Evaluation of Sun Protection Factor of Cosmetic Formulations by a Simple Visual In Vitro Method Mimicking the In Vivo Method

Paula, Leonardo R. de; Parussulo, André L.A.; Araki, Koji; Toma, Henrique E.

doi:10.1002/jps.22797

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Herein the degradation of BPA in an aqueous solution is evaluated using two different systems: direct photolysis (UV‐A and UV‐C irradiation) and photocatalysis (TiO 2 /UV‐A and TiO 2 /UV‐C systems). Both processes, especially photocatalysis with TiO 2 , have been frequently employed to degrade a number of contaminants in aqueous medium, whereas UV‐A light can be conveniently used to mimic solar radiation . High‐resolution mass spectrometry (HRMS), used alone or coupled with liquid chromatography (LC), is employed to identify the recalcitrant by‐products formed under these oxidative conditions.…”

mentioning

confidence: 99%

Photodegradation of bisphenol A in aqueous medium: Monitoring and identification of by‐products by liquid chromatography coupled to high‐resolution mass spectrometry

Silva

Teodoro

Afonso

et al. 2014

Rapid Comm Mass Spectrometry

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confidence: 99%

Photodegradation of bisphenol A in aqueous medium: Monitoring and identification of by‐products by liquid chromatography coupled to high‐resolution mass spectrometry

Silva

Teodoro

Afonso

et al. 2014

Rapid Comm Mass Spectrometry

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“…A exposição aos raios solares por tempo prolongado e sem proteção adequada resulta em diversos efeitos nocivos à saúde, como sensibilidade a luz, manchas, envelhecimento cutâneo, eritema (vermelhidão na pele), despigmentação cutânea e câncer de pele, sendo este último considerado mundialmente uma das causas mais relevantes de mortalidade. 4,5 O Brasil é considerado um dos países de maior incidência de casos envolvendo câncer de pele. Segundo estimativas apontadas pelo Instituto Nacional do Câncer (INCA), o câncer de pele representa 26% dos tumores malignos identificados e leva a óbito aproximadamente 10% dos pacientes.…”

Section: Introductionunclassified

Síntese E Avaliação Das Atividades Fotoprotetora, Citotóxica E Antiviral Contra O Zika Vírus De Derivados Triazólicos Da Benzofenona

Lima

Teixeira

Silva

et al. 2019

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SYNTHESIS AND EVALUATION OF THE PHOTOPROTECTIVE, CYTOTOXIC AND ANTIVIRAL ACTIVITY OF BENZOPHENONE DERIVATIVES CONTAINING 1,2,3-TRIAZOLIC PORTIONS. The benzophenones are synthetic and natural compounds presenting a variety of activities, including photoprotective, cytotoxic and antiviral. It is herein described the preparation of a series of twenty-seven benzophenone derivatives bearing 1,2,3-triazole functionalities and the evaluation of their photoprotective, cytotoxic and antiviral on Zika Virus (ZIKV) activities. The compounds were prepared in three steps, namely reduction of benzophenone, alkylation of diphenylmethanol and CuAAC reactions. The in vitro evaluation of the photoprotective activity revealed that the most active derivative 4-((benzhydryloxy)methyl)-1-(4-nitrobenzyl)-1H-1,2,3-triazole (4k) displayed UVB sun protection factor equal to 6,9±0,53, which make this compound a possible candidate to be used in formulations for photoprotective applications. In terms of cytotoxicity, the compounds were evaluated against MDA-MB-231 and B16F10 cell lines. It was observed that the compounds were more active against MDA-MB-231 cells and three of them were capable of reducing cell viability by approximately 55% at 100 µmol L-1. In the antiviral screening against ZIKV, compound 4-(3-benzhydryloxy)propyl)-1-(3-methylbenzyl)-1H-1,2,3triazole (5j) was the most effective in mantaining Vero cell viability.

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“…According to the Brazilian Instituto Nacional do Câncer (INCA), for the year 2012 the estimate is 134170 new cases of nonmelanoma skin cancer and 6230 new cases of melanoma (Brasil, 2013a,b). Sunscreen, correctly used, is the most effective means of preventing this disease from developing and studies in this area focus on the safety, effectiveness and improvement of these products (Lahmann, Russell, Green, 2011;Paula et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Inorganic UV filters

Manaia

Kaminski

Corrêa

et al. 2013

Braz. J. Pharm. Sci.

105

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Nowadays, concern over skin cancer has been growing more and more, especially in tropical countries where the incidence of UVA/B radiation is higher. The correct use of sunscreen is the most efficient way to prevent the development of this disease. The ingredients of sunscreen can be organic and/or inorganic sun filters. Inorganic filters present some advantages over organic filters, such as photostability, non-irritability and broad spectrum protection. Nevertheless, inorganic filters have a whitening effect in sunscreen formulations owing to the high refractive index, decreasing their esthetic appeal. Many techniques have been developed to overcome this problem and among them, the use of nanotechnology stands out. The estimated amount of nanomaterial in use must increase from 2000 tons in 2004 to a projected 58000 tons in 2020. In this context, this article aims to analyze critically both the different features of the production of inorganic filters (synthesis routes proposed in recent years) and the permeability, the safety and other characteristics of the new generation of inorganic filters.Uniterms: Skin cancer. Sunscreen. Inorganic UV filter.A preocupação com o câncer de pele hoje em dia vem crescendo cada vez mais principalmente em países tropicais, onde a incidência da radiação UVA/B é maior. O uso correto de protetores solares é a forma mais eficaz de prevenir o aparecimento desta doença. Os ativos utilizados em protetores solares podem ser filtros orgânicos e inorgânicos. Filtros inorgânicos apresentam muitas vantagens em relação aos orgânicos, tais como fotoestabilidade, ausência de irritabilidade e amplo espectro de proteção. Entretanto, em razão de apresentarem alto índice de refração, os ativos inorgânicos conferem aos protetores solares aparência esbranquiçada, diminuindo sua atratividade estética. Muitas alternativas têm sido desenvolvidas no sentido de resolver este problema e dentre elas pode-se destacar o uso da nanotecnologia. Estima-se que o uso de nanomateriais deve crescer das atuais 2000 para 58000 toneladas até 2020. Neste sentido, este trabalho tem como objetivo fazer a análise crítica abordando diferentes aspectos envolvidos tanto na obtenção de protetores solares inorgânicos (rotas de sínteses propostas nos últimos anos) quanto na permeabilidade, na segurança e em outros aspectos relacionados à nova geração de filtros solares inorgânicos. Unitermos: Câncer de pele. Protetores solares. Filtros inorgânicos.

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Evaluation of Sun Protection Factor of Cosmetic Formulations by a Simple Visual In Vitro Method Mimicking the In Vivo Method

Cited by 6 publications

References 22 publications

Photodegradation of bisphenol A in aqueous medium: Monitoring and identification of by‐products by liquid chromatography coupled to high‐resolution mass spectrometry

Photodegradation of bisphenol A in aqueous medium: Monitoring and identification of by‐products by liquid chromatography coupled to high‐resolution mass spectrometry

Síntese E Avaliação Das Atividades Fotoprotetora, Citotóxica E Antiviral Contra O Zika Vírus De Derivados Triazólicos Da Benzofenona

Inorganic UV filters

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