Evaluation of surrogate markers for human immunodeficiency virus infection among blood donors at the blood bank of "Hospital Universitário Regional Norte do Paraná", Londrina, PR, Brazil

Reiche, Edna Maria Vissoci; Vogler, Ingridt Hildegard; Morimoto, Helena Kaminami; Bortoliero, André Luis; Matsuo, Tiemi; Yuahasi, Kátia Kioko; Cancian, Sanderson Júnior; Koguichi, Roberto Setsuo

doi:10.1590/s0036-46652003000100005

Cited by 6 publications

(10 citation statements)

References 12 publications

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“…The importance of this marker is thus confirmed; it serves as a marker for the risk of other viral infections. Its association with HIV infection in this study is in agreement with the findings of Reiche et al (24) ; this possibly occurs owing to the fact that these viral infections share a common means of transmission.…”

Section: Discussionsupporting

confidence: 93%

“…This is in disagreement with the findings of Reiche et al (24) and Herrera et al (25) , whose conclusions were that the syphilis test is of little importance as an indirect marker for identifying and excluding donations by individuals presenting a high risk of HIV infection. There seems, however, to be some controversy on this subject in the literature: in Ethiopia, Rahlenbeck et al (26) found that HIV positive donors presented a higher risk of being syphilis positive.…”

Section: Discussioncontrasting

confidence: 71%

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Logistic model for determining factors associated with HIV infection among blood donor candidates at the Fundação HEMOPE

Queiroz¹,

Sampaio²,

Santos³

et al. 2012

Revista Brasileira De Hematologia E Hemoterapia

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ObjectiveTo determine factors associated with HIV infection in blood donor candidates in Recife, Brazil.MethodsA transversal study was performed of 106,203 blood donor candidates found eligible by the routine clinical screening process in the blood bank in Recife of the Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE) in the period from January 1998 to November 2003. Additional indirect immune and western blot confirmation tests for HIV infection were performed and the candidates were classified as HIV positive or negative. The Chi-squared test and stepwise multiple logistic regression were conducted to examine any association between HIV infection and age, gender, place of residence, schooling, number of donations and serological tests for core hepatitis B antigen virus (anti-HBc), the hepatitis C antivirus (anti-HCV), human T-type antivirus lymph cells (anti-HTLV 1 and 2), serological tests for syphilis (VDRL) and the hepatitis B virus surface antigen (HBsAg).ResultsIn the observed sample, 0.204% of blood donor candidates were found to be HIV positive. Among the studied variables, the age, education level, residency, donation type, and serologic status for anti-HBc and VDRL tests were found to be associated with HIV infection.ConclusionsThe younger, spontaneous donor candidates living in the Recife metropolitan area with a low level of education and positive for anti-HBc and VDRL have an higher risk of HIV infection than the other candidates. Data such as these are useful to understand the dynamics of infection and to guide healthcare policies.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 71%

Logistic model for determining factors associated with HIV infection among blood donor candidates at the Fundação HEMOPE

Queiroz¹,

Sampaio²,

Santos³

et al. 2012

Revista Brasileira De Hematologia E Hemoterapia

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“…The use of surrogate markers for HIV infection among blood donors has been suggested. 9 The authors showed anti-HBc and anti-HCV as useful surrogate markers for HIV infection in blood donors. In addition, they speculated that screening for these surrogate markers may prevent the small number of cases in which HIV is still transmitted by transfusion.…”

Section: Resultsmentioning

confidence: 99%

Donor Blood Procurement and Utilisation at the University of Benin Teaching Hospital, Benin City

Enosolease¹,

Imarengiaye²,

Awodu³

2004

African Journal of Reproductive Health

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Banked blood is a limited resource in Nigeria. We sought to evaluate factors that may further limit the effective utilisation of donor blood in a tertiary hospital in Benin City. The records of the blood transfusion unit of the hospital were studied to identify the methods of blood procurement and utilisation from January 1, 2000 to December 31, 2002. A total of 11,021 units of blood were received in the blood transfusion unit within this period out of which 1491 (13.5%) donor blood samples were found unfit for transfusion and, hence, discarded. Commercial blood donation accounted for 95.3%, compared to 4.7% from replacement and volunteer donors. Commercial blood donation was a major risk factor for likely disposal of donor blood (x 2 = 74.3, p < 0.0001, OR = 21.1, 95% CI = 7.8-56.7). Expired units of blood with low PCV were discarded for lack of infrastructure to fractionate and store them. Over N 0.8million (US$6000.00) is wasted annually on discarded units of donor blood mainly from commercial donors. A policy on blood procurement to include subgroup selection of donors and improved funding of blood banking services may enhance efficient and effective utilisation of donor blood.

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“…The impact of rejecting donated blood is enormous, given that there is such a great shortage of volunteer donors. On the other hand, accurate tests are increasingly necessary to prevent the risk of contracting an infection by receiving a blood unit unduly released [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Serologic and Molecular Profile of Anti-HBc-Positive Blood Bank Donors in an Area of Low Endemicity for HBV

et al. 2007

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Hepatitis B virus (HBV) infection leaves serological markers that indicate prior contact with the virus or an occult infection. The aim of this study was to determine the profile of HBV markers of individuals from a region of low HBV endemicity excluded from blood donation due to the presence of total anti-HBc antibodies but who tested negative for HBV surface antigen (HBsAg). The profile of 244 subjects exclusively anti-total hepatitis B core (anti-total HBc) reactive was determined. Markers such as anti-HBsAg, HBeAg (HBV core antigen) and anti-HBe (antibody to hepatitis Be antigen) were determined, and HB viral DNA (HBV-DNA) was identified by PCR analysis. Overall, 85.7% of the subjects had an anti-HBs (hepatitis B surface antigen antibody) titer higher than 10 IU/L; 154 samples were negative for HBeAg and 66.5% were reactive for anti-HBe. All samples were negative for HBV-DNA (n = 241). We found a significant association between the anti-HBe and anti-HBs titers (P = 0.026). Most individuals from a low endemic area for HBV have shown anti-HBs titers that confer immunity against HBV, even though they were negative for HBV-DNA. In the light of a shortage of donated blood worldwide, we suggest that special measures should be considered that would facilitate the possible use of these rejected blood units in areas of low endemicity for HBV.

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Evaluation of surrogate markers for human immunodeficiency virus infection among blood donors at the blood bank of "Hospital Universitário Regional Norte do Paraná", Londrina, PR, Brazil

Cited by 6 publications

References 12 publications

Logistic model for determining factors associated with HIV infection among blood donor candidates at the Fundação HEMOPE

Logistic model for determining factors associated with HIV infection among blood donor candidates at the Fundação HEMOPE

Donor Blood Procurement and Utilisation at the University of Benin Teaching Hospital, Benin City

Serologic and Molecular Profile of Anti-HBc-Positive Blood Bank Donors in an Area of Low Endemicity for HBV

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