2020
DOI: 10.1371/journal.pone.0224584
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Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom

Abstract: This study investigated the systemic inflammatory response and mechanism of pulmonary lesions induced by Crotalus durissus cascavella venom in murine in the state of Bahia. In order to investigate T helper Th1, Th2 and Th17 lymphocyte profiles, we measured interleukin (IL) -2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor (TNF) and interferon gamma (IFN-γ) levels in the peritoneal fluid and macerated lungs of mice and histopathological alterations at the specific time windows of 1h, 3h, 6h, 12h, 24h and 48h … Show more

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Cited by 15 publications
(12 citation statements)
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“…Following toxin administration or bite, numerous in vivo studies and clinical cases have reported an elevation in proinflammatory cytokines [100] and clinical symptoms of SIRS which include severe outcomes such as cardiac and respiratory failure [101,102]. Similar observations have been noted in in vivo studies and human case reviews involving venom from snakes of the genera Crotalus [98,103],…”
Section: Cytokine Storm By Scorpions Snakes Insects and Spiderssupporting
confidence: 58%
See 1 more Smart Citation
“…Following toxin administration or bite, numerous in vivo studies and clinical cases have reported an elevation in proinflammatory cytokines [100] and clinical symptoms of SIRS which include severe outcomes such as cardiac and respiratory failure [101,102]. Similar observations have been noted in in vivo studies and human case reviews involving venom from snakes of the genera Crotalus [98,103],…”
Section: Cytokine Storm By Scorpions Snakes Insects and Spiderssupporting
confidence: 58%
“…If the inflammatory response outweighs the anti-inflammatory one and persists over time, multi-organ dysfunction may develop [ 96 ], including the aforementioned lung injury. Following envenomation, the histology of an alveolar epithelial cell revealed cellular senescence, polymorphonuclear cell infiltration, and fibrin deposition in the interstitial and alveolar spaces [ 19 , 97 , 98 ]. However, it is unclear whether the observed alveolar damage directly results from the venom components, an indirect effect mediated by inflammation, or both mechanisms [ 99 ] as most evidence comes from clinical observations and the detection of surrogate biomarkers for inflammation.…”
Section: The Inflammationmentioning
confidence: 99%
“…The systemic inflammatory response and the mechanisms of pulmonary injuries by Crotalus durissus cascavella venom have been also investigated in mice by Azavedo et al (2020) [80]. They reported a significant increase of peribronchial inflammatory infiltrates, emphysema, and focal atelectasis indicative of severe pulmonary inflammation 3 h after venom injection followed by a decrease in the activity of inflammatory response, despite an increase in vascular congestion, alveolar septal thickening, and emphysematous areas at 6 h. Between 12 and 48 h, there were perceptible inflammatory infiltrates in the pulmonary parenchyma, hemorrhagic focuses, vascular congestion, and bronchial muscle distention [80].…”
Section: Discussionmentioning
confidence: 99%
“…The effects of toxins isolated from the venom of bees and snakes have on the progression and development of symptoms in inflammatory and autoimmune disorders such as rheumatoid arthritis (RA) [ 79 ], acute intestinal inflammation [ 80 ], systemic lupus erythematosus (SLE) [ 81 ] and systemic inflammatory syndrome [ 82 ] have been evaluated. Thus, many modulatory effects have been studied, including the modulatory effects of cytokines.…”
Section: Effects On Innate Immunitymentioning
confidence: 99%