm, cutoff time of 2 mm) was decreased by 59% and 65%, at the dose of 250 and 500mg/kg i.p., respectively.

The effect of inhalation ofCitrus sinensisflowers andMentha spicataleave essential oils on lung function and exercise performance: a quasi-experimental uncontrolled before-and-after study

“…Studies have shown that inhalations of various species of peppermint were effective in reducing muscle pain and fatigue as well as they had muscle relaxation effect [ 46 – 48 ].…”

The effects of peppermint on exercise performance

“…Previous studies have shown that various kinds of mint were effective in reducing muscle pain [19,20], muscle relaxation, and reduce fatigue [21]. However, previous studies showed inhaling peppermint aroma has no effect on the lung function tests and physical performance during acute and intensive exercise [18].…”