Evaluation of Systemic Markers Related to Anemia in Aggressive Periodontitis Patients before and after Phase I Periodontal Therapy: An Interventional Study

Panneerselvam, Shobana; Ramakrishnan, T; Sekhar, Vidya; Mani, Ebenezer; Krishnamurthi, Indhu; Saketharaman, Parthiban

doi:10.5005/jp-journals-10024-3197

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Moreover, periodontopathogens such as Porphyromonas gingivalis ( P. gingivalis ) is associated with cardiovascular disease [ 17 , 18 , 19 ], cancer [ 20 , 21 , 22 ], insulin resistance [ 23 , 24 ], Alzheimer’s disease [ 25 , 26 ], and adverse pregnancy outcomes [ 27 , 28 ]. Furthermore, clinical periodontal treatment is able to improve the anemic status [ 29 ], modulates endotoxemia and stool microbial dysbiosis [ 30 ], could reduce the risks of perinatal mortality and preterm birth [ 31 ], and is beneficial for the effective management of type 2 diabetes [ 32 , 33 , 34 ].…”

Section: Periodontitis: Importance Pathogenesis and Treatmentmentioning

confidence: 99%

Beneficial Effects of Melatonin on Periodontitis Management: Far More Than Oral Cavity

Wang

et al. 2022

IJMS

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Periodontitis as a highly prevalent chronic infection/inflammatory disease can eventually lead to tooth loss and masticatory dysfunction. It also has a negative impact on general health and largely impairs quality of life. The tissue destruction during periodontitis is mainly caused by the excessive immune–inflammatory response; hence, how to modulate the host’s reaction is of profound importance for effective periodontal treatment and tissue protection. Melatonin, as an endogenous hormone exhibiting multiple biological functions such as circadian rhythm regulation, antioxidant, and anti-inflammation, has been widely used in general healthcare. Notably, the past few years have witnessed increasing evidence for the application of melatonin as an adjunctive approach in the treatment of periodontitis and periodontitis-related systemic comorbidities. The detailed underlying mechanisms and more verification from clinical practice are still lacking, however, and further investigations are highly required. Importantly, it is essential to establish standard guidelines in the near future for the clinical administration of melatonin for periodontal health and general wellbeing.

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Section: Periodontitis: Importance Pathogenesis and Treatmentmentioning

confidence: 99%

Beneficial Effects of Melatonin on Periodontitis Management: Far More Than Oral Cavity

Wang

et al. 2022

IJMS

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“…Mechanistically, these cytokines could suppress erythropoiesis, shorten RBC survival, and blunt erythropoietin response. [ 2 11 ] Anemia of chronic disease is the most prevalent anemia after iron deficiency anemia and is a result of the body’s response to an inflammatory disease. [ 12 ] A population-based study on the quality of life of the elderly also supports the association between pro-inflammatory cytokines and C-reactive protein, and unexplained anemia.…”

Section: Introductionmentioning

confidence: 99%

Are adults over 18 years of age with anaemia more likely to develop chronic periodontitis than adults without anaemia? - A systematic review and meta-analysis

Roberts,

Jimson,

Srinivasan

2023

JISPCD

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Aims and Objectives: Periodontitis is a chronic disease affecting the supporting tissues of the teeth and exhibits bidirectional relation with systemic diseases. This study aims to determine the association between chronic periodontitis and erythrocyte functional measures: total red blood cells (RBCs), hemoglobin (Hb) concentration, mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC) by systematic review and meta-analysis. Materials and Methods: A systematic search of the electronic databases PUBMED, OVID, Embase, Web on Science, and Google Scholar was undertaken from inception to July 2022. English language studies that evaluated the erythrocyte functional measures in periodontitis and health were selected. Other review reports, letters/opinion articles, studies without a definition of periodontitis, and the concomitant presence of systemic conditions (diabetes, kidney disease, cancer) were excluded. Two reviewers determined full-text eligibility in a blinded process. Meta-Essentials software was used to generate forest plots and to determine heterogeneity and publication bias. Results: Twenty-six studies involving 1082 patients with chronic periodontitis and 980 healthy controls were analyzed. Pooled results showed lower Hb concentration (Hedges’ g = −1.16; 95% confidence intervals [CI], −1.7 to −0.62), RBC counts (Hedges’ g = −0.85; 95% CI, −1.31 to −0.38) and packed cell volume (−0.56; 95% CI, −1.02 to −0.11) in patients with chronic periodontitis. Conclusion: This meta-analysis showed a decreasing trend in the hematological parameters, including hemoglobin concentration, number of erythrocytes, and hematocrit in patients with chronic periodontitis compared to healthy controls.

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“…[ 18 19 ] The most prevalent kinds of periodontitis are chronic and aggressive, but there are other more complex classifications, including early-onset periodontitis, periodontitis in adulthood, necrotizing ulcerative periodontitis, refractory periodontitis, and periodontitis associated with underlying illnesses (AAP, 1989). [ 20 21 22 ] Hematological indicators, such as hemoglobin (Hb), bleeding time (BT), clotting time (CT), and random blood glucose, are the main focus of the current study.…”

Section: Introductionmentioning

confidence: 99%

Comparison of hematological parameters among chronic periodontitis patients and healthy individuals

Timothy

Rajasekar

2022

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Some of the most common oral disorders are periodontal disease. Variation in hematological parameters in chronic periodontitis patients could affect the type of treatment and its overall outcomes. Comparing and evaluating the hematological parameters in people with chronic periodontitis and the general population was the aim of this study. 100 individuals with chronic periodontitis (Group I) and 100 individuals in clinically good health participated in the study (Group II). Hemoglobin (Hb), random blood sugar (RBS), bleeding time (BT), and clotting time (CT) were evaluated and compared between the two groups. In contrast to patients with chronic periodontitis (8.934 ± 2.0), in healthy patients, the mean Hb concentrations were found to be higher (13.435 ± 1.8). In comparison to healthy individuals (98.98 ± 25.42), patients with chronic periodontitis had a higher mean value for RBS (112.14 ± 47.5). In contrast to the healthy population (BT = 2.654 ± 13.36, CT = 6.057 ± 0.267), patients with chronic periodontitis had shorter mean BT and CT (BT = 0.301 ± 0.07, CT = 2.84 ± 0.6058). Hematological factors and the population's periodontal health were discovered to be significantly associated (P = 0.001). Within the constraints of the continuing investigation, it was shown that among people with chronic periodontitis, Hb levels, BT, and CT were reduced, while blood glucose levels were increased.

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Evaluation of Systemic Markers Related to Anemia in Aggressive Periodontitis Patients before and after Phase I Periodontal Therapy: An Interventional Study

Cited by 3 publications

References 15 publications

Beneficial Effects of Melatonin on Periodontitis Management: Far More Than Oral Cavity

Beneficial Effects of Melatonin on Periodontitis Management: Far More Than Oral Cavity

Are adults over 18 years of age with anaemia more likely to develop chronic periodontitis than adults without anaemia? - A systematic review and meta-analysis

Comparison of hematological parameters among chronic periodontitis patients and healthy individuals

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