Evaluation of subclinical ventricular systolic dysfunction assessed using global longitudinal strain in liver cirrhosis: A systematic review, meta-analysis, and meta-regression

Ridjab, D.; Ivan, Ignatius; Budiman, Fanny; Tenggara, Riki

doi:10.1371/journal.pone.0269691

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…In 19 of these studies reporting GLS values, a total of 1017 patients and 609 controls were included. The investigators found lower absolute GLS values in patients with liver cirrhosis than in controls [Mean Difference −1.43% (−2.79%-0.07%), p = 0.04] [46]. However, this analysis reported increased heterogeneity between studies (I 2 = 0.95, p < 0.00001), did not include all relevant studies [36,47], including a study in non-cirrhotic patients and namely those with chronic hepatitis B [48], and incorporated a study that calculated longitudinal strain with cardiac magnetic resonance [49].…”

Section: How Different Are Left Ventricular Strain Values Of Cirrhoti...mentioning

confidence: 99%

The Contemporary Role of Speckle Tracking Echocardiography in Cirrhotic Cardiomyopathy

Dimitroglou,

Aggeli,

Alexopoulou

et al. 2024

Life

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Cirrhotic cardiomyopathy (CCM) is characterized by elevated cardiac output at rest, an inability to further increase contractility under stress, and diastolic dysfunction. The diagnosis of CCM is crucial as it can lead to complications during liver transplantation. However, its recognition poses challenges with conventional echocardiography techniques. Speckle tracking echocardiography (STE), particularly global longitudinal strain (GLS), is a novel index that enhances the diagnostic efficacy of echocardiography for both ischemic and non-ischemic cardiomyopathies. GLS proves more sensitive in identifying early systolic dysfunction and is also influenced by advanced diastolic dysfunction. Consequently, there is an expanding scope for GLS utilization in cirrhotic cases, with newly updated diagnostic criteria for CCM incorporating GLS. Specifically, systolic dysfunction is now defined as either a left ventricular ejection fraction below 50% or an absolute GLS below 18%. However, conflicting data on GLS alterations in liver cirrhosis patients persist, as many individuals with advanced disease and a poor prognosis exhibit a hyperdynamic state with preserved or increased GLS. Consequently, the presence of CCM, according to the updated criteria, does not exhibit a significant association—in the majority of studies—with the severity of liver disease and prognosis. Furthermore, information on other indices measured with STE, such as left atrial and right ventricular strain, is promising but currently limited. This review aims to offer a critical assessment of the existing evidence concerning the application of STE in patients with liver cirrhosis.

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Section: How Different Are Left Ventricular Strain Values Of Cirrhoti...mentioning

confidence: 99%

The Contemporary Role of Speckle Tracking Echocardiography in Cirrhotic Cardiomyopathy

Dimitroglou,

Aggeli,

Alexopoulou

et al. 2024

Life

View full text Add to dashboard Cite

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Pediatric cirrhotic cardiomyopathy: literature review and effect size estimations of selected parameters

Niculae,

Căinap,

Grama

et al. 2024

Eur J Pediatr

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Liver cirrhosis is a significant global health concern, and cirrhotic cardiomyopathy (CCM) is a notable complication affecting both adults and children. While CCM is well-studied in adults, understanding its manifestation and diagnostic criteria in pediatric patients remains a challenge. This review explores the evidence for structural and functional cardiac alterations in children with liver cirrhosis. Structural abnormalities, including increased left ventricular mass index (LVMI) and altered left ventricular wall thickness ratios, are prevalent in pediatric CCM. These abnormalities persist even after liver transplantation, highlighting the systemic impact of liver disease. Evidence suggests that altered systolic and diastolic function, as well as electrocardiographic abnormalities such as prolonged QT intervals, are common in pediatric CCM. Blood biomarkers, including brain natriuretic peptide (BNP) and troponin levels, offer insights into cardiac function in pediatric cirrhotic patients. Elevated BNP levels correlate with adverse outcomes, indicating its potential as a prognostic marker. However, further research is needed to elucidate the diagnostic utility of these biomarkers in pediatric CCM. Conclusion: This review provides estimates of the standardized mean difference among selected cardiac parameters in children with and without cirrhosis. Tailored diagnostic criteria and comprehensive assessment methods will be essential for accurate diagnosis and effective management of pediatric CCM. What is Known:• CCM adds to the burden of care of patients with cirrhosis.• Diagnostic criteria for adults are evolving, but there are no specific criteria for pediatric CCM. What is New:• Cardiac function in children with cirrhosis indicates some parameters not considered in adults are altered.• Effect size estimations for certain parameters provide a guideline for future research into pediatric CCM.

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Association between vitamin D receptor gene polymorphism and essential hypertension: An updated systematic review, meta-analysis, and meta-regression

Dakota,

Adda’i,

Maulana

et al. 2024

PLoS ONE

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The association between Vitamin D Receptor (VDR) gene polymorphisms and essential hypertension (EH) remains controversial. We searched databases (Cochrane Library, EBSCO, EMBASE, LILACS, ProQuest, PubMed, Science Direct, Springer) for studies on VDR gene polymorphisms and EH until May 30, 2024, following PRISMA guidelines. RevMan 5.4.1 provided pooled odds ratio (OR) under Hardy-Weinberg Equilibrium based on allele, additive, dominant, and recessive genetic models. Meta-regression was performed using Comprehensive Meta Analysis V3. Twenty-two studies from thirteen countries were analyzed. The recessive model suggested lower EH risk in individuals with the recessive allele (bb) of BsmI (OR: 0.81; 95%CI, 0.69 to 0.94, p = 0.007; I2 = 35%, p = 0.13). No significant associations were found for FokI, ApaI, and TaqI polymorphisms. Methodological quality significantly influenced EH risk associated with the FokI polymorphism across allele, additive, and dominant models (All p<0.0005). Male proportion influenced EH risk in the additive model for the FokI polymorphism (p = 0.0235), while age impacted risk in the recessive model (p = 0.0327). FokI polymorphism’s influence on EH risk varies by sex, age, and study quality. BsmI polymorphism is independently associated with lower EH risk in recessive homozygotes, with no significant associations found for ApaI and TaqI polymorphisms.

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Evaluation of subclinical ventricular systolic dysfunction assessed using global longitudinal strain in liver cirrhosis: A systematic review, meta-analysis, and meta-regression

Cited by 3 publications

References 47 publications

The Contemporary Role of Speckle Tracking Echocardiography in Cirrhotic Cardiomyopathy

The Contemporary Role of Speckle Tracking Echocardiography in Cirrhotic Cardiomyopathy

Pediatric cirrhotic cardiomyopathy: literature review and effect size estimations of selected parameters

Association between vitamin D receptor gene polymorphism and essential hypertension: An updated systematic review, meta-analysis, and meta-regression

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