Evaluation of the 2-mm punch biopsy in dermatological diagnosis

Todd, P.; Garioch, JJ; Humphreys, S.; Seywright, Morag; Thomson, João Carlos; Vivier, Anthony du

doi:10.1016/s0002-9394(14)70525-2

Cited by 9 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: -5mentioning

confidence: 99%

“…The level of agreement between punch biopsy, conventional incisional biopsy, and histopathologic analysis of the surgical specimen is high. [7][8][9] Punch biopsy can be useful in preoperative assessments of skin disorders. 7 However, the few published studies on punch biopsy in the periocular region-rarely cited by ophthalmologists-lack a complete evaluation of efficacy, especially with regard to histologic type.…”

mentioning

confidence: 99%

“…[7][8][9] Punch biopsy can be useful in preoperative assessments of skin disorders. 7 However, the few published studies on punch biopsy in the periocular region-rarely cited by ophthalmologists-lack a complete evaluation of efficacy, especially with regard to histologic type. 8,9 …”

mentioning

confidence: 99%

See 2 more Smart Citations

Is 2-mm Punch Biopsy Useful in the Diagnosis of Malignant Eyelid Tumors?

Carneiro¹,

Macedo²,

Lima³

et al. 2012

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

Purpose: Two-millimeter punch biopsy is a swift and practical diagnostic tool in the outpatient setting. However, few studies have evaluated the efficacy of the method for diagnosis of malignant eyelid tumors.Methods: This was an observational study of patients with suspicion of malignant eyelid tumor attending the Ocular Plastic Surgery Center at Hospital das Clínicas, University of São Paulo School of Medicine. Following standard procedures, preoperative biopsies were taken with a 2-mm trephine and surgical excision was performed with safety margins, followed by reconstruction. Anatomopathologic analysis of the surgical specimen was used as gold standard to evaluate the accuracy of diagnosis by punch biopsy.Results: The study included 50 periocular tumors with suspicion of malignancy. The indicators of efficacy in the identification of malignancy by 2-mm punch biopsy were: sensitivity 88%, specificity 100%, positive predictive value 100%, and negative predictive value 64%. Accuracy was 90% for malignancy and 80% for histologic type. The κ index of agreement between the diagnostic methods was 0.722 (p < 0.001).Conclusion: A positive result with 2-mm punch biopsy is a safe indication for surgical excision of the tumor, whereas a negative result does not necessarily imply benignity. In cases of high clinical suspicion, a second biopsy should be taken from a different part of the tumor to rule out malignancy. (Ophthal Plast Reconstr Surg 2012;28:282-285) A pproximately 5% to 10% of all skin neoplasms affect the eyelid. In fact, periocular malignancy is the most common type of neoplasm observed at our service.1 Due to their small size, periocular tumors can be hard to diagnose and surgery is often postponed when clinical findings are ambiguous. Despite considerable accuracy in the diagnosis of malignancy, clinical evaluation of patients with periocular tumors frequently yield false-positive and false-negative results, and on the average clinical and histologic findings are poorly correlated. 2-5Several factors have been associated with recurrence of periocular tumors after treatment, such as size, location, and medical conditions related to histologic type.6 Aggressive tumors require larger surgical margins and pose a greater risk of metastasis.Punch biopsy is a swift and simple diagnostic technique requiring very little equipment or surgical skill. A 2-mm trephine will collect a tissue sample large enough for analysis and no suture is necessary. The level of agreement between punch biopsy, conventional incisional biopsy, and histopathologic analysis of the surgical specimen is high. [7][8][9] Punch biopsy can be useful in preoperative assessments of skin disorders.7 However, the few published studies on punch biopsy in the periocular region-rarely cited by ophthalmologists-lack a complete evaluation of efficacy, especially with regard to histologic type. OBJECTIVEThe aim of this study was to evaluate the ability of 2-mm punch biopsy to diagnose malignancy and define the histologic type of eyelid tumors. MATERI...

show abstract

Section: -5mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Is 2-mm Punch Biopsy Useful in the Diagnosis of Malignant Eyelid Tumors?

Carneiro¹,

Macedo²,

Lima³

et al. 2012

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

show abstract

“…However, the medical doctor should have in mind that in some situations, small skin biopsies might cause difficult to the pathologist to establish a diagnose [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…[11] The wound care is usually restricted to daily cleaning, antisepsis, bandage replacement and sometimes antibiotic ointment [8,9,12].…”

Section: Introductionmentioning

confidence: 99%

Collagenase cream in non-stitched skin wounds after punch biopsy

et al. 2015

View full text Add to dashboard Cite

Background: The use of debriding drugs is not common in a situation of acute wound healing, despite its widespread use in chronic wound healing, with satisfactory results. Collagenase is one of the most used debriding drugs, and its application after a non-stitched skin wound biopsy could lead to a better wound healing outcome and less complication. Methods and Findings:Fifteen Wistar rats were used in this study; four excisional wounds were performed on the dorsum of each animal. Once in a day, collagenase cream was applied in the cranial wounds, while the caudal wounds were washed with isotonic saline. After 7, 14 and 21 postoperative days, 5 animals were randomly chosen for macroscopic and microscopic wound analysis.At the 7 th postoperative day: collagenase cream induced greater monocytes invasion, fibroblast invasion, collagen deposit, angiogenesis and reepithelialization. 14 th postoperative day: collagenase cream induced greater neutrophils invasion, fibroblasts invasion, collagen deposit, reepithelialization and higher proportion of type I collagen fibers. 21 st postoperative day: collagenase cream led to greater angiogenesis and reepithelialization. Conclusion:Collagenase cream led to a better wound healing outcome than simply saline rinse, induced earlier angiogenesis and inflammatory step; greater collagen deposit and reepithelialization.

show abstract

Biópsia incisional com trépano de 2 mm em tumores palpebrais

Carneiro¹

View full text Add to dashboard Cite

Evaluation of the 2-mm punch biopsy in dermatological diagnosis

Cited by 9 publications

References 0 publications

Is 2-mm Punch Biopsy Useful in the Diagnosis of Malignant Eyelid Tumors?

Is 2-mm Punch Biopsy Useful in the Diagnosis of Malignant Eyelid Tumors?

Collagenase cream in non-stitched skin wounds after punch biopsy

Biópsia incisional com trépano de 2 mm em tumores palpebrais

Contact Info

Product

Resources

About