Evaluation of structural connectivity changes in betel-quid chewers using generalized q-sampling MRI

Weng, Jun‐Cheng; Kao, Te-Wei; Huang, Guo-Joe; Tyan, Yeu–Sheng; Tseng, Hsien-Chun; Ho, Ming-Chou

doi:10.1007/s00213-017-4602-0

Cited by 16 publications

(20 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased functional connectivity in the frontotemporal, bilateral frontoparietal, and occipital/parietal networks in BQ chewers were also found in this study. These results are similar to other recent findings ( 16 ) showing increased diffusion anisotropy in the temporal gyrus, the bilateral superior and inferior parietal lobule, and occipital gyrus. The temporal gyrus may be involved in auditory processing ( 47 ), perception of facial emotions ( 48 ), and social cognition ( 49 ).…”

Section: Discussionsupporting

confidence: 93%

“…Decreased functional connectivity was also found in the parietal network in BQ chewers compared to HCs. Weng et al ( 16 ) found increased diffusion anisotropy in the inferior parietal lobule in BQ chewers. However, decreased long-range functional connectivity density in the bilateral inferior parietal lobule was observed in BQ chewers relative to HCs ( 63 ).…”

Section: Discussionmentioning

confidence: 99%

“…With respect to structural brain abnormalities associated with BQ chewing, Chen et al ( 15 ) found that subjects with BQ dependence exhibited significant gray matter volume loss in the midbrain, right rostral anterior cingulate cortex (ACC), bilateral dorsolateral prefrontal cortex, and right superior temporal gyrus, as well as increased gray matter volume in the hippocampal and precuneus. In another structural study of white matter abnormalities in BQ chewers, Weng et al ( 16 ) reported that regions including the right ACC, the midbrain, the bilateral angular gyrus, the right superior temporal gyrus, the bilateral superior occipital gyrus, the left middle occipital gyrus, the bilateral superior and inferior parietal lobule, and the bilateral postcentral and precentral gyrus were increased in BQ chewers compared to controls ( 16 ). In addition, recent functional studies of BQ chewers using functional magnetic resonance imaging (fMRI) ( 17 ) found that connectivity from the ACC to the reward network was increased and connectivity from the ACC to the default mode network (DMN) was decreased in BQ chewers compared to healthy controls (HCs).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Altered Brain Functional Connectivity in Betel Quid-Dependent Chewers

Huang

Liu

et al. 2017

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundBetel quid (BQ) is a common psychoactive substance worldwide with particularly high usage in many Asian countries. This study aimed to explore the effect of BQ use on functional connectivity by comparing global functional brain networks and their subset between BQ chewers and healthy controls (HCs).MethodsResting-state functional magnetic resonance imaging (fMRI) was obtained from 24 betel quid-dependent (BQD) male chewers and 27 healthy male individuals on a 3.0T scanner. We used independent component analysis (ICA) to determine components that represent the brain’s functional networks and their spatial aspects of functional connectivity. Two sample t-tests were used to identify the functional connectivity differences in each network between these two groups.ResultsSeventeen networks were identified by ICA. Nine of them showed connectivity differences between BQD and HCs (two sample t-tests, p < 0.001 uncorrected). We found increased functional connectivity in the orbitofrontal, bilateral frontoparietal, frontotemporal, occipital/parietal, frontotemporal/cerebellum, and temporal/limbic networks, and decreased connectivity in the parietal and medial frontal/anterior cingulate networks in the BQD compared to the HCs. The betel quid dependence scale scores were positively related to the increased functional connectivity in the orbitofrontal (r = 0.39, p = 0.03) while negatively related to the decreased functional connectivity in medial frontal/anterior cingulate networks (r = −0.35, p = 0.02).DiscussionOur findings provide further evidence that BQ chewing may lead to brain functional connectivity changes, which may play a key role in the psychological and physiological effects of BQ.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Altered Brain Functional Connectivity in Betel Quid-Dependent Chewers

