Evaluation of structured lipids with behenic acid in the prevention of obesity

Abstract

Obesity affects all social classes, making it necessary to develop effective products that aid weight loss or help prevent weight gain. The objective of this work was to study the anti-obesity effects of structured lipids (SL) obtained by enzymatic interesterification, based on olive oil, soy oil and fully hydrogenated crambe oil. Twenty-four C57Bl/6 mice were distributed into four experimental groups according to the diet consumed: Control Diet (CD), Structured Lipids Diet (SLD), High-fat Control Diet (HCD), High-fat Structured Lipids Diet (HSLD). The animals that were fed SLs presented a smaller weight gain, despite a larger intake of the diet. The lowest weight gain was reflected in reduced amounts of adipose tissue and lower liver weight. A significant increase in lipids excreted by the animals in the feces was observed, despite there being no sign of toxicity or presence of diarrhea. The animals that consumed the HSLD presented lower total and LDL-cholesterol, increased HDL-cholesterol and increased hepatic arachidonic acid and docosahexaenoic acid levels. In addition, they did not develop hepatic steatosis. The study therefore showed that SLs could play a major role in combating or preventing obesity and other resultant diseases, without producing side effects.

2,4-Thiazolidinedione in Well-Fed Lactating Dairy Goats: I. Effect on Adiposity and Milk Fat Synthesis

“…We observed only a minor effect of 2,4-TZD on fatty acid composition of the milk, including LCFA with potential positive effects on human health. Among saturated fatty acids affected by 2,4-TZD in our study, stearic acid (C18:0) and behenic acid (C22:0) are known to decrease LDL or total cholesterol in humans and mice [37,38]. Among unsaturated LCFA, proportionally more abundant in TZD vs. CTR goats, punicic acid (C18:3c9,t11,c13) can aid in combating metabolic syndrome [39], and n-7 trans-palmitoleate, abundant in dairy products (possibly the major isomers in our trans-palmitoleate), has been associated with a preventive role in diabetes [40].…”

Butyrate Protects Mice Against Methionine–Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels

“…Our study also found that stearic acid was negatively correlated with several pro-inflammatory cytokines, ALT, and the NAS. Moreira et al (2017) suggested that behenic acid results from reduced TG absorption. Although a high concentration of oleic acid is traditionally used to induce steatosis in vitro ( Porteiro et al, 2017 ), dietary supplementation with oleic acid has been shown to exert several protective effects associated with energy homeostasis in different experimental models of NAFLD ( Lee et al, 2011 ), especially a hypocholesterolemic effect ( Ducheix et al, 2017 ).…”

Lipid Metabolism, Carcass Characteristics and Longissimus dorsi Muscle Fatty Acid Composition of Tropical Crossbred Beef Cattle in Response to Desmanthus spp. Forage Backgrounding

“…Since the docosanoic acid concentration was similar between lucerne and desmanthus forages in this present study, increasing the proportion of desmanthus in the diet may have influenced docosanoic acid production through DHA biohydrogenation or stearic acid elongation. Although docosanoic acid is reported to increase serum cholesterol levels [68], its low proportion and absorption in the intestines, low bioavailability [72] and low concentration in the muscle [67] does not pose any detrimental impact on human health.…”