Due to global warming, population growth, and urbanisation, demands for space cooling in buildings have significantly increased. Mechanical vapour compression cooling technology is relatively mature, well-understood and most commonly used globally. However, they suffer from high energy consumption and adverse environmental impact due to the refrigerants used. As ambient temperature and humidity have significant effects on the performance of vapour compression systems, this paper experimentally and numerically investigates their impact on the performance of vapour compression air conditioning system in terms of power consumption and cooling capacity. It was concluded that at ambient humidity of 55%, as the ambient temperature increases from 22 °C to 40 °C, the compressor temperature has increased from 46 °C to 59 °C which increased its power consumption from 751.2 to 935.52 Watts, giving an increase of 10.24 Watts for every one degree of ambient temperature increase. Also, as ambient humidity in-creased from 32% to 88%, the power consumption increased from 739.2 Watts to 853.2 Watts, an increase of 114 Watts. A validated CFD (Computational Fluid Dynamics) model was developed and predicted a loss in the enthalpy change from 11.7kJ/kg.d.a to 3.6kJ/kg.d.a. due to ambient temperature increasing from 22 °C to 40 °C and a loss of enthalpy change from 12.857kJ/kg.d.a to 5.524kJ/kg.d.a. due to increasing the ambient air humidity from 32% to 88%. This work high-lighted the impacts of ambient conditions on the performance of vapour compression cooling system in terms of increased power consumption and loss of cooling capacity.