Evaluation of Texture Analysis Parameter for Response Prediction in Patients with Hepatocellular Carcinoma Undergoing Drug-eluting Bead Transarterial Chemoembolization (DEB-TACE) Using Biphasic Contrast-enhanced CT Image Data

Kloth, Christopher; Thaiss, Wolfgang M.; Kärgel, Rainer; Grimmer, Rainer; Fritz, Jan; Ioanoviciu, S. D.; Ketelsen, Dominik; Nikolaou, Konstantin; Horger, Marius

doi:10.1016/j.acra.2017.05.006

Cited by 38 publications

(27 citation statements)

References 21 publications

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“…Nonetheless, it was found that the uniformity of skewness in the arterial phase, as well as the uniformity of heterogeneity in the portal-venous phase, proved to be good predictors. 1 Moreover, we also found that there were no significant differences between any of the CT features regarding P53(À) and P53(þ) groups. This may be due to the number of samples and the average size of the lesions being relatively small.…”

Section: Discussionmentioning

confidence: 51%

“…Textural features have been shown to be beneficial when differentiating tumor types, predicting treatment response, and are also associated with prediction of microvascular invasion and prognosis. 1,3,[20][21][22][23][24][25][26][27] However, it is largely unknown what the biological correlates of textural features are. 20,21 To the best of our knowledge, there has been no study published regarding P53 mutation status and texture features of CT images for HCC.…”

Section: Introductionmentioning

confidence: 99%

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Correlations between P53 Mutation Status and Texture Features of CT Images for Hepatocellular Carcinoma

Chen

et al. 2019

Methods Inf Med

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Objectives To investigate the performance of texture analysis in characterizing P53 mutations of hepatocellular carcinomas (HCCs) based on computed tomography (CT). Methods A total of 63 HCC patients underwent CT scans and were tested for P53 mutations. Patients were divided into two groups of P53(−) and P53(+) according to the P53 scores. First- and second-order texture features were computed from the CT images and compared between groups using independent Student's t-test. A Spearman's correlation coefficient was used for correlations to assess the relationship between the different P53 sores and CT data. The performance of texture features in differentiating the P53 mutations of HCC was assessed using receiver operating characteristic analysis. Results The mean values of angular second moment (ASM; mean = 0.001) and contrast (mean = 194.727) for P53(−) were higher than those of P53(+). Meanwhile the mean values of correlation (mean = 0.735), sum variance (mean = 1,111.052), inverse difference moment (IDM; mean = 0.090), and entropy (mean = 3.016) for P53(−) were lower than those of P53(+). Significant correlations were found between P53 scores and ASM (r = − 0.439), contrast (r = − 0.263), correlation (r = 0.551), sum of squares (r = 0.282), sum variance (r = 0.417), IDM (r = 0.308), and entropy (r = 0.569). Five texture parameters (ASM, contrast, correlation, IDM, and entropy) were predictive of P53 mutation status, with areas under the curve ranging from 0.621 to 0.792. Conclusions There was a direct relationship between P53 mutations and gray-level co-occurrence matrix, but not with histograms for HCC patients. Correlation and entropy seemed to be the most promising in differentiating P53 (−) from P53(+).

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Correlations between P53 Mutation Status and Texture Features of CT Images for Hepatocellular Carcinoma

Chen

et al. 2019

Methods Inf Med

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“…Kloth et al compared the performance of CT texture analysis (CTTA) with perfusion CT for predicting response in patients undergoing DEB-TACE. 63 They found a significant correlation between CTTA and perfusion CT parameters. CTTA parameters were found to predict mid-term response following TACE.…”

Section: Radiomicsmentioning

confidence: 94%

Response Assessment Following Image-Guided Therapy of Hepatocellular Carcinoma

Gupta

Kalra

Gulati

et al. 2020

Journal of Clinical Interventional Radiology ISVIR

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AbstractImage-guided locoregional therapies have an important role in the management of patients with hepatocellular carcinoma (HCC). Recent advances in the ablative as well as endovascular therapies have expanded the role of interventional radiologists in the treatment of HCC. Following image-guided therapy, an accurate response assessment is vital. Knowledge regarding normal postprocedure changes and subtle signs of residual or recurrent disease is important. In this review, we discuss various response evaluation criteria currently employed for HCC. We also discuss the postprocedure imaging features suggestive of residual disease or recurrence and imaging biomarkers for response assessment.

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“…Thus, repeated procedures are needed to achieve better results, although not much survival benefit has been gained with TACE alone [ 13 – 14 ]. Moreover, three-dimensional conformal radiotherapy (3DCRT) [ 15 ], radiofrequency ablation (RFA) [ 16 – 17 ], percutaneous ethanol injection (PEI) [ 18 ], percutaneous acetic acid injection (PAI) [ 19 ], percutaneous microwave coagulation therapy (PMCT) [ 20 ], drug-eluting bead transarterial chemoembolization (DEB-TACE) [ 21 ], and sorafenib [ 22 ] have also been shown to be highly effective in the treatment of HCC. Studies have also suggested that TACE combined with other percutaneous techniques and targeted therapy drugs may improve survival [ 23 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

What is the best combination treatment with transarterial chemoembolization of unresectable hepatocellular carcinoma? a systematic review and network meta-analysis

Xie

Tian

et al. 2017

Oncotarget

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ObjectiveTo assess the comparative efficacy and safety of combination treatment with transarterial chemoembolization (TACE) for patients with unresectable hepatocellular carcinoma (HCC) through a systematic review and network meta-analysis and to identify what is the best combination treatment with TACE.Materials and MethodsA network meta-analysis was used to identify evidence from relevant randomized controlled trials. We searched databases for publications up to June 2017. The prespecified primary efficacy outcomes were treatment response and 6-month to 3-year overall survival (OS), while the secondary efficacy outcomes were 1- and 2-year disease-free survival (DFS); safety outcomes were advance effects of combination treatment. We conducted pairwise meta-analyses using a random-effects model and then performed random-effects network meta-analyses.ResultsA total of 48 trials were eligible (50 analyses), involving 5627 patients and 19 treatment arms. In comparison with other types of combination therapy arms, network meta-analysis disclosed that TACE + three-dimensional conformal radiotherapy, TACE + percutaneous ethanol injection, TACE + percutaneous microwave coagulation therapy, TACE + percutaneous acetic acid injection, and TACE + sorafenib were the more effective methods in treatment response, 6-month to 3-year OS, and 1–2 year DFS; the adverse effects of TACE + sorafenib were serious. The study was registered with PROSPERO, number CRD42017071102.ConclusionsWhen considering the efficacy, combination therapy with TACE seemed to offer clear advantages for patients with unresectable HCC. TACE + Three-dimensional conformal radiotherapy, TACE + Percutaneous ethanol injection, TACE + Percutaneous microwave coagulation therapy, and TACE + Percutaneous acetic acid injection are likely the best options to consider in the application of combination treatment.

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Evaluation of Texture Analysis Parameter for Response Prediction in Patients with Hepatocellular Carcinoma Undergoing Drug-eluting Bead Transarterial Chemoembolization (DEB-TACE) Using Biphasic Contrast-enhanced CT Image Data

Cited by 38 publications

References 21 publications

Correlations between P53 Mutation Status and Texture Features of CT Images for Hepatocellular Carcinoma

Correlations between P53 Mutation Status and Texture Features of CT Images for Hepatocellular Carcinoma

Response Assessment Following Image-Guided Therapy of Hepatocellular Carcinoma

What is the best combination treatment with transarterial chemoembolization of unresectable hepatocellular carcinoma? a systematic review and network meta-analysis

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