Evaluation of swine protection with foot-and-mouth disease O1/Campos and O/Primorsky/2014 vaccines against the O Mya-98 lineage virus from East Asia

Choi, Jieun; Jo, Hye Jun; Jung, Sung Suk; Choi, Jida; Lee, Seung Heon; Kim, Ha-Hyun; Kim, Yong Joo; Kim, Byounghan; Kim, Jaejo

doi:10.1016/j.vaccine.2021.02.025

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Therefore, porcine efficacy tests sometimes fail to show the relationship between the serological titer and protection status because of immense superinfection by amplifying aerosol virus after inappropriate challenges [ 21 ]. Therefore, several pig challenge methods were carefully considered for this study, although various challenge methods have already been used in pig efficacy tests, including heel bulb intradermal inoculation [ 22 , 32 , 33 , 34 , 35 ], intramuscular inoculation [ 24 ], intra-oropharyngeal inoculation [ 36 ], and contact challenge by introduction with infected donor [ 37 , 38 ]. Although heel bulb intradermal inoculation is considered the major challenge method due to its superior sensitivity in pigs [ 39 ], its application in pigs is labor-intensive and time-consuming [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs

Kim,

Lee,

Kim

et al. 2023

Vaccines

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To analyze the relationship between homologous and heterologous serological titers of immunized pigs and their protection statuses against FMD virus challenges, in the present study, the correlation between the virus neutralization titers at 21 and 28 dpv and the protection statuses at 28 dpv against challenge with FMD virus was analyzed using data sets comprising five different combinations of homologous or heterologous challenge experiments in pigs vaccinated with type O (n = 96), A (n = 69), and Asia 1 (n = 74). As a result, the experiments were divided into three groups (21D-1, 21D-2, and 21D-3) in the 21-dpv model and two groups (28D-1 and 28D-2) in the 28-dpv model. Each response curve of groups 21D-1 and 21D-2 in the 21-dpv model was very similar to each curve of groups 28D-1 and 28D-2 in the 28-dpv model, respectively, even though there was an exceptional extra group (21D-3) in the 21-dpv model. The average titers estimating 0.75 probability of protection ranged from 1.06 to 1.62 log10 in the 21-dpv model and from 1.26 to 1.64 log10 in the 28-dpv model. In summary, we demonstrated that the serological method is useful for predicting the homologous and heterologous protection statuses of vaccinated pigs.

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Section: Discussionmentioning

confidence: 99%

An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs

Kim,

Lee,

Kim

et al. 2023

Vaccines

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“…Since 2011, FMD outbreaks have occurred eight times including the last outbreak, caused by O/ME-SA/Ind-2001e lineage virus in 2023 in Korea, and immediate eradication through mass vaccination and other control measures has been repeated [11]. Because of genetic differences between past and new isolates through phylogenetic analysis, it is strongly assumed that outbreaks were caused by introduction from FMD-endemic neighboring countries around Korea [12]. Therefore, studying the suitability of vaccines is necessary to address the possible threat of the introduction of genetically distinct FMDV strains, such as A/ASIA/G-VII lineage viruses, into Korea in the future.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Swine Protection with Three Commercial Foot-and-Mouth Disease Vaccines against Heterologous Challenge with Type A ASIA/G-VII Lineage Viruses

Kim,

Lee,

Kim

et al. 2024

Vaccines

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Outbreaks caused by foot-and-mouth disease (FMD) A/ASIA/G-VII lineage viruses have often occurred in Middle Eastern and Southeast Asian countries since 2015. Because A/ASIA/G-VII lineage viruses are reported to have distinct antigenic relatedness with available commercial FMD vaccine strains, it is necessary to investigate whether inoculation with vaccines used in Korea could confer cross-protection against A/ASIA/G-VII lineage viruses. In the present study, we conducted two vaccination challenge trials to evaluate the efficacy of three commercial FMD vaccines (O/Manisa + O/3039 + A/Iraq, O/Campos + A/Cruzeiro + A/2001, and O/Primorsky + A/Zabaikalsky) against heterologous challenge with ASIA/G-VII lineage viruses (A/TUR/13/2017 or A/BHU/3/2017 strains) in pigs. In each trial, clinical signs, viremia, and salivary shedding of virus were measured for 7 days after challenge. In summary, the O/Campos + A/Cruzeiro + A/2001 vaccine provided full protection against two A/ASIA/G-VII lineage viruses in vaccinated pigs, where significant protection was observed. Although unprotected animals were observed in groups vaccinated with O/Manisa + O/3039 + A/Iraq or O/Primorsky + A/Zabaikalsky vaccines, the clinical scores and viral RNA levels in the sera and oral swabs of vaccinated animals were significantly lower than those of unvaccinated controls.

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Foot-and-mouth disease virus strains isolated in Vietnam during 2010-2019: genetic characterization and antigenic relatedness to the Euro SA vaccine

Taffarel,

Barrios Benito,

Hung

et al. 2024

Arch Virol

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Evaluation of swine protection with foot-and-mouth disease O1/Campos and O/Primorsky/2014 vaccines against the O Mya-98 lineage virus from East Asia

Cited by 3 publications

References 20 publications

An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs

An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs

Evaluation of Swine Protection with Three Commercial Foot-and-Mouth Disease Vaccines against Heterologous Challenge with Type A ASIA/G-VII Lineage Viruses

Foot-and-mouth disease virus strains isolated in Vietnam during 2010-2019: genetic characterization and antigenic relatedness to the Euro SA vaccine

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