Evaluation of spontaneous regional brain activity in weight-recovered anorexia nervosa

Seidel, Maria; Geisler, Daniel; Borchardt, Viola; King, Joseph A.; Bernardoni, Fabio; Jaite, Charlotte; Roessner, Veit; Calhoun, Vince D.; Walter, Martin; Ehrlich, Stefan

doi:10.1038/s41398-020-01081-0

Cited by 16 publications

(24 citation statements)

References 74 publications

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“…We collected two sets of rsfMRI imaging data with opposite polarities of the PE direction (i.e., AP and PA) from healthy participants and investigated whether the outcome of gender differences in spontaneous brain activity was influenced by PE direction. We utilized spontaneous brain activity indices (i.e., ALFF, fALFF, ReHo, DC, and seed-based rsFC), which are the methods performed most frequently by the studies when analyzing rsfMRI data ( Biswal et al, 2010 ; Seidel et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Phase-Encoding Direction on Gender Differences: A Resting-State Functional Magnetic Resonance Imaging Study

Wang

Chen

et al. 2022

Front. Neurosci.

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AimNeuroimaging studies have highlighted gender differences in brain functions, but conclusions are not well established. Few studies paid attention to the influence of phase-encoding (PE) direction in echo-planar imaging on gender differences, which is a commonly used technique in functional magnetic resonance imaging (fMRI). A disadvantage of echo-planar images is the geometrical distortion and signal loss due to large susceptibility effects along the PE direction. The present research aimed to clarify how PE direction can affect the outcome of a specific research on gender differences.MethodsWe collected resting-state fMRI using anterior to posterior (AP) and posterior to anterior (PA) directions from 113 healthy participants. We calculated several commonly used indices for spontaneous brain activity including amplitude of low frequency fluctuations (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC) of posterior cingulate cortex for each session, and performed three group comparisons: (i) AP versus PA; (ii) male versus female; (iii) interaction between gender and PE direction.ResultsThe estimated indices differed substantially between the two PE directions, and the regions that exhibited differences were roughly similar for all the indices. In addition, we found that multiple brain regions showed gender differences in these estimated indices. Further, we observed an interaction effect between gender and PE direction in the bilateral middle frontal gyrus, right precentral gyrus, right postcentral gyrus, right lingual gyrus, and bilateral cerebellum posterior lobe.ConclusionThese apparent findings revealed that PE direction can partially influence gender differences in spontaneous brain activity of resting-state fMRI. Therefore, future studies should document the adopted PE direction and appropriate selection of PE direction will be important in future resting-state fMRI studies.

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Section: Introductionmentioning

confidence: 99%

Effect of Phase-Encoding Direction on Gender Differences: A Resting-State Functional Magnetic Resonance Imaging Study

Wang

Chen

et al. 2022

Front. Neurosci.

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“…We consider that the presently applied threshold (using the typical SPM based approach with Gaussian random field theory, with cluster defined threshold with a voxel height threshold of p < 0.001 and cluster-level threshold of p < 0.05 FWE corrected) is strict enough to control FWE, even when we take into account the problem raised by Eklund et al (70). Many recent neuroimaging studies (110,111) also used a similar threshold for multiple comparison correction. Nevertheless, the possibility of false-positive risk cannot be completely ruled out.…”

Section: Discussionmentioning

confidence: 99%

Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects

et al. 2022

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BackgroundSymptoms of obsessive-compulsive disorder (OCD) have been conceptualized as manifestations of decision-making deficits. Patients with OCD exhibit impairment during the decision-making process, as assessed by the Iowa Gambling Task (IGT). This impairment is independent of clinical severity and disease progression. However, the association between the decision-making deficit and resting-state brain activity of patients with OCD has not been examined.MethodsFifty unmedicated patients with OCD and 55 matched control subjects completed IGT. Resting-state brain activity was examined using the fractional amplitude of low-frequency fluctuations (fALFFs). fALFF analysis focused on the slow-4 and 5 bands. Group comparisons were performed to determine the association between IGT performance and fALFFs.ResultsThere was a significant group difference in the association between the IGT total net score and slow-4 fALFFs in the left putamen (voxel height threshold of p < 0.001; cluster size threshold of p < 0.05; family wise error-corrected). Higher putamen slow-4 fALFFs were correlated with lower IGT scores for OCD patients (r = −0.485; p < 0.0005) and higher IGT scores for control subjects (r = 0.402; p < 0.005). There was no group difference in the association between the IGT total net score and slow-5 fALFFs.ConclusionsThese findings in unmedicated patients demonstrate the importance of resting-state putamen activity for decision-making deficit associated with OCD, as measured by IGT. The inverse correlation may be explained by the hypersensitive response of the putamen in patients with OCD.

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“…The highest incidence rates of AN are in the age range 14-19, with a peak in 14-15 years [5]. Beside, chronic undernutrition and years of illness-related deprivation may have their own consequences on brain structure and function [6]. Thus, it seems particularly important to investigate the disease in adolescence and to identify vulnerability markers to develop prevention and early intervention strategies.…”

Section: Dear Editormentioning

confidence: 99%

The challenge to disentangle age and recovery effects in research focusing on adolescent anorexia nervosa

2022

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Evaluation of spontaneous regional brain activity in weight-recovered anorexia nervosa

Cited by 16 publications

References 74 publications

Effect of Phase-Encoding Direction on Gender Differences: A Resting-State Functional Magnetic Resonance Imaging Study

Effect of Phase-Encoding Direction on Gender Differences: A Resting-State Functional Magnetic Resonance Imaging Study

Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects

The challenge to disentangle age and recovery effects in research focusing on adolescent anorexia nervosa

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