Huang

Liu

et al. 2017

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…To date, there is little evidence examining white matter microstructure alternation in BQD individuals. A recent study using generalized q-sampling imaging reported increased diffusion anisotropy in ACC, parietal, temporal, and occipital regions in BQ chewers compared with healthy controls ( 12 ), which indicated that the influence of BQ chewing on the brain white matter. However, relatively small sample size of this study prevented us from drawing solid conclusion on white matter integrity alternation in BQ chewers.…”

Section: Introductionmentioning

confidence: 97%

White Matter Integrity Deficit Associated with Betel Quid Dependence

et al. 2017

View full text Add to dashboard Cite

Betel quid (BQ) is a commonly consumed psychoactive substance, which has been regarded as a human carcinogen. Long-term BQ chewing may cause Diagnostic and Statistical Manual of Mental Disorders-IV dependence symptoms, which can lead to decreased cognitive functions, such as attention and inhibition control. Although betel quid dependence (BQD) individuals have been reported with altered brain structure and function, there is little evidence showing white matter microstructure alternation in BQD individuals. The present study aimed to investigate altered white matter microstructure in BQD individuals using diffusion tensor imaging. Tract-based spatial statistics was used to analyze the data. Compared with healthy controls, BQD individuals exhibited higher mean diffusivity (MD) in anterior thalamic radiation (ATR). Further analysis revealed that the ATR in BQD individuals showed less fractional anisotropy (FA) than that in healthy controls. Correlation analysis showed that both the increase of MD and reduction of FA in BQD individuals were associated with severity of BQ dependence. These results suggested that BQD would disrupt the balance between prefrontal cortex and subcortical areas, causing declined inhibition control.

show abstract

“…Studies also suggested that there were decreased cognitive functions after long-term BQ chewing, such as attention and inhibition control ( 10 ). Recently, neuroimaging studies compared frequent BQ chewers and controls and found that frequent chewers have altered brain structure ( 11 , 12 ) and resting-state functional connectivity ( 13 – 17 ). Specifically, BQ chewers have decreased functional connectivity in the DMN including ventral medial prefrontal cortex (VMPFC), and orbitofrontal cortex (OFC)/anterior cingulate cortex (ACC) ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Gray-Matter Volumes Associated With Betel Quid Dependence

et al. 2017

View full text Add to dashboard Cite

Betel quid (BQ) is one of the most commonly consumed psychoactive substances. It has been suggested to be associated with various health issues, especially oral cancer. Evidence also points to possible decreased cognitive functions after long-term BQ chewing, such as attention and inhibition control. The present study aims to investigate the brain structure basis of BQ chewing in Hunan province of China. Twenty-five BQ chewers and 25 controls were recruited to participate in this study. Voxel-based morphormetry analysis revealed that there were three key regions showing structural differences between BQ chewers and controls, including bilateral dorsolateral prefrontal cortex (DLPFC)/insula, ventral medial prefrontal cortex, and left orbitofrontal cortex. Moreover, the GMV in the DLPFC could potentially predict BQ dependence scores, level of daily BQ chewing, and history of BQ chewing. These results suggested that participants who showed BQ chewing dependence may have deficit in inhibition control and affective decision-making, and the level of deficit was dependent on the level of daily BQ chewing, and history of BQ chewing. Understanding the neurobiology features of BQ chewing would help us develop novel ways to diagnose and prevent BQ dependence.

show abstract

Evaluation of structural connectivity changes in betel-quid chewers using generalized q-sampling MRI

Abstract: Our results provided further evidence indicating that BQ chewing may lead to brain structure and connectivity changes in BQ chewers.

Cited by 16 publications

References 63 publications

Altered Brain Functional Connectivity in Betel Quid-Dependent Chewers

Altered Brain Functional Connectivity in Betel Quid-Dependent Chewers

White Matter Integrity Deficit Associated with Betel Quid Dependence

Altered Gray-Matter Volumes Associated With Betel Quid Dependence

Contact Info

Product

Resources

About