Evaluation of T helper17 as skeletal homeostasis factor in peripheral blood mononuclear cells and T helper cells of end-stage renal disease cases with impaired parathyroid hormone

Motavalli, Roza; Soltani-Zangbar, Mohammad Sadegh; Fereydoonzadeh, Khadijeh; Hajivalili, Mahsa; Heris, Javad Ahmadian; Kahroba, Houman; Niknafs, Bahram; Khiavi, Farhad Motavalli; Sadeghi, Mohammadreza; Yousefi, Mehdi; Etemadi, Jalal

doi:10.1007/s11033-023-08306-7

Cited by 1 publication

(1 citation statement)

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“…A possible explanation of high PTH levels can be a relation-ship with vitamin D metabolism, which has been found to be reduced in psoriasis in order to maintain adequate serum calcium levels. In addition to this well-known mechanism, a different implication of high PTH levels in psoriatic patients can be speculated through results provided by Motavalli et al [67]. They showed that high PTH levels correlate with an increased number of Th17 cells in peripheral blood.…”

Section: Discussionmentioning

confidence: 98%

Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis

Formisano,

Proietti,

Borgarelli

et al. 2023

Nutrients

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Psoriasis is a chronic immune-dysregulated inflammatory disease and hypovitaminosis D is considered a risk factor. We conducted an online database search to review and meta-analyze the relationship between vitamin D, other bone metabolism parameters, and psoriasis. The efficacy of oral vitamin D supplementation in improving Psoriasis Area and Severity Index (PASI) was also evaluated. Non-original articles, case reports, and animal studies were excluded. Bias risk was assessed according to the Cochrane Collaboration’s tool and the Newcastle–Ottawa scale in randomized controlled trials (RCTs) and case–control studies, respectively. Unstandardized mean differences were used for data synthesis. Twenty-three studies reported serum 25 hydroxyvitamin D (25(OH)D) levels in 1876 psoriasis patients and 7532 controls. Psoriasis patients had significantly lower 25(OH)D levels than controls (21.0 ± 8.3 vs. 27.3 ± 9.8, p < 0.00001). Conversely, 450 psoriasis patients had lower levels of parathormone than 417 controls (38.7 ± 12.8 vs. 43.7 ± 16.5, p = 0.015). Four RCTs examined the effect of oral vitamin D supplementation on psoriasis for 173 patients and 160 patients were treated with placebo. No significant differences were found in PASI after 3, 6, and 12 months of supplementation. It is shown that 25(OH)D serum levels are significantly lower in psoriasis, but, although the granularity of RCT methodology may have influenced the pooled analysis, vitamin D supplementation did not seem to improve clinical manifestations.

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Section: Discussionmentioning

confidence: 98%