Evaluation of subclinical atherosclerosis in Turkish patients with acne vulgaris receiving systemic isotretinoin

Karapınar, Tekden; Polat, Mualla; Buğdaycı, Güler

doi:10.1111/dth.13307

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…Saklamaz et al reported that CIMT increases after 4 months in acne patients receiving ISO treatment, so they have suggested that long‐term ISO use increased atherosclerosis risk 7 . In another study, it was claimed that ISO triggered the development of subclinical atherosclerosis in men 25 . In the light of all these data and the findings of our study, we can explain the atherosclerosis pathway seen in Figure 1.…”

Section: Discussionsupporting

confidence: 82%

Increases in uric acid and monocyte‐high‐density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin

Metin

Turan

2021

J of Cosmetic Dermatology

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Purpose We aimed to reveal the relationship of serum uric acid (SUA) with monocyte‐high‐density lipoprotein ratio (MHR) and other inflammatory markers in acne patients before and after isotretinoin treatment. In this way, we can try to shed light on the relationship between isotretinoin treatment and atherosclerosis. Methods Two hundred twenty‐four acne patients who administered isotretinoin (0.5‐1 mg/kg/day) were enrolled in the study. In the pretreatment phase and 3 months after treatment, MHR, SUA, mean platelet volume, neutrophil‐lymphocyte ratio (NLR), platelet‐lymphocyte ratio, monocyte‐lymphocyte ratio, serum triglyceride, total cholesterol, high‐density lipoprotein (HDL), and low‐density lipoprotein (LDL) levels of the patients were analyzed. Results Compared to the pretreatment phase, three months after treatment, there was a statistically decrease in neutrophil count and an increase in lymphocyte count (p: 0.002, p: 0.011, respectively). Accordingly, there was a statistically significant decrease in NLR (p: 0.001). It was noteworthy that MHR and SUA levels increased significantly (p: 0.042, p: 0.010, respectively) and there was a positive correlation between SUA level and MHR (r: 0.212, p: 0.012). Serum total cholesterol, LDL, and triglyceride levels increased and HDL levels decreased significantly after treatment (p: 0.001). Conclusion This study contributes to the comprehension of the relationship between isotretinoin treatment and atherosclerosis, which has been frequently reported in the literature. It was thought that the isotretinoin‐induced SUA increase might be related to dyslipidemia. Isotretinoin may initiate the atherosclerotic process in vascular endothelial and smooth muscles, with SUA increase and HDL decrease. An increase in MHR is also an inflammatory marker indicating this process.

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Section: Discussionsupporting

confidence: 82%

Increases in uric acid and monocyte‐high‐density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin

Metin

Turan

2021

J of Cosmetic Dermatology

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“…9 In another study, it was claimed that ISO triggered the development of subclinical atherosclerosis in men. 29 In the light of all these data and the findings of our study, we can explain the atherosclerosis pathway seen in Figure 1. It was thought that the ISO-induced uric acid increase might be related to dyslipidemia.…”

Section: Discussionsupporting

confidence: 63%

The correlation of monocyte to high-density lipoprotein ratio with uric acid and possible atherosclerotic pathway in patients treated with isotretinoin

Metin¹,

Turan

2020

Preprint

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Purpose: We aimed to reveal the relationship of uric acid with MHR and other inflammatory markers acne patients before and after isotretinoin treatment. In this way, we can try to shed light on the relationship between isotretinoin treatment and atherosclerosis. Methods: Two hundred twenty-four acne patients who administered isotretinoin (0.5-1 mg/kg/day) were enrolled in the study. In the pre-treatment phase and 3 months after treatment, MHR, SUA, mean platelet volume, plateletcrit, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, monocyte-lymphocyte ratio, serum triglyceride, total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels of the patients were analyzed. Results: Compared to the pre-treatment phase, three months after treatment, there was a statistically decrease in neutrophil count and an increase in lymphocyte count (p: 0.002, p: 0.011; respectively). Accordingly, there was a statistically significant decrease in NLR (p: 0.001). It was noteworthy that MHR and SUA levels increased significantly (p: 0.042, p: 0.010; respectively) and there was a positive correlation between SUA level and MHR (r: 0.212, p: 0.012). Serum total cholesterol, LDL, and triglyceride levels increased and HDL levels decreased significantly after treatment (p: 0,001). Conclusion: This study contributes to the comprehension of the relationship between isotretinoin treatment and atherosclerosis, which has been frequently reported in the literature. It was thought that the isotretinoin-induced uric acid increase might be related to dyslipidemia. Isotretinoin may initiate the atherosclerotic process in vascular endothelial and smooth muscles, with uric acid increase and HDL decrease. An increase in MHR is also an inflammatory marker indicating this process.

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“…A total of 16 studies qualified for assessment of eligibility. Finally, 1 study [ 17 ] was excluded according to the exclusion criteria, while 15 studies [ 6 , 7 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ] were found eligible for qualitative and quantitative analysis, including 380 acne vulgaris patients under systemic isotretinoin.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Isotretinoin on Insulin Resistance and Serum Adiponectin Levels in Acne Vulgaris Patients: A Systematic Review and Meta-Analysis

Paschalidou,

Katsaras,

Papoulakis

et al. 2024

Clinics and Practice

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Background: Isotretinoin is the drug of choice for severe acne. We sought to examine the potential link between isotretinoin and insulin resistance. Methods: We conducted a systematic review and meta-analysis in accordance with the PRISMA statement. A comprehensive search of the PubMed/MEDLINE, SCOPUS, and Cochrane databases was performed until 12 January 2022 utilizing the PICO (Patient, Intervention, Comparison, Outcome) tool. Fifteen English-language studies focusing on isotretinoin-treated acne patients were included. Serum levels of insulin, glucose, and adiponectin were evaluated before and after treatment, and insulin sensitivity was assessed using the HOMA–IR. A meta-analysis was conducted using RevMan 5.4.1 software, and a quality assessment was undertaken using the ROBINS-I tool. Results: The meta-analysis unveiled a statistically significant rise in the post-treatment levels of adiponectin, an anti-inflammatory agent, which inhibits liver glucose production while enhancing insulin sensitivity (SMD = 0.86; 95% confidence interval (95% CI) = 0.48–1.25, p-value < 0.0001; I2 = 58%). Our subgroup analysis based on study type yielded consistent findings. However, no statistically significant outcomes were observed for insulin, glucose levels, and the HOMA-IR. Conclusions: There is not a clear association between isotretinoin and insulin resistance, but it appears to enhance the serum levels of adiponectin, which participates in glucose metabolism.

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Evaluation of subclinical atherosclerosis in Turkish patients with acne vulgaris receiving systemic isotretinoin

Cited by 6 publications

References 35 publications

Increases in uric acid and monocyte‐high‐density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin

Increases in uric acid and monocyte‐high‐density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin

The correlation of monocyte to high-density lipoprotein ratio with uric acid and possible atherosclerotic pathway in patients treated with isotretinoin

The Effect of Isotretinoin on Insulin Resistance and Serum Adiponectin Levels in Acne Vulgaris Patients: A Systematic Review and Meta-Analysis

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