This paper investigated the influence of compressive fatigue on the sulfate resistance of slag (0, 20, 50, and 70%) contained concrete under steam curing. After 10,000 cycles loading of 0.5, 0.6, and 0.7 stress level, the concrete was exposed to 5% Na 2 SO 4 for 540 days. The compressive strength, relative dynamic modulus of elasticity (RDME) and SO 4 2− contents were tested after sulfate immersion. Results showed that the standard-cured fatigued concrete had less strength reduction than the steam-cured fatigued concrete during sulfate attack. The steam-cured fatigued concrete containing 20% slag suffered the largest strength reduction, followed by the concrete containing 50, 70, and 0% slag. Compressive fatigue at high stress level (0.7) accelerated the sulfate deterioration of PC standard-cured concrete, while the effect of low stress level (0.5) was minor. The RDME was not a sensitive indicator to access the sulfate resistance of concrete at the beginning of immersion. Compressive fatigue distinctly promoted the sulfate diffusion; the effective SO 4 2− diffusion coefficient was increased when damage occurred in slag concrete. Besides, based on the fatigue damage, an experimental model of the sulfate deterioration of fatigued concrete was proposed. K E Y W O R D S compressive fatigue, slag concrete, steam curing, sulfate resistance