Evaluation of suspected soft tissue lesion in the prostate bed after radical prostatectomy using 3T multiparametric magnetic resonance imaging

Cha, D.I.; Kim, Chan Kyo; Park, Sung Yoon; Park, Jung Jae; Park, Byung Kwan

doi:10.1016/j.mri.2014.12.003

Cited by 41 publications

(34 citation statements)

References 29 publications

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“…In one study, for detecting recurrence in the prostate bed after RP, the area under the curve for a combined T2-weighted and contrast-enhanced approaches were 0.86 and 0.88 for two independent readers [13]. Other groups have also reported a high sensitivity of MRI to identify local recurrence after prostatectomy; the median PSA levels of patients included in those studies are substantially higher than the PSA levels in patients with early PSA rise reported in this manuscript [7; 23; 24]. Our patient population is more comparable to 11 patients with suspected post-RP recurrence and a mean PSA of 0.24±0.13 ng/mL reported by Rischke et al [12], all of whom had a negative prostate MRI as part of their pre-SRT workup.…”

Section: Discussionmentioning

confidence: 69%

Localizing sites of disease in patients with rising serum prostate-specific antigen up to 1 ng/ml following prostatectomy: How much information can conventional imaging provide?

Vargas

Martin-Malburet

Takeda

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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Purpose Accurate identification of the source of a detectable serum PSA in the postprostatectomy setting is a major challenge amongst the urologic community. The aim of this study was to assess positivity rates of imaging examinations performed in patients with early PSA rise after prostatectomy; and to summarize the management strategies adopted in this clinical scenario. Methods IRB-approved retrospective study of 142 post-prostatectomy patients with PSA rise up to 1 ng/mL who underwent evaluation with combination of multiparametric pelvic MRI +/− whole-body or bone MRI, bone scintigraphy (BS), CT chest-abdomen-pelvis (CT-CAP), FDG-PET/ CT and/or NaF-PET/CT at a single tertiary cancer center. Imaging results were summarized per modality and compared to pathology findings. Results Pelvic MRI was positive in 15/142 (11%) patients (14 patients with local recurrence in the surgical bed and 1 patient with pelvic osseous metastases). Ten of these 15 patients underwent additional imaging exams; none revealed positive findings. Of the 127 patients with negative pelvic MRI, 54 (43%) underwent additional imaging exams; only 1/54 had positive findings (false positive T8 lesion on BS and FDG-PET/CT-biopsy negative for cancer). 12/16 patients with positive imaging findings and 75/126 (60%) patients with negative imaging received treatment (radiation, hormones and/or chemotherapy). Conclusion conventional imaging identified sites of disease, almost always in the form of local recurrence, in a minority of patients with early PSA rise post-prostatectomy.

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Section: Discussionmentioning

confidence: 69%

Localizing sites of disease in patients with rising serum prostate-specific antigen up to 1 ng/ml following prostatectomy: How much information can conventional imaging provide?

Vargas

Martin-Malburet

Takeda

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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“…Median follow up time was 26 months for patients with BCR and 12 months for the control group. This study found that both DCE MRI and DW MRI add value to T2W MRI in detecting BCR after RP (38). Using two readers, the sensitivity was higher for T2W+DCE MRI (76-90%) than for T2W+DW MRI (46-49%).…”

Section: Mpmri Of Bcr Following Radical Prostatectomymentioning

confidence: 87%

“…The results were similar when TRUS biopsy was used as the gold standard. Thus, when feasible, the combination of either DW MRI and T2W MRI is comparable to DCE MRI and T2W MRI (23, 31, 37, 38). A study by Cha et al also looked into the value of different mpMRI sequence combinations to detect BCR following RP.…”

Section: Mpmri Of Bcr Following Radical Prostatectomymentioning

confidence: 93%

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Multiparametric Magnetic Resonance Imaging of Recurrent Prostate Cancer

Mertan

Greer

Borofsky

et al. 2016

Topics in Magnetic Resonance Imaging

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There is growing consensus that multi-parametric MRI (mpMRI) is an effective modality in the detection of locally recurrent prostate cancer after prostatectomy and radiation therapy. The emergence of MR guided focal therapies, such as cryoablation, high-intensity focused ultrasound, and laser ablation, have made the use of mpMRI even more important, as the normal anatomy is inevitably altered and the detection of recurrence is made more difficult. The aim of this article is to review the utility of mpMRI in detecting recurrent prostate cancer in patients following radical prostatectomy (RP), radiation therapy (RT), and focal therapy (FT) and to discuss expected post-treatment mpMRI findings, the varied appearance of recurrent tumors, and their mimics.

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“…Cha ve ark. [14] 43 BCR olgusunu kapsayan çalışmasında, iki okuyucu için, T2+Dinamik kontrastlı incelemenin (DCE) sensitivitesi, T2+DWI'dan fazlayken (%76-90 vs %46-49), spesifitesi hafif düşüktür (%83-88 vs %87-90). Cirillo ve ark.…”

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Prostat Kanserinde Tedavi Sonrasi Goruntulume

Çoşkun¹,

Türkbey²

2018

Trd Sem

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Evaluation of suspected soft tissue lesion in the prostate bed after radical prostatectomy using 3T multiparametric magnetic resonance imaging

Cited by 41 publications

References 29 publications

Localizing sites of disease in patients with rising serum prostate-specific antigen up to 1 ng/ml following prostatectomy: How much information can conventional imaging provide?

Localizing sites of disease in patients with rising serum prostate-specific antigen up to 1 ng/ml following prostatectomy: How much information can conventional imaging provide?

Multiparametric Magnetic Resonance Imaging of Recurrent Prostate Cancer

Prostat Kanserinde Tedavi Sonrasi Goruntulume

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