Evaluation of T-wave morphology parameters in drug-induced repolarization abnormalities

Abstract

This study evaluates the predictive values of Twave morphology parameters reflecting the repolarization changes by beat to beat calculation of parameters using different mathematical tools to identify additional markers sensitive to the variation induced by drug in the surface of the electrocardiogram. T-wave morphology indicators are extracted from nearly 6 hours recordings of two patients from a clinical d-Sotalol study. The results show that drug induced change in Twave morphology as well as QT interval. In particular, parameters extracted from spherical coordinates of vectrocardiogram that were not tested before for drug effect evaluation show high sensitivity to small change induced by drugs.